Tinjauan Vibrio Vulnificus sebagai Ancaman Emerging Foodborne Disease pada Makanan Laut Segar
Review of Vibrio Vulnificus as an Emerging Foodborne Disease Threat in Raw Seafood
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Maxs U. E. Sanam(1)
Departemen Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran dan Kedokteran Hewan, Universitas Nusa Cendana, Kupang
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Maria Aega Gelolodo(2*)
Departemen Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran dan Kedokteran Hewan, Universitas Nusa Cendana, Kupang
https://orcid.org/0000-0002-8912-5779
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Elisabet Tangkonda(3)
Departemen Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran dan Kedokteran Hewan, Universitas Nusa Cendana, Kupang
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Fhady R. Loe(4)
Departemen Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran dan Kedokteran Hewan, Universitas Nusa Cendana, Kupang
(*) Corresponding Author
Keywords:
food-borne disease, raw seafood, septicemia, Vibrio vulnificus, wound infections
Abstract
Vibrio vulnificus is a crucial foodborne opportunistic pathogen that can cause wound infections, septicemia, and gastroenteritis with a 50% fatality rate. This bacteria occurs in estuaries and coastal waters and is found in large quantities in oysters and other mollusc shells. The increasing number of foodborne diseases worldwide is suspected to have occurred due to the expansion of the international food trade. Consumption of raw seafood, especially oysters containing Vibrio vulnificus bacteria, can result in acute, severe systemic infections and is responsible for 95% of deaths from seafood consumption in the United States. The diagnosis of Vibrio vulnificus infection is confirmed by the growth of the bacteria in culture media from wounds, feces or blood. This article discusses the characteristics of the bacteria, host, environment, transmission, pathogenesis, clinical symptoms, diagnostic techniques and geographical distribution of V. vulnificus.
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References
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Crim, S. M., Iwamoto, M., Huang, J. Y., Griffin, P. M., Gilliss, D., Cronquist, A. B., … Henao, O. L. (2014). Incidence and Trends of Infection with Pathogens Transmitted Commonly Through Food — Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2006–2013. MMWR. Morbidity and Mortality Weekly Report, 63(15), 328–332. https://doi.org/mm6315a1 [pii]
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Farisi, S., Widiastuti, E. L., Suratman, S., Saputra, H. R., & Kanedi, M. (2022). Identification of bacteria causing Vibriosis (Vibrio sp) on white snapper (Lates calcarifer) reared in the marine cultivation ponds. Retrived from http://repository.lppm.unila.ac.id/45889/
França, J. C. B., Raboni, S. M., Sanfelice, E., Polido, D., Gentili, A., & Marques, F. (2013). Vibrio vulnificus infection in Southern Brazil -- case report. Anais Brasileiros de Dermatologia, 88(3), 424–426. https://doi.org/10.1590/abd1806-4841.20131780
Froelich, B. A., Phippen, B., Fowler, P., Noble, R. T., & Oliver, J. D. (2017). crossm Differences in Abundances of Total in North Carolina, 83(2), 1–11.
Hernández‐Cabanyero, C., & Amaro, C. (2020). Phylogeny and life cycle of the zoonotic pathogen Vibrio vulnificus. Environmental Microbiology, 22(10), 4133-4148.
Hikmawati, F., Susilowati, A., & Setyaningsih, R. (2019). Colony morphology and molecular identification of Vibrio spp. on green mussels (Perna viridis) in Yogyakarta, Indonesia tourism beach areas. Biodiversitas Journal of Biological Diversity, 20(10).
