STUDI KOMPARASI RESPON ANTIBODI PASCA VAKSINASI CLASSICAL SWINE FEVER PADA BABI LANDRACE DAN BABI LOKAL TIMOR DI KABUPATEN KUPANG, NUSA TENGGARA TIMUR
A Comparative Study of Antibody Responses after Classical Swine Fever Vaccination in Landrace Pigs and Local Timor Pigs in Kupang Regency, East Nusa Tenggara
-
Ledy Chehfzy Salestin(1)
Fakultas Kedokteran Hewan Universitas Nusa Cendana
-
Maria Aega Gelolodo(2*)
Mahasiswa Program Pascasarjana, Fakultas Kedokteran Hewan, Universitas Airlangga, Surabaya, Jawa Timur
https://orcid.org/0000-0002-8912-5779
-
Elisabet Tangkonda(3)
Laboratorium Ilmu Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran Hewan Universitas Nusa Cendana
-
Maxs U. E. Sanam(4)
Laboratorium Ilmu Penyakit Hewan dan Kesehatan Masyarakat Veteriner, Fakultas Kedokteran Hewan Universitas Nusa Cendana
-
Feny A. L. Bili(5)
Dinas Peternakan Provinsi Nusa Tenggara Timur
(*) Corresponding Author
Keywords:
Antibody, Classical Swine Fever, Kupang, Pig, Vaccination
Abstract
Classical Swine Fever (CSF) is an important infectious disease caused by the CSF virus, which belongs to the Pestivirus genus from the family Flaviviridae. This disease has a high fatality rate in swine. Stamping out the disease and vaccinations aimed at forming and strengthening antibodies against CSF are proven to be effective ways of disease control and prevention. Several factors, including age, immune status, health status, nutrition, and the environment, are believed to influence the success of the immunization program. Furthermore, it is assumed that different pig breeds may have impacts on vaccination success. This study aimed to compare antibody responses after CSF vaccination in two different pig breeds, Landrace and local Timor pigs. A total of 26 pigs (13 pigs for each group) was occupied in this study. All of the pigs used in this study had never been vaccinated against CSF. Antibody titers were quantified using an ELISA test, then the data were compared using an independent t-test to assess the difference of antibody responses between Landrace and local Timor pigs. Finally, the study found no significant difference in antibody response between Landrace and local Timor pigs, with a significant value of 0.07 (P > 0.05). Therefore, it is feasible to conclude that breed does not influence antibody response following CSF vaccination.
Downloads
Download data is not yet available.
References
Blacksell, S. D., Khounsy, S., Van Aken, D., Gleeson, L. J., & Westbury, H. A. (2006). Comparative susceptibility of indigenous and improved pig breeds to Classical swine fe-ver virus infection: practical and epidemiological implica-tions in a subsistence-based, developing country set-ting. Tropical animal health and production, 38(6), 467-474.
Boklund, A., Toft, N., Alban, N., Ut-tenthal, A. 2009, Comparing the Epidemiological and Eco-nomic Effects of Control Strategies Against Classical Swine Fever in Denmark. Preventive Veterinary Medi-cine. Vol. 90:180–193.
Bulu, P.M., Robertson, I., Geong, M. 2015, Impacts of Pig Man-agement and Husbandry Farmers Towards Classical Swine Fever Transmission in West Timor Indonesia. Jurnal Veteriner, Vol. 16 (1).
Coronado, L., C. L. Perera, L. Rios, M. T. Frías, and L. J. Pérez. 2021. A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions. Vaccines 9(2):154.
Depner, K. R., Müller, A., Gruber, A., Rodriguez, A., Bickhardt, K., Liess, B. 1997, Classical Swine Fever in Wild Boar (Sus scrofa)–Experimental Infections and Viral Persistence. Vol.140:506–507.
Graham, S. P., H. E. Everett, F. J. Haines, H. L. Johns, O. A. Sosan, F. J. Salguero, D. J. Clifford, F. Steinbach, T. W. Drew, and H. R. Crooke. 2012. Challenge of pigs with classical swine fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. PloS one 7(1):e29310.
