Studi Literatur Potensi Antivirus Laktoferin Susu Kuda Terhadap Virus Japenese Encephalitis
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Diana Rambu Naha Ana Awa(1*)
Diana Rambu Naha Ana Awa
-
Annytha I.R Detha(2)
-
Agus Saputra(3)
(*) Corresponding Author
Keywords:
Lactoferrin, Virus Japanese Encephalitis, Horse Milk, Antivirus
Abstract
Lactoferrin is a type of protein found in many fluid secretions such as saliva, tears, blood, neutrophil and milk. Subcutaneus or oral administration of lactoferrin can inhibit the growth of tumor implants and have a preventive effect on metastases. According to lactoferrin, viruses carried by mosquitoes, such as the Japanese encephalitis, can be inhibited. This virus causes Japanese encephalitis which is zoonotic and transmitted by the bite of the Culex tritaeniorhynchus as the main vector. Therefore, it is interesting to conduct an in-depth study related to the lactoferrin antiviral potential on Japanese encephalitis virus. The aim of this literature study is to identify the mechanism of the lactoferrin antiviral ability of horse milk and analyze the lactoferrin potential of horse milk on Japanese encephalitis virus. In addition, it was obtained from searches and collections of various sources of reference using Mendeley and Google Scholar applications with a total of 52 references. After being analyzed and assessed, the mechanism of antiviral ability lactoferrin mediated by the N-lactoferrin lobe and various antiviral mechanisms, such as attachment of the virus to the host cell membrane and adsorption of the virus to the host cell.
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References
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Berlutti F, Pantanella F, Natalizi T, Frioni A, Paesano R, Polimeni A, & Valenti P. 2011. Antiviral properties of lactoferrin\-a natural immunity molecule. Molecules, 16 (8): 6992-7018.
Bokare AD & Choi W. 2014. Review of iron-free Fenton-like system for activating H2O2 in advanced oxidation process. Journal of Hazardous Materials, 275: 121-135.
Bokkhim H, Bansal N, Grondahl L & Bhandari B. 2013. Physico-chemical properties of different forms of bovine lactoferrin. Food Chemistry, 141 (3): 3007-3013.
Chekhun VF, Storchai DM, Todor IN, Borikun TV, & Lukianova NY. 2018. Antitumor and genotoxic effects of lactoferrin in walker-256 tumor-bearing rats. Exp Oncol, 40 (3): 200–204.
Chien Y, Chen W, Hsu W, & Chiou S. 2008. Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein. Virology, 379 (1): 143–151.
Cozma A, Andrei S, Miere D, Filip L, & Loghin F. 2011. Proteins Profile in Milk from Three Species of Ruminants. Notulae Scientia Biologicae, 3 (1): 26-29.
Detha AIR. 2016. Buku Ajar Japanese Encephalitis, Kupang: UNDANA PRESS.
Detha A, Wuri DA, & Santhia K. 2015. Seroprevalence of Japanese encephalitis virus using competitive enzyme linked immunosorbent assay (C-ELISA) in pigs in East Sumba, Indonesia. Journal of Advanced Veterinary and Animal Research, 2 (4): 481-48.
Detha AIRS, Mirnawati L, Handri dan Frans UD. 2014. Komposisi Kimiawi dan Fraksinasi Protein Susu Kuda Sumba. Jurnal Veteriner, 15 (4): 506-514.
Duarte DC, Nicolau A, Teixeira JA, & Rodrigues LR. 2011. The effect of bovine milk lactoferrin on human breast cancer cell lines. Journal of Dairy Science, 94 (1): 66–76.
Elena VR. 2015. Bovine Lactoferrin Inhibits Toscana Virus Infection by Binding to Heparan Sulphate.Viruses, 7(2): 480–495.
Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans R. W, Roseanu A, & Branza-Nichita N. 2013. Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide. Journal of Medical Virology, 85 (5): 780-788.
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Inglingstad RA, Devold TG, Eriksen EK, Holm H, Jacobsen M, Lailand, KH et al., 2010. Comparison of the digestion of caseins and whey proteins in equine, bovine, caprine ang human milk by human gastrointestinal enzyme. Dairy Science & Techonology, 9 (5): 549-563.