Hor, L. I., & Chen, C. L. (2013). Cytotoxins of Vibrio vulnificus: Functions and roles in pathogenesis. BioMedicine (Netherlands), 3(1), 19–26. https://doi.org/10.1016/j.biomed.2012.12.003
Horseman, M. A., & Surani, S. (2011). A comprehensive review of Vibrio vulnificus: An important cause of severe sepsis and skin and soft-tissue infection. International Journal of Infectious Diseases, 15(3), e157–e166. https://doi.org/10.1016/j.ijid.2010.11.003
Inoue Y, Ono T, Matsui T, Miyasaka J, Kinoshita Y, Ihn H (2008) Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003. J Dermatol 35(3):129–139. https://doi.org/10.1111/j.1346-8138.2008.00432.x
Jeong, H. S., Kim, J. Y., Jeon, S. M., Park, M. S., & Kimb, S. H. (2011). genotypic characterization of Vibrio vulnificus clinical isolates in Korea. Osong Public Health and Research Perspectives, 2(1), 8–14. https://doi.org/10.1016/j.phrp.2011.04.008
Jones, M. K., & Oliver, J. D. (2009). Vibrio vulnificus: Disease and pathogenesis. Infection and Immunity, 77(5), 1723–1733. https://doi.org/10.1128/IAI.01046-08
Kim WB, Lee BC, Choi SH (2012) Vibrio vulnificus AphB is involved in interleukin-8 production via an NF-kappaB-dependent pathway in human intestinal epithelial cells. Biochem Biophys Res Commun 417(4):1265–1270. https://doi.org/10.1016/j.bbrc.2011.12.122
Koton, Y., Gordon, M., Chalifa-Caspi, V., and Bisharat, N. (2015) Comparative genomic analysis of clinical and environmental Vibrio vulnificus isolates revealed biotype 3 evolutionary relationships. Front Microbiol 5: 1–10.
Lee SJ, Jung YH, Oh SY, Song EJ, Choi SH, Han HJ (2015) Vibrio vulnificus VvhA induces NF-kappaB-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells. Cell Death Dis 6:1655. https://doi.org/10.1038/cddis.2015.19
Lee NY, Lee HY, Lee KH, Han SH, Park SJ (2011) Vibrio vulnificus IlpA induces MAPK-mediated cytokine production via TLR1/2
activation in THP-1 cells, a human monocytic cell line. Mol Immunol 49(1–2):143–154.
Leng, F., Lin, S., Wu, W., Zhang, J., Song, J., & Zhong, M. (2019). Epidemiology, pathogenetic mechanism, clinical characteristics, and treatment of Vibrio vulnificus infection: a case report and literature review. European Journal of Clinical Microbiology & Infectious Diseases, 38, 1999-2004.
Liu M, Crosa JH (2012) The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections. MicrobiologyOpen 1(4):502–513. https://doi.org/10.1002/mbo3.48
Matsuoka, Y., Nakayama, Y., Yamada, T., Nakagawachi, A., Matsumoto, K., Nakamura, K., … Sakaguchi, Y. (2013). Accurate diagnosis and treatment of Vibrio vulnificus infection: A retrospective study of 12 cases. Brazilian Journal of Infectious Diseases, 17(1), 7–12. https://doi.org/10.1016/j.bjid.2012.07.017
Nakashima, Y., Oho, M., Kusaba, K., Nagasawa, Z., Komatsu, O., Manome, I., … Nakashima, M. (2007). A Chromogenic Substrate Culture Plate for Early Identification of Vibrio vulnificus and Isolation of Other Marine Vibrios, 37(4), 330–334.
Novoslavskij, A., Terentjeva, M., Eizenberga, I., Valciņa, O., Bartkevičs, V., & Bērziņš, A. (2016). Major foodborne pathogens in fish and fish products: a review. Annals of Microbiology, 66(1), 1–15. https://doi.org/10.1007/s13213-015-1102-5
Oliver, J. D., & Jones, J. L. (2015). Chapter 66 – Vibrio parahaemolyticus and Vibrio vulnificus. In Molecular Medical Microbiology (pp. 1169–1186). https://doi.org/10.1016/B978-0-12-397169-2.00066-4
Oliver, J.D. (2015) The biology of Vibrio vulnificus. Microbiol Spectr 3: 1–10.
