Efektifitas Amniotic Membrane Sebagai Dressing Penyembuhan Luka Bakar Pada Tikus Putih (Rattus Norvegicus)
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Ratna Widyawati(1*)
Laboratorium Klinik Veteriner Fakultas Kedokteran Hewan UWKS
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Desty Apritya(2)
Laboratorium Klinik Veteriner Fakultas Kedokteran Hewan UWKS
(*) Corresponding Author
Keywords:
Amniotic membrane, propolis, wounds healing, rats
Abstract
This study aimed to determine the effectiveness of the speed the healing of burns used amniotic membrane by propolis and propolis amniotic membrane without white rats (Rattus norvegicus). This study was an experimental study with the technique of sampling by completely randomized design. The variables measured were the speed of healing old wounds and wound healing time (days). This study used 30 rats were divided into 4 groups. The group (P1) as a negative control, the White Rat (Rattus norvegicus) wrapped in sterile gauze, group (P2) as a positive control, the White Rat (Rattus norvegicus) by betadine and wrapped in sterile gauze. The group (P3) Rats (Rattus norvegicus) wrapped with amniotic membrane + sterile gauze and groups (P4) Rats (Rattus norvegicus) + propolis + + gauze sterile amniotic membrane. The result showed that Speeds healing of burns negative kontrol, PI and P2 there are differences, also between PI and P2. Between control positive and PI showed not difference. It can show from some indications that include wet or dryness of the wound, whether there is swelling in the wound, the wound color (red or white), linkage outskirts of injuries, whether there is a scab, and the open or closed wounds, but the long time healing wounds (day) are different, PI and kontrol positive are the best result, they are nine days.
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References
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Robbson MC and Krizek TJ. The Effect of Human Amniotic Membrane on The Bacterial Population on Infected Rat Burns. Annals Surgeons. 177th Ed.1973 : 144-149.
Susilo I, 2011, Effect Of Topical Hyalunorate and Freeze-Dried Amnion Membrane Administration on CK 16 Protein Expression and The Number of Epithelial Layer in Superficial Wound of Male Wistar Strain Rats. Folica Medica Indonesiana Vol 47 No 2 : Hal 137-42
Warganegara E, Etty A, dan Ryan A.2012. Identifikasi Bakteri Penyebab Infeksi Luka Operasi (Ilo) Nosokomial Pada Ruang Rawat Inap Bedah Dan Kebidanan Rsam Di Bandar Lampung. Fakultas Kedokteran Universitas Lampung. Prosiding SNSMAIP III-2012 ISBN No. 978-602-98559-1-3
Widiartini,W. Eka S. Ana S. Ita M R. Eko P. 2013. Pengembangan Usaha Produksi Tikus Putih (Rattus Norvegicus)Tersertifikasi Dalam Upaya Memenuhi Kebutuhan Hewan Laboratorium. Fakultas Peternakan dan Pertanian, Universitas Diponegoro.Semarang.http://artikel.dikti.go.id/index.php/PKMK/article/download/149/150
Yovita, S. 2012. Penanganan Luka Bakar. Artikel: http://www1-media.acehprov.go.id/uploads/PENANGANAN_LUKA_BAKAR.pdf diunduh pada 1 Maret 2015
Bose B. Burns Wound Dressing with Human Amniotic Membranes. Annals of The Royal College of Surgeon.England. 61st Ed. 1979 : 444-447.
Brunicardi F C, Anderson D, Dunn DL. 2005. Schwartz’s Principles of surgery. 8 edition.New York: McGraw-Hill Medical Publishing.
Fitria, M., Deddy S, Gusti R. 2014. Pengaruh Papain Getah Pepaya Terhadap Pembentukan Jaringan Granulasi pada Penyembuhan Luka Bakar Tikus Percobaan. Fakultas Kedokteran Universitas Andalas, Bagian Ilmu Bedah FK Unand, Bagian Anatomi Fakultas Kedokteran Universitas Andalas. Jurnal Kesehatan Andalas. 2014; 3(1). Jurnal Medika Veterinaria ISSN : 0853-1943
Francisco, J C., Ricardo C C, Rossana B S, Luiz C G-S, Reginaldo J F, Ana C I, Carolina M C. Oliveira S, Garikipati V N S, Soniya N, Juan C C, Katherine A T C. 2013. Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue. J. Biomedical Science and Engineering Biomedical Science and Engineering 6 (2013) 1178-1185
Gorda, I W., Soma I G, Dharmayudha, AAGO.2011. The Influence of honey in the incision wound recovery in mice (Mus musculus). Faculty of Veterinary Medicine Udayana University, Jl. PB Sudirman- Denpasar. Disampaikan dalam kongres Nasional Pertama Asosiasi Farmakologi dan Farmasi Veteriner Indonesia 26 Maret 2011
Gruss J S, et al. Human Amniotic Membrane : A Versatile Wound Dressing. CMA.Journal. 118th Ed. 1978 : 1237-1254.