Hartatik, T., B. D. P. Soewandi, S. D. Volkandari, A. C. Tabun, S. Sumadi, and W. Widodo. 2016. Short Communication: Genetic identification of local pigs, and imported pigs Duroc) based on cytochrome b sequence analysis. Biodiversitas Journal of Biological Diversity 17(1):270-274. doi: 10.13057/biodiv/d170138
Kaden, V., H. Steyer, J. Schnabel, and W. Bruer. 2005. Classical swine fever (CSF) in wild boar: the role of the transplacental infection in the perpetuation of CSF. Journal of Veterinary Medicine, Series B 52(4):161-164.
Leslie, E. E. C. 2012. Pig Movements Across Eastern Indonesia and Associated Risk of Classical Swine Fever Transmission. Australian Centre for International Agricultural Research. Australia
Leslie, E. E., Geong, M., Abdurrahman, M., Ward, M. P., & Toribio, J.-A. L. (2015). A Description of Smallholder Pig Production Systems in Eastern Indonesia. Preventive veterinary medicine, Vol 118(4):319-327.
Moennig, V. 2000. Introduction to classical swine fever: virus, disease and control policy. Veterinary microbiology 73(2-3):93-102.
Moennig, V., Floegel-Niesmann, G., & Greiser-Wilke, I. 2003, Clinical Signs and Epidemiology of Classical Swine Fever: A Review of New Knowledge. The Veterinary Journal, Vol. 165(1):11-20.
OIE. 2014. Classical Swine Fever Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2015.
Petrov, A., Blohm, U., Beer, M., , Pietschmann, J., dan Blome, S. 2014, Comparative Analyses of Host Responses upon Infection with Moderately Virulent Classical Swine Fever Virus in Domestic Pigs and Wild Boar. Virology Journal , Vol.11:134.
Ratundima, E. M., Suartha, I. N., Mahardhika, I. G. N. K. 2012. Deteksi Antibodi terhadap Virus Classical Swine Fever dengan Teknik Enzyme-Linked Immunosorbent Assay. Indonesia Medicus Veterinus, Vol.1(2):217–227
Rios, L., and L. J. Pérez. 2018. Commentary: Genetic evolution of classical swine fever virus under immune environments conditioned by genotype 1-based modified live virus vaccine. Frontiers in veterinary science 5:55.
Rothschild MF, Ruvinsky A, Larson G, Gongora J, Cucchi T, Dob-ney K, Andersson L, Plastow G, Nicholas FW, Moran C, et al. 2011. The genetics of the pig. 2nd ed. Rothschild MF, Ruvinsky A, editors. London: CAB International.
Sawford, K., Geong, M., Bulu, P. M., Drayton, E., Mahardika, G. N., Leslie, E. E., ... & Toribio, J. A. L. (2015). An investigation of classical swine fever virus seroprevalence and risk factors in pigs in East Nusa Tenggara, eastern Indonesia. Preventive veterinary medicine, 119(3-4), 190-202.
Soewandi, B. D. P., and C. Talib. 2015. Development of Local Pig in Indonesia. Indonesian Bulletin of Animal and Veterinary Sciences 25(1)doi: 10.14334/wartazoa.v25i1.1127
Suradhat, S., and S. Damrongwatanapokin. 2003. The influence of maternal immunity on the efficacy of a classical swine fever vaccine against classical swine fever virus, genogroup 2.2, infection. Veterinary microbiology 92(1-2):187-194.
Suradhat, S., M. Intrakamhaeng, and S. Damrongwatanapokin. 2001. The correlation of virus-specific interferon-gamma production and protection against classical swine fever virus infection. Veterinary immunology and immunopathology 83(3-4):177-189.
Tarradas, J., J. Argilaguet, R. Rosell, M. Nofrarias, E. Crisci, L. Córdoba, E. Pérez-Martín, I. Díaz, F. Rodríguez, and M. Domingo. 2010. Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical
swine fever virus infection in domestic pigs. Veterinary microbiology 142(1-2):51-58.
Terpstra, C., R. Woortmeyer, and S. Barteling. 1990. Development and properties of a cell culture produced vaccine for hog cholera based on the Chinese strain. DTW. Deutsche tierarztliche Wochenschrift 97(2):77-79.
