Peranan Pendekatan Molekular dalam Program Eradikasi Penyakit Mulut dan Kuku
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Maria Aega Gelolodo(1*)
Bagian Ilmu Penyakit Hewan dan Kesehatan Masyarakat Veteriner Fakultas Kedokteran Hewan Universitas Nusa Cendana
(*) Corresponding Author
Keywords:
PMK, molecular, eradication, DIVA
Abstract
Penyakit Mulut dan Kuku (PMK) adalah salah satu penyakit penting yang menginfeksi hewan sapi, kambing, domba dan babi serta beberapa jenis hewan liar. Penyakit ini penting secara ekonomi karena selain mengakibatkan angka mortalitas yang tinggi pada hewan muda, penurunan produksi susu maupun bahan asal hewan lainnya serta dapat mengakibatkan pembatasan perdagangan internasional bagi negara yang terinfeksi PMK. Selain dampak langsung dari penurunan produksi peternkan dan pembatasan perdagangan internasional, wabah PMK juga memberikan dampak yang serius bagi aspek sosial ekonomi dan industri pariwisata. Sampai saat ini, penyakit ini menyebar luas di Amerika selatan, Asia dan Africa. Mengingat arti pentingnya penyakit ini dan dampaknya secara global, maka penting untuk menyusun langkah strategis pencegahan dan eradikasi penyakit ini. Tulisan ini akan membahas beberapa langkah strategis penting yang dapat dimplementasikan dalam program eradikasi PMK khususnya melalui kegiatan-kegiatan yang berbasis teknologi molecular mulai dari penyiapan vaksin, tes diagnostic sampai kegiatan monitoring status penyakit.
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References
Abdul-Hamid, N.F., Hussein, N.M., Wadsworth, J., Radford, A.D., Knowles, N.J. and King, D.P. (2011) Phylogeography of foot-and-mouth disease virus types O and A in Malaysia and surrounding countries. Infect Genet Evol 11: 320-8
Alexandersen, S. and Mowat, N. (2005) Foot-and-mouth disease: host range and pathogenesis. Curr Top Microbiol Immunol 288: 9-42
Alexandersen, S., Quan, M., Murphy, C., Knight, J. and Zhang, Z. (2003a) Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. J Comp Pathol 129: 268-82
Alexandersen, S., Zhang, Z., Donaldson, A.I. and Garland, A.J.M. (2003b) The Pathogenesis and Diagnosis of Foot-and-Mouth Disease. Journal of Comparative Pathology 129: 1-36
Bao, H.F., Li, D., Guo, J.H., Lu, Z.J., Chen, Y.L., Liu, Z.X., Liu, X.T. and Xie, Q.G. (2008) A highly sensitive and specific multiplex RT-PCR to detect foot-and-mouth disease virus in tissue and food samples. Arch Virol 153: 205-9
Brehm, K.E., Kumar, N., Thulke, H.H. and Haas, B. (2008) High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus. Vaccine 26: 1681-1687
Bruderer, U., Swam, H., Haas, B., Visser, N., Brocchi, E., Grazioli, S., Esterhuysen, J.J., Vosloo, W., Forsyth, M., Aggarwal, N., Cox, S., Armstrong, R. and Anderson, J. (2004) Differentiating infection from vaccination in foot-and-mouth-disease: evaluation of an ELISA based on recombinant 3ABC. Veterinary Microbiology 101: 187-197
Chung, W.B., Liao, P.C., Yang, P.C., Chen, S.P., Jong, M.H. and Sheu, T.W. (2003) Surveillance of FMD virus non-structural protein antibodies in pig populations involved in an eradication programme. Vet Rec 152: 595-7
Clavijo, A., Wright, P. and Kitching, P. (2004) Developments in diagnostic techniques for differentiating infection from vaccination in foot-and-mouth disease. The Veterinary Journal 167: 9-22
Doel, T.R. (2003) FMD vaccines. Virus Research 91: 81-99
Dundon, W.G., Haas, B., Parida, S., Paton, D.J., Rasmussen, T.B. and Uttenthal, A. (2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Review of Vaccines 9: 73+