Handaya Y. 2011. Luka Bakar dan Kontraktur. General and laparascopic Surgeon. Dokter Spesialis Bedah Kabupaten Malang. http://dokteryudabedah.com/wp-content/uploads/2011/03/Lengkap-Tentang-Luka-Bakar.pdf diakses pada tanggal 16 Maret 2015
Heberal M, Oner Z, Bayraktar U, bilgin N. 2013. The use of silver nitrate-incorporated amniotic membrane as a temporary dressing. Copyright 2013 Elsevier Ltd and ISBI.PMID 3580940 (PubMed –indexed for MEDLINE). Burns.2013 Sep ; 39(6): 1137-41. Doi:10.1016/j.burns.2013.01.017.Epub 2013 Mar 21
Kane, V.2014. Antiseptik. Artikel : Kerjanya.net http://www.kerjanya.net/faq/5011-antiseptik.html diakses pada tanggal 15 November 2016
Listyasari, N A.2012. Pengaruh Pasta Gigi Dengan Kandungan Propolis Terhadap Pembentukan Plak Gigi. Laporan Akhir Hasil Penelitian Karya Tulis Ilmiah. Program Pendidikan Sarjana Kedokteran Fakultas Kedokteran Universitas Diponegoro. http://eprints.undip.ac.id/37645/1/Nurin_Aisyiyah_L_-_G2A008132_-_LAPORAN_KTI.pdf diakses pada tanggal 4 April 2015
Martinotti S, Elia R.2015.Propolis: a new frontier for wound healing? Review Martinotti and Ranzato Burn & Trauma (2015) 3:9 DOI 10.1186/s41038-015-0010-z.
Matthews R, Bennett J, Page Faulk W. Wound healing using amniotic membranes. British Journal of Plastic Surgery. 1981;34:76-8.
Molan P.C. The evidence supporting the use of honey as a wound dressing. The International Journal of Lower Extremity Wounds. 2006; 5(1) : 40-54 Noer, M S. 2012. Management Acute Phase In Burn. Departemen / SMF Bedah Plastik Rekonstruksi dan Estetik FK Universitas Airlangga - RSUD Dr. Soetomo Surabaya. Jurnal Medika Veterinaria ISSN : 0853-1943 9 Papini, R.2004. Management of Burn Injuries of Various Depths. Clinical Review ABCofBurns.BMJ 2004; 329 doi:http://dx.doi.org/10.1136/bmj.329.7458.158 (Published 15 July 2004)Cite this as: BMJ 2004;329:158
Robbson MC and Krizek TJ. The Effect of Human Amniotic Membrane on The Bacterial Population on Infected Rat Burns. Annals Surgeons. 177th Ed.1973 : 144-149.
Susilo I, 2011, Effect Of Topical Hyalunorate and Freeze-Dried Amnion Membrane Administration on CK 16 Protein Expression and The Number of Epithelial Layer in Superficial Wound of Male Wistar Strain Rats. Folica Medica Indonesiana Vol 47 No 2 : Hal 137-42
Warganegara E, Etty A, dan Ryan A.2012. Identifikasi Bakteri Penyebab Infeksi Luka Operasi (Ilo) Nosokomial Pada Ruang Rawat Inap Bedah Dan Kebidanan Rsam Di Bandar Lampung. Fakultas Kedokteran Universitas Lampung. Prosiding SNSMAIP III-2012 ISBN No. 978-602-98559-1-3
Widiartini,W. Eka S. Ana S. Ita M R. Eko P. 2013. Pengembangan Usaha Produksi Tikus Putih (Rattus Norvegicus)Tersertifikasi Dalam Upaya Memenuhi Kebutuhan Hewan Laboratorium. Fakultas Peternakan dan Pertanian, Universitas Diponegoro.Semarang.http://artikel.dikti.go.id/index.php/PKMK/article/download/149/150
Yovita, S. 2012. Penanganan Luka Bakar. Artikel: http://www1-media.acehprov.go.id/uploads/PENANGANAN_LUKA_BAKAR.pdf diunduh pada 1 Maret 2015
Published
2019-06-01
How to Cite
Widyawati, R., & Apritya, D. (2019). Efektifitas Amniotic Membrane Sebagai Dressing Penyembuhan Luka Bakar Pada Tikus Putih (Rattus Norvegicus). JURNAL KAJIAN VETERINER, 4(2), 10-20. https://doi.org/10.35508/jkv.v4i2.1016
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