Xia, H., N. Wahlberg, H.-J. Qiu, F. Widén, S. Belák, and L. Liu. 2011. Lack of phylogenetic evidence that the Shimen strain is the parental strain of the lapinized Chinese strain (C-strain) vaccine against classical swine fever. Archives of virology 156(6):1041-1044.
Xu, L., X.-Z. Fan, Q.-Z. Zhao, Z.-X. Zhang, K. Chen, Y.-b. Ning, Q.-Y. Zhang, X.-Q. Zou, Y.-Y. Zhu, and C. Li. 2018. Effects of vaccination with the C-strain vaccine on immune cells and cytokines of pigs against classical swine fever virus. Viral immunology 31(1):34-39.
Yoo, S., T. Kwon, K. Kang, H. Kim, S. Kang, J. Richt, and Y. Lyoo. 2018. Genetic evolution of classical swine fever virus under immune environments conditioned by genotype 1‐based modified live virus vaccine. Transboundary and emerging diseases 65(3):735-745.
Boklund, A., Toft, N., Alban, N., Ut-tenthal, A. 2009, Comparing the Epidemiological and Eco-nomic Effects of Control Strategies Against Classical Swine Fever in Denmark. Preventive Veterinary Medi-cine. Vol. 90:180–193.
Bulu, P.M., Robertson, I., Geong, M. 2015, Impacts of Pig Man-agement and Husbandry Farmers Towards Classical Swine Fever Transmission in West Timor Indonesia. Jurnal Veteriner, Vol. 16 (1).
Coronado, L., C. L. Perera, L. Rios, M. T. Frías, and L. J. Pérez. 2021. A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions. Vaccines 9(2):154.
Depner, K. R., Müller, A., Gruber, A., Rodriguez, A., Bickhardt, K., Liess, B. 1997, Classical Swine Fever in Wild Boar (Sus scrofa)–Experimental Infections and Viral Persistence. Vol.140:506–507.
Graham, S. P., H. E. Everett, F. J. Haines, H. L. Johns, O. A. Sosan, F. J. Salguero, D. J. Clifford, F. Steinbach, T. W. Drew, and H. R. Crooke. 2012. Challenge of pigs with classical swine fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. PloS one 7(1):e29310.
Hartatik, T., B. D. P. Soewandi, S. D. Volkandari, A. C. Tabun, S. Sumadi, and W. Widodo. 2016. Short Communication: Genetic identification of local pigs, and imported pigs Duroc) based on cytochrome b sequence analysis. Biodiversitas Journal of Biological Diversity 17(1):270-274. doi: 10.13057/biodiv/d170138
Kaden, V., H. Steyer, J. Schnabel, and W. Bruer. 2005. Classical swine fever (CSF) in wild boar: the role of the transplacental infection in the perpetuation of CSF. Journal of Veterinary Medicine, Series B 52(4):161-164.
Leslie, E. E. C. 2012. Pig Movements Across Eastern Indonesia and Associated Risk of Classical Swine Fever Transmission. Australian Centre for International Agricultural Research. Australia
Leslie, E. E., Geong, M., Abdurrahman, M., Ward, M. P., & Toribio, J.-A. L. (2015). A Description of Smallholder Pig Production Systems in Eastern Indonesia. Preventive veterinary medicine, Vol 118(4):319-327.
Moennig, V. 2000. Introduction to classical swine fever: virus, disease and control policy. Veterinary microbiology 73(2-3):93-102.
Moennig, V., Floegel-Niesmann, G., & Greiser-Wilke, I. 2003, Clinical Signs and Epidemiology of Classical Swine Fever: A Review of New Knowledge. The Veterinary Journal, Vol. 165(1):11-20.
OIE. 2014. Classical Swine Fever Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2015.
Petrov, A., Blohm, U., Beer, M., , Pietschmann, J., dan Blome, S. 2014, Comparative Analyses of Host Responses upon Infection with Moderately Virulent Classical Swine Fever Virus in Domestic Pigs and Wild Boar. Virology Journal , Vol.11:134.