Pajuelo D, Hernandez-Cabanyero C, Sanjuan E, Lee CT, Silva-Hernandez FX, Hor LI, MacKenzie S, Amaro C (2016) Iron and Fur in the life cycle of the zoonotic pathogen Vibrio vulnificus. Environ Microbiol 18(11):4005–4022. https://doi.org/10.1111/1462-2920.13424
Phillips, K. E., & Satchell, K. J. F. (2017). Vibrio vulnificus : From Oyster Colonist to Human Pathogen, 1(C), 1–5. https://doi.org/10.1371/journal.ppat.1006053
Putri, N. F. A., Wardani, A. K., & Harsojo. (2015). Aplikasi
teknologi iradiasi Gamma dan penyimpanan beku sebagai upaya penurunan bakteri patogen pada Seafood : kajian pustaka. Jurnal Pangan Dan Agroindustri, 3(2), 345–352.
Raszl, S. M., Froelich, B. A., Vieira, C. R. W., Blackwood, A. D., & Noble, R. T. (2016). Vibrio parahaemolyticus and Vibrio vulnificus in South America: water, seafood and human infections. Journal of Applied Microbiology, 121(5), 1201–1222. https://doi.org/10.1111/jam.13246
Roig, F.J., González-Candelas, F., Sanjuán, E., Fouz, B., Feil, E.J., Llorens, C., et al. (2018) Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy. Front Microbiol 8: 1–13.
Shapiro RL, Altekruse S, Hutwagner L, Bishop R, Hammond R, Wilson S, Ray B, Thompson S, Tauxe RV, Griffin PM (1998) The role of Gulf Coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States, 1988-1996. Vibrio Working Group. J Infect Dis 178(3):752–759
Song EJ, Lee SJ, Lim HS, Kim JS, Jang KK, Choi SH, Han HJ (2016) Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway. Sci Rep 6:27080. https://doi.org/10.1038/srep27080
Yu, W., Shen, X., Pan, H., Xiao, T., Shen, P., & Xiao, Y. (2017). Clinical features and treatment of patients with Vibrio vulnificus infection. International Journal of Infectious Diseases, 59, 1–6. https://doi.org/10.1016/j.ijid.2017.03.017
Baker-Austin, C., & Oliver, J. D. (2020). Vibrio vulnificus. Trends in microbiology, 28(1), 81–82. https://doi.org/10.1016/j.tim.2019.08.006
Conrad, J. (2014). Characterization of Vibrio vulnificus strains using phenotypic and genotypic assays, 109. Retrieved from http://commons.lib.jmu.edu/cgi/viewcontent.cgi?article=1010&context=master201019
Crim, S. M., Iwamoto, M., Huang, J. Y., Griffin, P. M., Gilliss, D., Cronquist, A. B., … Henao, O. L. (2014). Incidence and Trends of Infection with Pathogens Transmitted Commonly Through Food — Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2006–2013. MMWR. Morbidity and Mortality Weekly Report, 63(15), 328–332. https://doi.org/mm6315a1 [pii]
Dib, A. L., Chahed, A., Elgroud, R., Kabouia, R., Bouaziz, O., García, M. E., … Constantine, U. M. (2013). Evaluation of the contamination of sea products by Vibrio and other bacteria in the eastern coast of Algeria, 5(3), 66–73.
Farisi, S., Widiastuti, E. L., Suratman, S., Saputra, H. R., & Kanedi, M. (2022). Identification of bacteria causing Vibriosis (Vibrio sp) on white snapper (Lates calcarifer) reared in the marine cultivation ponds. Retrived from http://repository.lppm.unila.ac.id/45889/
França, J. C. B., Raboni, S. M., Sanfelice, E., Polido, D., Gentili, A., & Marques, F. (2013). Vibrio vulnificus infection in Southern Brazil -- case report. Anais Brasileiros de Dermatologia, 88(3), 424–426. https://doi.org/10.1590/abd1806-4841.20131780
Froelich, B. A., Phippen, B., Fowler, P., Noble, R. T., & Oliver, J. D. (2017). crossm Differences in Abundances of Total in North Carolina, 83(2), 1–11.
