PERBEDAAN EFEKTIVITAS ANESTETIKUM ANTARA ZOLETILACEPROMACIN DAN KETAMIN- ACEPROMACIN PADA TIKUS PUTIH (Rattus norvegicus)

  • Retina Yunani(1)
    Laboratorium Farmasi Fakultas Kedokteran Hewan UWKS
  • Era Hari Mudji(2*)
    Laboratorium Klinik Veteriner Fakultas Kedokteran Hewan UWKS
  • Desty Apritya(3)
    Laboratorium Klinik Veteriner Fakultas Kedokteran Hewan UWKS
    • (*) Corresponding Author
DOI: https://doi.org/10.35508/jkv.v3i2.1036
Keywords: ketamin, zoletil, acepromacin, Rattus norvegicus

Abstract

The aim of this research was to find out the effects of zoletil–acepromacin and ketamin–acepromacin as general anaesthetics on heartbeat, respiratory rate, body
temperature, onset of action and duration of action in rat. This research used much as 27 rats and were divided into 3 group of treatments. P0 as a control group was injected with aquabidest by intraperitoneal injection. P1 was injected with atropine sulphate (0,05mg.kg BW) SC for premedication and ketamin (75mg/kgBW) - acepromacin (2,5 mg/kg BW) by IP as anaesthetic. P2 was injected with atropine sulphate (0,05mg/kg BW) SC for premedication and zoletil (50mg/kgBW) - acepromacin (2,5 mg/kg BW) by intraperitoneal as anesthetic. The results showed that the combination of Ketamin-Acepromacin and Zoletil-Acepromacin depress the heart beat and respiratory rate. The body temperature in P2 were recorded lower than in P1. However, the onset of action and duration were longer in P1 than in P2.

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References

Booth NH, D.M. J.I. Mayer, dan L.E.McDonald. (1977). VeterinaryPharmacology. USA The Iowa State University Press. 295- 297.

Flecknell P. 2000. Manual of Rabbit Medicine and Surgery. England. British Small Animal Veterinary Association.

Guyton AC, Hall JE. 1997. Buku Ajar Fisiologi Kedokteran edisi 9. Indonesia. EGC.

Hall LW, Clarke KW. 1983. Veterinary Anaesthesia 9th. Ed. London. Bailliere Tindall. Pp. 58, 60, 308.

Jones LM, Booth NH, McDonald LE. 1997. Veterinary Pharmacology and Therapeutics. New Delhi. Oxford and IBH Pub. Co. Pp292-365.

Kaban IKB. 2013. Pengaruh Acepromacin Sebagai Preanastesi dan Sebagai Campuran Anestetika Ketamin Terhadap Onset Dan Durasi Anestesi Pada Kucing. Yogyakarta.Skripsi Fakultas Kedokteran Hewan Universitas Gajah Mada.

Mullen JM, Lehman J, Bohacek R, Fisher RS. 1987. Tiletamine Is A Poten Inhibitor of N-Methyl-Aspartate Induced Depolarization in Rat Hippocampus and Striatum. J.Pharmacol, Exp. Ther. 243 (3): 915-200. (Medline).

Mutschler E. 1991. Dinamika Obat. Edisi 5. Diterjemahkan oleh Widianto MB dan A.S. Ranti. Bandung. Penerbit ITB.

Plumb DC. 2002. Veterinary Drug Handbook 4th Ed. USA. Iowa State Press.

Sardjana IKW, Kusumawati D. 2004. Anestesi Veteriner Jilid I. Yogyakarta. Gadjah Mada University Press. Bulaksumur, p.1-49.

Slatter D. 2003. Textbook of Small Animal Surgery Volume 2 3th edition. Philadelpia. Sounders, An Inprint of Elsevier Science.

Stoelting H. 2006. Pharmacology and Physiology in Anesthetic Practice. 4th Ed. Philadelpia: Williams and Wilkins.
Susilo A. 2009. Manajemen dan Penelitian Kesehatan dengan Hewan Coba. Jakarta.Warta UII.

Wilson RP, ZagonLS, LaracchDR, Lang CM. 1993. Cardivascular andRespiratory Effect of Tiletamin-Zolazepam. Pharmacol. Biochem. Behav. 44(1): 1-8. (Medline).

Zulnida DS, Elysabeth. 2012. Anestesi umum dalam Farmakologi dan Terapi edisi V. Jakarta: Badan Penerbit FKUI.

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Published
2019-06-01
How to Cite
Yunani, R., Mudji, E., & Apritya, D. (2019). PERBEDAAN EFEKTIVITAS ANESTETIKUM ANTARA ZOLETILACEPROMACIN DAN KETAMIN- ACEPROMACIN PADA TIKUS PUTIH (Rattus norvegicus). JURNAL KAJIAN VETERINER, 3(2), 113-119. https://doi.org/10.35508/jkv.v3i2.1036
Issue
Vol 3 No 2 (2015): Jurnal Kajian Veteriner
Section
Articles

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