Foord, A.J., Muller, J.D., Yu, M., Wang, L.F. and Heine, H.G. (2007) Production and application of recombinant antibodies to foot-and-mouth disease virus non-structural protein 3ABC. J Immunol Methods 321: 142-51
Giridharan, P., Hemadri, D., Tosh, C., Sanyal, A. and Bandyopadhyay, S.K. (2005) Development and evaluation of a multiplex PCR for differentiation of foot-and-mouth disease virus strains native to India. J Virol Methods 126: 1-11
Gleeson, L.J. (2002) A review of the status of foot and mouth disease in South-East Asia and approaches to control and eradication. Rev Sci Tech 21: 465-75
Jamal, S.M. and Belsham, G.J. (2013) Foot-and-mouth disease: past, present and future. Vet Res 44: 116
Kitching, P., Hammond, J., Jeggo, M., Charleston, B., Paton, D., Rodriguez, L. and Heckert, R. (2007) Global FMD control--is it an option? Vaccine 25: 5660-4
Kitching, R.P. and Alexandersen, S. (2002) Clinical variation in foot and mouth disease: pigs. Rev Sci Tech 21: 513-8
Klein, J. (2009) Understanding the molecular epidemiology of foot-and-mouth-disease virus. Infect Genet Evol 9: 153-61
Knowles, N.J. and Samuel, A.R. (2003) Molecular epidemiology of foot-and-mouth disease virus. Virus Research 91: 65-80
Le, V.P., Lee, K.N., Nguyen, T., Kim, S.M., Cho, I.S., Khang, D.D., Hien, N.B., Van Quyen, D. and Park, J.H. (2012) A rapid molecular strategy for early detection and characterization of Vietnamese foot-and-mouth disease virus serotypes O, A, and Asia 1. J Virol Methods 180: 1-6
Ma, L.N., Zhang, J., Chen, H.T., Zhou, J.H., Ding, Y.Z. and Liu, Y.S. (2011) An overview on ELISA techniques for FMD. Virol J 8: 419
Muller, J.D., Wilkins, M., Foord, A.J., Dolezal, O., Yu, M., Heine, H.G. and Wang, L.-F. (2010) Improvement of a recombinant antibody-based serological assay for foot-and-mouth disease virus. Journal of Immunological Methods 352: 81-88
OIE. (2012) Foot and mouth disease. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals
Parida, S. (2009) Vaccination against foot-and-mouth disease virus: strategies and effectiveness. Expert Review of Vaccines 8: 347+
Parida, S., Anderson, J., Cox, S.J., Barnett, P.V. and Paton, D.J. (2006a) Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24: 1107-16
Parida, S., Oh, Y., Reid, S.M., Cox, S.J., Statham, R.J., Mahapatra, M., Anderson, J., Barnett, P.V., Charleston, B. and Paton, D.J. (2006b) Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV. Vaccine 24: 964-9
Paton, D.J., Valarcher, J.F., Bergmann, I., Matlho, O.G., Zakharov, V.M., Palma, E.L. and Thomson, G.R. (2005) Selection of foot and mouth disease vaccine strains--a review. Rev Sci Tech 24: 981-93
Reid, S.M., Ferris, N.P., Hutchings, G.H., Zhang, Z., Belsham, G.J. and Alexandersen, S. (2002) Detection of all seven serotypes of foot-and-mouth disease virus by real-time, fluorogenic reverse transcription polymerase chain reaction assay. Journal of Virological Methods 105: 67-80
Reid, S.M., Grierson, S.S., Ferris, N.P., Hutchings, G.H. and Alexandersen, S. (2003) Evaluation of automated RT-PCR to accelerate the laboratory diagnosis of foot-and-mouth disease virus. Journal of Virological Methods 107: 129-139
Rweyemamu, M., Roeder, P., Mackay, D., Sumption, K., Brownlie, J., Leforban, Y., Valarcher, J.F., Knowles, N.J. and Saraiva, V. (2008) Epidemiological Patterns of Foot-and-Mouth Disease Worldwide. Transboundary and Emerging Diseases 55: 57-72