Hernández‐Cabanyero, C., & Amaro, C. (2020). Phylogeny and life cycle of the zoonotic pathogen Vibrio vulnificus. Environmental Microbiology, 22(10), 4133-4148.
Hikmawati, F., Susilowati, A., & Setyaningsih, R. (2019). Colony morphology and molecular identification of Vibrio spp. on green mussels (Perna viridis) in Yogyakarta, Indonesia tourism beach areas. Biodiversitas Journal of Biological Diversity, 20(10).
Hor, L. I., & Chen, C. L. (2013). Cytotoxins of Vibrio vulnificus: Functions and roles in pathogenesis. BioMedicine (Netherlands), 3(1), 19–26. https://doi.org/10.1016/j.biomed.2012.12.003
Horseman, M. A., & Surani, S. (2011). A comprehensive review of Vibrio vulnificus: An important cause of severe sepsis and skin and soft-tissue infection. International Journal of Infectious Diseases, 15(3), e157–e166. https://doi.org/10.1016/j.ijid.2010.11.003
Inoue Y, Ono T, Matsui T, Miyasaka J, Kinoshita Y, Ihn H (2008) Epidemiological survey of Vibrio vulnificus infection in Japan between 1999 and 2003. J Dermatol 35(3):129–139. https://doi.org/10.1111/j.1346-8138.2008.00432.x
Jeong, H. S., Kim, J. Y., Jeon, S. M., Park, M. S., & Kimb, S. H. (2011). genotypic characterization of Vibrio vulnificus clinical isolates in Korea. Osong Public Health and Research Perspectives, 2(1), 8–14. https://doi.org/10.1016/j.phrp.2011.04.008
Jones, M. K., & Oliver, J. D. (2009). Vibrio vulnificus: Disease and pathogenesis. Infection and Immunity, 77(5), 1723–1733. https://doi.org/10.1128/IAI.01046-08
Kim WB, Lee BC, Choi SH (2012) Vibrio vulnificus AphB is involved in interleukin-8 production via an NF-kappaB-dependent pathway in human intestinal epithelial cells. Biochem Biophys Res Commun 417(4):1265–1270. https://doi.org/10.1016/j.bbrc.2011.12.122
Koton, Y., Gordon, M., Chalifa-Caspi, V., and Bisharat, N. (2015) Comparative genomic analysis of clinical and environmental Vibrio vulnificus isolates revealed biotype 3 evolutionary relationships. Front Microbiol 5: 1–10.
Lee SJ, Jung YH, Oh SY, Song EJ, Choi SH, Han HJ (2015) Vibrio vulnificus VvhA induces NF-kappaB-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells. Cell Death Dis 6:1655. https://doi.org/10.1038/cddis.2015.19
Lee NY, Lee HY, Lee KH, Han SH, Park SJ (2011) Vibrio vulnificus IlpA induces MAPK-mediated cytokine production via TLR1/2
activation in THP-1 cells, a human monocytic cell line. Mol Immunol 49(1–2):143–154.
Leng, F., Lin, S., Wu, W., Zhang, J., Song, J., & Zhong, M. (2019). Epidemiology, pathogenetic mechanism, clinical characteristics, and treatment of Vibrio vulnificus infection: a case report and literature review. European Journal of Clinical Microbiology & Infectious Diseases, 38, 1999-2004.
