AKTIVITAS SITOTOKSISITAS EKSTRAK ETANOL KULIT BUAH JAMBU MENTE (Anacardium occidentale L.) TERHADAP SEL MIELOMA
Abstract
The activity of cashew nut shell liquid as one of the anticancer agent, especially at myeloma cell has been carried out. The main purpose of this research is to determine the cytotoxicity of cashew nut shell ethanol extract to myeloma cell. Myeloma cells were divided into treatment groups, control cell group, positive control
group, medium control group and cosolven control, each of 3 repeats. The concentration of cashew nut shell ethanol extract which is used 12.5, 25, 50, 100, 200, 400 μg/mL and doxorubicin 3.125, 6. 25, 12.5, 25, 50, 100 μg/mL. Cytotoxicity test use direct counting method. The result of this research showed that LC50 = 40.514 μg/mL at cytotokxicity test with direct counting method. The result of this research could be concluded that cashew nut shell (Anacardium occidentale L.) ethanol extract has toxic activity to myeloma cells.