Sariya, L., Thangthumniyom, N., Wajjwalku, W., Chumsing, W., Ramasoota, P. and Lekcharoensuk, P. (2011) Expression of foot and mouth disease virus nonstructural polyprotein 3ABC with inactive 3Cpro in Escherichia coli. Protein Expression and Purification 80: 17-21
Sharma, G.K., Mohapatra, J.K., Pandey, L.K., Mahajan, S., Mathapati, B.S., Sanyal, A. and Pattnaik, B. (2012) Immunodiagnosis of foot-and-mouth disease using mutated recombinant 3ABC polyprotein in a competitive ELISA. Journal of Virological Methods 185: 52-60
Uttenthal, A., Parida, S., Rasmussen, T.B., Paton, D.J., Haas, B. and Dundon, W.G. (2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Rev Vaccines 9: 73-87
Alexandersen, S. and Mowat, N. (2005) Foot-and-mouth disease: host range and pathogenesis. Curr Top Microbiol Immunol 288: 9-42
Alexandersen, S., Quan, M., Murphy, C., Knight, J. and Zhang, Z. (2003a) Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. J Comp Pathol 129: 268-82
Alexandersen, S., Zhang, Z., Donaldson, A.I. and Garland, A.J.M. (2003b) The Pathogenesis and Diagnosis of Foot-and-Mouth Disease. Journal of Comparative Pathology 129: 1-36
Bao, H.F., Li, D., Guo, J.H., Lu, Z.J., Chen, Y.L., Liu, Z.X., Liu, X.T. and Xie, Q.G. (2008) A highly sensitive and specific multiplex RT-PCR to detect foot-and-mouth disease virus in tissue and food samples. Arch Virol 153: 205-9
Brehm, K.E., Kumar, N., Thulke, H.H. and Haas, B. (2008) High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus. Vaccine 26: 1681-1687
Bruderer, U., Swam, H., Haas, B., Visser, N., Brocchi, E., Grazioli, S., Esterhuysen, J.J., Vosloo, W., Forsyth, M., Aggarwal, N., Cox, S., Armstrong, R. and Anderson, J. (2004) Differentiating infection from vaccination in foot-and-mouth-disease: evaluation of an ELISA based on recombinant 3ABC. Veterinary Microbiology 101: 187-197
Chung, W.B., Liao, P.C., Yang, P.C., Chen, S.P., Jong, M.H. and Sheu, T.W. (2003) Surveillance of FMD virus non-structural protein antibodies in pig populations involved in an eradication programme. Vet Rec 152: 595-7
Clavijo, A., Wright, P. and Kitching, P. (2004) Developments in diagnostic techniques for differentiating infection from vaccination in foot-and-mouth disease. The Veterinary Journal 167: 9-22
Doel, T.R. (2003) FMD vaccines. Virus Research 91: 81-99
Dundon, W.G., Haas, B., Parida, S., Paton, D.J., Rasmussen, T.B. and Uttenthal, A. (2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Review of Vaccines 9: 73+
Foord, A.J., Muller, J.D., Yu, M., Wang, L.F. and Heine, H.G. (2007) Production and application of recombinant antibodies to foot-and-mouth disease virus non-structural protein 3ABC. J Immunol Methods 321: 142-51
Giridharan, P., Hemadri, D., Tosh, C., Sanyal, A. and Bandyopadhyay, S.K. (2005) Development and evaluation of a multiplex PCR for differentiation of foot-and-mouth disease virus strains native to India. J Virol Methods 126: 1-11
Gleeson, L.J. (2002) A review of the status of foot and mouth disease in South-East Asia and approaches to control and eradication. Rev Sci Tech 21: 465-75
Jamal, S.M. and Belsham, G.J. (2013) Foot-and-mouth disease: past, present and future. Vet Res 44: 116
Kitching, P., Hammond, J., Jeggo, M., Charleston, B., Paton, D., Rodriguez, L. and Heckert, R. (2007) Global FMD control--is it an option? Vaccine 25: 5660-4
Kitching, R.P. and Alexandersen, S. (2002) Clinical variation in foot and mouth disease: pigs. Rev Sci Tech 21: 513-8