Kumara MBAQ, Adi AAAM, & Mahardika IGNK. 2013. Deteksi Antibodi terhadap Virus Japanese Encephalitis pada Ternak Babi Di Wilayah Jembrana dan Klungkung. Indonesia Medicus Veterinus, 2: 76-84.
Kusumaningtyas E. 2013. Peran peptida susu sebagai antimikroba untuk meningkatkan kesehatan. Wartazoa, 23 (2): 63–75.
Laili FN, Setiowati E & Iravati S. 2014. Susu kuda sumbawa khas Indonesia: Bahan antibakteri jerawat (staphyloccus epidermis). Tra Med Journal, 19 (2): 79-87.
Lestari D & Soesilo VV. 2017. Aktivitas antibakteri peptida kasein susu kambing hidrolisis oleh papain terhadap pseudomonas aeruginosa. Jurnal Ilmu Pangan Dan Hasil Pertanian, 1 (2): 81–92.
Liao Y, Jiang R & Lonnerdal B. 2012. Biochemical and moleculer impacts of lactoferrin on small intestinal growth and development during early life. Biochemistry and Cell Biology, 90 (3): 476-484.
Li Q & Zhao Z, 2017. Formation of lactoferrin/sodium caseinate complexes and their adsorpsion behavior at the air/water interface. Food Chemistry, 232: 697-871.
Lizzi AR, Carnicelli V, Clarkson MM, Nazzicone C, Segatore B, Celenza G et al., 2016. Bovine lactoferrin and its trypic peptides: Antibacterial activity against different species. Applied Biochemistry and Microbiology, 52 (4): 435-440.
Lonnerdal B. 2016. Bioactive proteins in human milk: health, nutritional and implications for infant formulas. The Journal of Pediatrics, 173: 54-59.
Ng TB, Chi R, Cheung F, Wong JH, Wang Y, Tsz D, Ip M, Chi D, Wan C & Xia J. 2015a. Antiviral activities of whey proteins. Appl Microbial Biotechnol, 99 (17): 6997–7008.
McGregor R & Poppit SD. 2013. Milk protein for improved metabolic health: a review of the evedence. Nutritional Metabolic, 10 (46) :1-13.
Oda H, Wakabayashi H, Yamauchi K & Abe F. 2014. Lactoferrin and bifidobacteria. BioMetals, 27 (5): 915-922.
Ostan NK, Yu RH, Ng D, Lai CCL, Pogoutse AK, Sarpe V et al., 2017. Lactoferrin binding protein B-a bi-funcional bacterial receptor protein. PLoS Pathogens, 13 (3): 100-224.
Ozer BH & Kirmaci NA. 2010. Functional milks and dairy beverages. Journal of Dairy Techonology, 63 (1): 1-15.
Paesano R, Berlutti F, Pietropaoli M, Pantanella F, Pacifici E, Goolsbee W & Valenti P. 2010. Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. Biometals,23 (3): 411-417.
Phaniendra A, Jestadi DB & Periyasamy L. 2015. Free radicals: properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry, 30 (1): 11-26.
Pietrantoni A, Dofrelli E, Tinari A, Ammendolia MG, Puzelli S, Fabiani C, Donatelli I, & Superti F. 2010. Bovine lactoferrin inhibits Influenza A virus induced programmed cell death in vitro. BioMetals, 23(3): 465-75.
Rezk M, Kandil M, Dawood R, Shaheen AE & Allam A. 2015. Oral lactoferrin versus ferrous sulphate and ferrous fumerate for the treatment of iron deficiency anemia during pregnancy. Journal of Advanced Nutritional and Human Metabolism, 2012: 1-5.
Safitri MF & Swarastuti A. 2013. Kualitas Kefir Berdasarkan Konsentrasi Kefir Grain. Jurnal Aplikasi Teknologi Pangan, 2 (2): 87-92.
Shimojima K, Isidor B, Le Caignec C, Kondo A, Sakata S, Ohno K, & Yamamoto T. 2011. A new microdeletion syndrome of 5q31.3 characterized by severe developmental delays, distinctive facial features, and delayed myelination. American Journal of Medical Genetics, Part A, 155 (4): 732-736.
Sinha M, Kaushik S, Kaur P, Sharma S & Singh TP. 2013. Antimicrobial Lactoferrin Peptides : The Hidden Players in the Protective Function of a Multifunctional Protein. Internasional Journal of Peptides, 2013: 1-12.
