The Pengaruh Pemberian Ivermectin Terhadap Perubahan Sel Darah Putih Pada Kambing Kacang Yang Dipelihara Secara Intensif
The Effect of Ivermectin Administration on Changes in White Blood Cells in Intensively Raised Goats
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Christvando Rendi Leba Tagu Bore(1*)
Student Faculty of Medicine and Veterinary Medicine, Veterinary Medicine Study Program, Nusa Cendana University, Kupang
(*) Corresponding Author
Keywords:
endoparasites, gastrointestinal, Ivermectin, pea goats, white blood cells
Abstract
This study aims to determine the effect of Ivermectin on the differential picture of white blood cells of pea goats before and after endoparasite treatment in a semi-intensive rearing system. The study used 11 pea goats placed in individual pens with a platform and fed with KGP 709 concentrate. Ivermectin was given at a dose of 2.5 ml/head. Tools used included a microscope, EDTA tube, syringe, centrifuge, glass slide and cover, and dropper pipette. Parameters observed were white blood cell profile and gastrointestinal parasite infection based on faecal examination. Data were analysed using One Way ANOVA and presented descriptively. Faecal examination results showed gastrointestinal parasite infection with dominant species Haemonchus contortus (5, TPG 1-33), Trichuris spp. (3, maximum TPG 11), Strongyloides spp. (4, maximum TPG 61), Eimeria spp. (6, mild to severe infection), and Cystotoma spp. (5). Ivermectin administration significantly affected the percentage of neutrophils, eosinophils and basophils (p0.05), indicating that Ivermectin did not affect all white blood cell types equally. In conclusion, this study showed that pea goats were infected with gastrointestinal parasites with a predominance of Haemonchus contortus, Trichuris spp., Strongyloides spp., Eimeria spp. and Cystotoma spp. Ivermectin administration was shown to affect neutrophils, eosinophils and basophils, reflecting the immune
response to parasitic infection.
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Chaccour, C., Casellas, A., Blanco-Di Matteo, A., Pineda, I., Fernandez-Montero, A., Ruiz-Castillo, P., Richardson, M.-A., Rodríguez-Mateos, M., Jordán-Iborra, C., Brew, J., Carmona-Torre, F., Giráldez, M., Laso, E., Gabaldón-Figueira, J. C., Dobaño, C., Moncunill, G., Yuste, J. R., Del Pozo, J. L., Rabinovich, N. R., … Fernández-Alonso, M. (2021). The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial. EClinicalMedicine, 32, 100720. https://doi.org/10.1016/j.eclinm.2020.100720
Crump, A., & Omura, S. (2011). Ivermectin, “Wonder drug” from Japan: The human use perspective. Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 87(2), 13–28. https://doi.org/10.2183/pjab.87.13
Dalle, N. S., Luju, M. T., Utama, W. G., Achmadi, P. C., Gultom, R., & Jeramat, A. A. (2023). Edukasi Manajemen Pemeliharaan Ternak Kambing Bagi Peternak Di Nusa Tenggara Timur. JMM (Jurnal Masyarakat Mandiri), 7(4), 3635–3636. https://doi.org/10.31764/jmm.v7i4.16186
Datta, F. U., Tinenti, T., Detha, A. I., Foeh, N. D. F. K., & Ndaong, N. A. (2019). Deskripsi MOrfologis Nematoda Saluran Pencernaan Kambing Kacang (Capra hircus aegagrus) di Kota Kupang Nusa Tenggara Timur. Prosiding Seminar Nasional VII Fakultas Kedokteran Hewan Universitas Nusa Cendana, 17, 46–57.
Gadahi, J., Arshed, M., Ali, Q., & Syed, I. (2009). Prevalence of Gastrointestinal Parasites of Sheep and Goat in and around Rawalpindi and Islamabad, Pakistan. Veterinary World, 2.