Klein, J. (2009) Understanding the molecular epidemiology of foot-and-mouth-disease virus. Infect Genet Evol 9: 153-61
Knowles, N.J. and Samuel, A.R. (2003) Molecular epidemiology of foot-and-mouth disease virus. Virus Research 91: 65-80
Le, V.P., Lee, K.N., Nguyen, T., Kim, S.M., Cho, I.S., Khang, D.D., Hien, N.B., Van Quyen, D. and Park, J.H. (2012) A rapid molecular strategy for early detection and characterization of Vietnamese foot-and-mouth disease virus serotypes O, A, and Asia 1. J Virol Methods 180: 1-6
Ma, L.N., Zhang, J., Chen, H.T., Zhou, J.H., Ding, Y.Z. and Liu, Y.S. (2011) An overview on ELISA techniques for FMD. Virol J 8: 419
Muller, J.D., Wilkins, M., Foord, A.J., Dolezal, O., Yu, M., Heine, H.G. and Wang, L.-F. (2010) Improvement of a recombinant antibody-based serological assay for foot-and-mouth disease virus. Journal of Immunological Methods 352: 81-88
OIE. (2012) Foot and mouth disease. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals
Parida, S. (2009) Vaccination against foot-and-mouth disease virus: strategies and effectiveness. Expert Review of Vaccines 8: 347+
Parida, S., Anderson, J., Cox, S.J., Barnett, P.V. and Paton, D.J. (2006a) Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24: 1107-16
Parida, S., Oh, Y., Reid, S.M., Cox, S.J., Statham, R.J., Mahapatra, M., Anderson, J., Barnett, P.V., Charleston, B. and Paton, D.J. (2006b) Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV. Vaccine 24: 964-9
Paton, D.J., Valarcher, J.F., Bergmann, I., Matlho, O.G., Zakharov, V.M., Palma, E.L. and Thomson, G.R. (2005) Selection of foot and mouth disease vaccine strains--a review. Rev Sci Tech 24: 981-93
Reid, S.M., Ferris, N.P., Hutchings, G.H., Zhang, Z., Belsham, G.J. and Alexandersen, S. (2002) Detection of all seven serotypes of foot-and-mouth disease virus by real-time, fluorogenic reverse transcription polymerase chain reaction assay. Journal of Virological Methods 105: 67-80
Reid, S.M., Grierson, S.S., Ferris, N.P., Hutchings, G.H. and Alexandersen, S. (2003) Evaluation of automated RT-PCR to accelerate the laboratory diagnosis of foot-and-mouth disease virus. Journal of Virological Methods 107: 129-139
Rweyemamu, M., Roeder, P., Mackay, D., Sumption, K., Brownlie, J., Leforban, Y., Valarcher, J.F., Knowles, N.J. and Saraiva, V. (2008) Epidemiological Patterns of Foot-and-Mouth Disease Worldwide. Transboundary and Emerging Diseases 55: 57-72
Sariya, L., Thangthumniyom, N., Wajjwalku, W., Chumsing, W., Ramasoota, P. and Lekcharoensuk, P. (2011) Expression of foot and mouth disease virus nonstructural polyprotein 3ABC with inactive 3Cpro in Escherichia coli. Protein Expression and Purification 80: 17-21
Sharma, G.K., Mohapatra, J.K., Pandey, L.K., Mahajan, S., Mathapati, B.S., Sanyal, A. and Pattnaik, B. (2012) Immunodiagnosis of foot-and-mouth disease using mutated recombinant 3ABC polyprotein in a competitive ELISA. Journal of Virological Methods 185: 52-60
Uttenthal, A., Parida, S., Rasmussen, T.B., Paton, D.J., Haas, B. and Dundon, W.G. (2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease, classical swine fever and avian influenza. Expert Rev Vaccines 9: 73-87
Published
2019-06-01
How to Cite
Gelolodo, M. (2019). Peranan Pendekatan Molekular dalam Program Eradikasi Penyakit Mulut dan Kuku. JURNAL KAJIAN VETERINER, 5(1), 21-42. https://doi.org/10.35508/jkv.v5i1.1022
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Articles
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