Liu M, Crosa JH (2012) The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections. MicrobiologyOpen 1(4):502–513. https://doi.org/10.1002/mbo3.48
Matsuoka, Y., Nakayama, Y., Yamada, T., Nakagawachi, A., Matsumoto, K., Nakamura, K., … Sakaguchi, Y. (2013). Accurate diagnosis and treatment of Vibrio vulnificus infection: A retrospective study of 12 cases. Brazilian Journal of Infectious Diseases, 17(1), 7–12. https://doi.org/10.1016/j.bjid.2012.07.017
Nakashima, Y., Oho, M., Kusaba, K., Nagasawa, Z., Komatsu, O., Manome, I., … Nakashima, M. (2007). A Chromogenic Substrate Culture Plate for Early Identification of Vibrio vulnificus and Isolation of Other Marine Vibrios, 37(4), 330–334.
Novoslavskij, A., Terentjeva, M., Eizenberga, I., Valciņa, O., Bartkevičs, V., & Bērziņš, A. (2016). Major foodborne pathogens in fish and fish products: a review. Annals of Microbiology, 66(1), 1–15. https://doi.org/10.1007/s13213-015-1102-5
Oliver, J. D., & Jones, J. L. (2015). Chapter 66 – Vibrio parahaemolyticus and Vibrio vulnificus. In Molecular Medical Microbiology (pp. 1169–1186). https://doi.org/10.1016/B978-0-12-397169-2.00066-4
Oliver, J.D. (2015) The biology of Vibrio vulnificus. Microbiol Spectr 3: 1–10.
Pajuelo D, Hernandez-Cabanyero C, Sanjuan E, Lee CT, Silva-Hernandez FX, Hor LI, MacKenzie S, Amaro C (2016) Iron and Fur in the life cycle of the zoonotic pathogen Vibrio vulnificus. Environ Microbiol 18(11):4005–4022. https://doi.org/10.1111/1462-2920.13424
Phillips, K. E., & Satchell, K. J. F. (2017). Vibrio vulnificus : From Oyster Colonist to Human Pathogen, 1(C), 1–5. https://doi.org/10.1371/journal.ppat.1006053
Putri, N. F. A., Wardani, A. K., & Harsojo. (2015). Aplikasi
teknologi iradiasi Gamma dan penyimpanan beku sebagai upaya penurunan bakteri patogen pada Seafood : kajian pustaka. Jurnal Pangan Dan Agroindustri, 3(2), 345–352.
Raszl, S. M., Froelich, B. A., Vieira, C. R. W., Blackwood, A. D., & Noble, R. T. (2016). Vibrio parahaemolyticus and Vibrio vulnificus in South America: water, seafood and human infections. Journal of Applied Microbiology, 121(5), 1201–1222. https://doi.org/10.1111/jam.13246
Roig, F.J., González-Candelas, F., Sanjuán, E., Fouz, B., Feil, E.J., Llorens, C., et al. (2018) Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy. Front Microbiol 8: 1–13.
Shapiro RL, Altekruse S, Hutwagner L, Bishop R, Hammond R, Wilson S, Ray B, Thompson S, Tauxe RV, Griffin PM (1998) The role of Gulf Coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States, 1988-1996. Vibrio Working Group. J Infect Dis 178(3):752–759
Song EJ, Lee SJ, Lim HS, Kim JS, Jang KK, Choi SH, Han HJ (2016) Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway. Sci Rep 6:27080. https://doi.org/10.1038/srep27080
Yu, W., Shen, X., Pan, H., Xiao, T., Shen, P., & Xiao, Y. (2017). Clinical features and treatment of patients with Vibrio vulnificus infection. International Journal of Infectious Diseases, 59, 1–6. https://doi.org/10.1016/j.ijid.2017.03.017
Published
2023-12-11
How to Cite
Sanam, M., Gelolodo, M., Tangkonda, E., & Loe, F. (2023). Tinjauan Vibrio Vulnificus sebagai Ancaman Emerging Foodborne Disease pada Makanan Laut Segar. JURNAL KAJIAN VETERINER, 11(2), 149-165. https://doi.org/10.35508/jkv.v11i2.12259
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