Siqueiros-cendón T, Arévalo-gallegos S, Iglesias-figueroa BF & Abril I. 2014. Immunomodulatory effects of lactoferrin. Nature Publishing Group, 35 (5): 557–566.
Taha F, Mehrez MA, Sitohy M, Dawood AGIA, Hamid MMA, Kilany WH. 2010. Effectiveness of esterified whey proteins fractions against Egyptian lethal avian influenza A (H5N1). Virololy Journal, 7(1): 330-333.
Uniacke-Lowe T, Huppertz T & Fox PF. 2010. Equine milk proteins: Chemistry, structure and nutritional significance. In International Dairy Journal, 20 (9): 609-629.
Van der Strate BWA, Beljaars L, Molema G, Harmsen MC, Meijer DKF. 2001. Antiviral activities of lactoferrin. Antiviral Research, 52
Vogel HJ. 2012. Lactoferrin a birds eye view. Biochemistry and Biology, 90 (3): 233-244.
Wakabayashi H, Oda H, Yamauchi K & Abe F. 2014. Lactoferrin for prevention of common viral infections. Journal of Infection and Chemotherapy, 20 (11): 666–671.
Wang B, Timilsena YP, Blanch E & Adhikari B. 2017b. Characteristics of bovine lactoferrin powders produced though spray and freeze drying processes. International Journal of Biological Macromolecules, 95: 985-994.
Wang B, Timilsena YP, Blanch E & Adhikari B. 2017c. Drying and denaturation characteristics of three forms of bovine lactoferrin. Drying Technology, 5: 606-615.
Yamamoto H, Ura Y, Tanemura M, Koyama A, Takano S, Uematsu J et al. 2010.
Efek penghambatan laktoferin sapi pada manusia infeksi virus parainfluenza tipe 2. J. Ilmu Kesehatan, 54: 613-617.
Yamanaka A, Mulyatno KC, Susilowati H, Hendrianto E, Utsumi T, Amin M, Lusida MI, Soegijanto S & Konishi E. 2010. Prevalence of antibodies to japanese encephalitis virus among pigs in Bali and East Java, Indonesia. Japanese Journal of Infectious Diseases, 63 (1): 58-60.
Yasuhara-Bell J & Lu Y. 2010. Marine compounds and their antiviral activities. In Antiviral Research, 86 (3): 231-240.
Zhang L, Luan RS, Jiang F, Rui LP, Liu M, Li YX, Yin ZD & Luo HM. 2012. Epidemiological characteristics of Japanese encephalitis in Guizhou Province, China, 1971-2009. Biomedical and Environmental Sciences, 25 (3): 297-304.
Zheng B, Wang X, Liu Y, Li Y, Long S, Gu C, Ye J, Xie S & Cao S. 2019. Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I—NF-ĸB signaling pathway. Veterinary Microbiology, 238: 108-430.
Zheng Y, Li M, Wang H & Liang G. 2012. Japanese encephalitis and Japanese encephalitis virus in mainland China. In Reviews in Medical Virology, 22 (5): 301-322.
Ammendolina AG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, Guilio BD, 2012. Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. Pathog Glob Health, 106 (1): 12-19.
Baker HM, & Baker EN, 2012. A structural perspective on lactofferin function. Biochemistry and Cell Biology, 90 (3): 320-328.
Barbiroli A, Bonomi F, Capretti G, Iametti S, Manzoni M,Piergiovanni L, & Rollini M. 2012. Antimicrobial activity of lysozyme and lactoferrin incorporated in cellulose-based food packaging. Food Control, 26 (2): 387-392.
Berlutti F, Pantanella F, Natalizi T, Frioni A, Paesano R, Polimeni A, & Valenti P. 2011. Antiviral properties of lactoferrin\-a natural immunity molecule. Molecules, 16 (8): 6992-7018.
Bokare AD & Choi W. 2014. Review of iron-free Fenton-like system for activating H2O2 in advanced oxidation process. Journal of Hazardous Materials, 275: 121-135.
Bokkhim H, Bansal N, Grondahl L & Bhandari B. 2013. Physico-chemical properties of different forms of bovine lactoferrin. Food Chemistry, 141 (3): 3007-3013.