Ratundima, E. M., Suartha, I. N., Mahardhika, I. G. N. K. 2012. Deteksi Antibodi terhadap Virus Classical Swine Fever dengan Teknik Enzyme-Linked Immunosorbent Assay. Indonesia Medicus Veterinus, Vol.1(2):217–227
Rios, L., and L. J. Pérez. 2018. Commentary: Genetic evolution of classical swine fever virus under immune environments conditioned by genotype 1-based modified live virus vaccine. Frontiers in veterinary science 5:55.
Rothschild MF, Ruvinsky A, Larson G, Gongora J, Cucchi T, Dob-ney K, Andersson L, Plastow G, Nicholas FW, Moran C, et al. 2011. The genetics of the pig. 2nd ed. Rothschild MF, Ruvinsky A, editors. London: CAB International.
Sawford, K., Geong, M., Bulu, P. M., Drayton, E., Mahardika, G. N., Leslie, E. E., ... & Toribio, J. A. L. (2015). An investigation of classical swine fever virus seroprevalence and risk factors in pigs in East Nusa Tenggara, eastern Indonesia. Preventive veterinary medicine, 119(3-4), 190-202.
Soewandi, B. D. P., and C. Talib. 2015. Development of Local Pig in Indonesia. Indonesian Bulletin of Animal and Veterinary Sciences 25(1)doi: 10.14334/wartazoa.v25i1.1127
Suradhat, S., and S. Damrongwatanapokin. 2003. The influence of maternal immunity on the efficacy of a classical swine fever vaccine against classical swine fever virus, genogroup 2.2, infection. Veterinary microbiology 92(1-2):187-194.
Suradhat, S., M. Intrakamhaeng, and S. Damrongwatanapokin. 2001. The correlation of virus-specific interferon-gamma production and protection against classical swine fever virus infection. Veterinary immunology and immunopathology 83(3-4):177-189.
Tarradas, J., J. Argilaguet, R. Rosell, M. Nofrarias, E. Crisci, L. Córdoba, E. Pérez-Martín, I. Díaz, F. Rodríguez, and M. Domingo. 2010. Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical
swine fever virus infection in domestic pigs. Veterinary microbiology 142(1-2):51-58.
Terpstra, C., R. Woortmeyer, and S. Barteling. 1990. Development and properties of a cell culture produced vaccine for hog cholera based on the Chinese strain. DTW. Deutsche tierarztliche Wochenschrift 97(2):77-79.
Xia, H., N. Wahlberg, H.-J. Qiu, F. Widén, S. Belák, and L. Liu. 2011. Lack of phylogenetic evidence that the Shimen strain is the parental strain of the lapinized Chinese strain (C-strain) vaccine against classical swine fever. Archives of virology 156(6):1041-1044.
Xu, L., X.-Z. Fan, Q.-Z. Zhao, Z.-X. Zhang, K. Chen, Y.-b. Ning, Q.-Y. Zhang, X.-Q. Zou, Y.-Y. Zhu, and C. Li. 2018. Effects of vaccination with the C-strain vaccine on immune cells and cytokines of pigs against classical swine fever virus. Viral immunology 31(1):34-39.
Yoo, S., T. Kwon, K. Kang, H. Kim, S. Kang, J. Richt, and Y. Lyoo. 2018. Genetic evolution of classical swine fever virus under immune environments conditioned by genotype 1‐based modified live virus vaccine. Transboundary and emerging diseases 65(3):735-745.
Published
2021-12-09
How to Cite
Salestin, L., Gelolodo, M., Tangkonda, E., Sanam, M., & Bili, F. (2021). STUDI KOMPARASI RESPON ANTIBODI PASCA VAKSINASI CLASSICAL SWINE FEVER PADA BABI LANDRACE DAN BABI LOKAL TIMOR DI KABUPATEN KUPANG, NUSA TENGGARA TIMUR. JURNAL KAJIAN VETERINER, 9(3), 184-193. https://doi.org/10.35508/jkv.v9i3.4956
Section
Articles
Copyright (c) 2021 JURNAL KAJIAN VETERINER
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
.png)