Gaudin, E., Simon, M., Quijada, J., Schelcher, F., Sutra, J.-F., Lespine, A., & Hoste, H. (2016). Efficacy of sainfoin (Onobrychis viciifolia) pellets against multi resistant Haemonchus contortus and interaction with oral ivermectin: Implications for on-farm control. Veterinary Parasitology, 227, 122–129. https://doi.org/https://doi.org/10.1016/j.vetpar.2016.08.002
González Canga, A., Sahagún Prieto, A. M., Diez Liébana, M. J., Fernández Martínez, N., Sierra Vega, M., & García Vieitez, J. J. (2008). The pharmacokinetics and interactions of ivermectin in humans--a mini-review. The AAPS Journal, 10(1), 42–46. https://doi.org/10.1208/s12248-007-9000-9
Khalafalla, R. E., Elseify, M. A., & Elbahy, N. M. (2011). Seasonal prevalence of gastrointestinal nematode parasites of sheep in Northern region of Nile Delta, Egypt. Parasitology Research, 108(2), 337–340. https://doi.org/10.1007/s00436-010-2066-9
Laing, R., Gillan, V., & Devaney, E. (2017). Ivermectin – Old Drug, New Tricks? Trends in Parasitology, 33(6), 463–472. https://doi.org/10.1016/j.pt.2017.02.004
Muaharramah, V., Siska, I., & Anggrayni Lia, Y. (2020). Penerapan Aspek Teknis Pemeliharaan Ternak Kambing di Kecamatan Kuantan Tengah Kabupaten Kuantan Singingi. Jurnal of Animal Center, 2(1), 1–11. https://doi.org/10.36378/jac.v2i1.1354
Nurdin, S., Risna, Y. K., & Suryani. (2023). Identification Of Endoparasite Prevalence In Goats In Sawang District, Aceh Utara District. Jurnal Ilmiah Peternakan, 12(1), 17–23. https://doi.org/10.51179/jip.v12i1.2692
Omura, S., & Crump, A. (2014). Ivermectin: panacea for resource-poor communities? Trends in Parasitology, 30(9), 445–455. https://doi.org/10.1016/j.pt.2014.07.005
Ōmura, S., & Crump, A. (2014). Ivermectin: panacea for resource-poor communities? Trends in Parasitology, 30(9), 445–455. https://doi.org/10.1016/j.pt.2014.07.005
Raza, A., Qamar, A. G., Hayat, K., Ashraf, S., & Williams, A. R. (2019). Anthelmintic resistance and novel control options in equine gastrointestinal nematodes. Parasitology, 146(4), 425–437. https://doi.org/10.1017/S0031182018001786
Satriawan, L., Sandiah, N., & Aka, R. (2023). Sistem Pemeliharaan Kambing Kacang Di Kecamatan Binongko Kabupaten Wakatobi. Jurnal Ilmiah Peternakan Halu Oleo, 5(4), 284–289. https://doi.org/10.56625/jipho.v5i4.41853
Tang, M., Hu, X., Wang, Y., Yao, X., Zhang, W., Yu, C., Cheng, F., Li, J., & Fang, Q. (2021). Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacological Research, 163(105207), 1–11. https://doi.org/10.1016/j.phrs.2020.105207
Tanjung, M., & Thahira, D. (2021). Endoparasites of cattle raised under intensive and semi-intensive system at Klumpang Kebon Village, North Sumatra. IOP Conference Series: Earth and Environmental Science, 713(1), 1–6. https://doi.org/10.1088/1755-1315/713/1/012057
Weiss, D. J., Wardrop, K. J., & Schalm, O. W. (Oscar W. (2010). Schalm’s veterinary hematology. In Veterinary hematology. (6th ed. /). Wiley-Blackwell.
Wen, C., Mai, C., Wang, B., Li, J., Sun, C., & Yang, N. (2020). Detrimental effects of excessive fatty acid secretion on female sperm storage in chickens. Journal of Animal Science and Biotechnology, 11(1), 26. https://doi.org/10.1186/s40104-020-0432-8
Winarso, A. (2018). Infeksi parasit gastrointestinal pada kambing di Kupang. ARSHI Veterinary Letters, 2(2), 25–26. https://doi.org/10.29244/avl.2.2.25-26
Wirawan, I. G. K. O., & Semang, A. (2022). Perubahan Eksterior Kambing Kacang (Capra hircus) Terinfeksi Haemonchus contortus. Prosiding Seminar Nasional Hasil-Hasil Penelitian, 5(1), 42–46. https://ejurnal.politanikoe.ac.id/index.php/psnp/article/view/114
Worku, M., Franco, R., & Baldwin, K. (2009). Efficacy of garlic as an anthelmintic in adult Boer goats. Archives of Biological Sciences, 61(1), 135–140. https://doi.org/10.2298/ABS0901135W
Published
2025-12-04
How to Cite
Leba Tagu Bore, C. (2025). The Pengaruh Pemberian Ivermectin Terhadap Perubahan Sel Darah Putih Pada Kambing Kacang Yang Dipelihara Secara Intensif. JURNAL KAJIAN VETERINER, 13(2), 116-125. https://doi.org/10.35508/jkv.v13i2.22628
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