Chekhun VF, Storchai DM, Todor IN, Borikun TV, & Lukianova NY. 2018. Antitumor and genotoxic effects of lactoferrin in walker-256 tumor-bearing rats. Exp Oncol, 40 (3): 200–204.
Chien Y, Chen W, Hsu W, & Chiou S. 2008. Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein. Virology, 379 (1): 143–151.
Cozma A, Andrei S, Miere D, Filip L, & Loghin F. 2011. Proteins Profile in Milk from Three Species of Ruminants. Notulae Scientia Biologicae, 3 (1): 26-29.
Detha AIR. 2016. Buku Ajar Japanese Encephalitis, Kupang: UNDANA PRESS.
Detha A, Wuri DA, & Santhia K. 2015. Seroprevalence of Japanese encephalitis virus using competitive enzyme linked immunosorbent assay (C-ELISA) in pigs in East Sumba, Indonesia. Journal of Advanced Veterinary and Animal Research, 2 (4): 481-48.
Detha AIRS, Mirnawati L, Handri dan Frans UD. 2014. Komposisi Kimiawi dan Fraksinasi Protein Susu Kuda Sumba. Jurnal Veteriner, 15 (4): 506-514.
Duarte DC, Nicolau A, Teixeira JA, & Rodrigues LR. 2011. The effect of bovine milk lactoferrin on human breast cancer cell lines. Journal of Dairy Science, 94 (1): 66–76.
Elena VR. 2015. Bovine Lactoferrin Inhibits Toscana Virus Infection by Binding to Heparan Sulphate.Viruses, 7(2): 480–495.
Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans R. W, Roseanu A, & Branza-Nichita N. 2013. Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide. Journal of Medical Virology, 85 (5): 780-788.
Herlina N, Mustopa AZ, Surachma RS, Triratna L, Kartina G & Alfisyahrin WN. 2019. Aktivitas Antibakteri dan Antioksidan Peptida Susu Kambing Hasil Hidrolisis dengan Protease Lactobacillus plantarum S31 ( Antibacterial and Antioxidant Activity of Goat Milk Peptide Hydrolyzed with Protease of Lactobacillus plantarum S31 ). Jurnal Biologi Indonesia, 15 (1): 23–31.
Inglingstad RA, Devold TG, Eriksen EK, Holm H, Jacobsen M, Lailand, KH et al., 2010. Comparison of the digestion of caseins and whey proteins in equine, bovine, caprine ang human milk by human gastrointestinal enzyme. Dairy Science & Techonology, 9 (5): 549-563.
Kumara MBAQ, Adi AAAM, & Mahardika IGNK. 2013. Deteksi Antibodi terhadap Virus Japanese Encephalitis pada Ternak Babi Di Wilayah Jembrana dan Klungkung. Indonesia Medicus Veterinus, 2: 76-84.
Kusumaningtyas E. 2013. Peran peptida susu sebagai antimikroba untuk meningkatkan kesehatan. Wartazoa, 23 (2): 63–75.
Laili FN, Setiowati E & Iravati S. 2014. Susu kuda sumbawa khas Indonesia: Bahan antibakteri jerawat (staphyloccus epidermis). Tra Med Journal, 19 (2): 79-87.
Lestari D & Soesilo VV. 2017. Aktivitas antibakteri peptida kasein susu kambing hidrolisis oleh papain terhadap pseudomonas aeruginosa. Jurnal Ilmu Pangan Dan Hasil Pertanian, 1 (2): 81–92.
Liao Y, Jiang R & Lonnerdal B. 2012. Biochemical and moleculer impacts of lactoferrin on small intestinal growth and development during early life. Biochemistry and Cell Biology, 90 (3): 476-484.
Li Q & Zhao Z, 2017. Formation of lactoferrin/sodium caseinate complexes and their adsorpsion behavior at the air/water interface. Food Chemistry, 232: 697-871.
Lizzi AR, Carnicelli V, Clarkson MM, Nazzicone C, Segatore B, Celenza G et al., 2016. Bovine lactoferrin and its trypic peptides: Antibacterial activity against different species. Applied Biochemistry and Microbiology, 52 (4): 435-440.
Lonnerdal B. 2016. Bioactive proteins in human milk: health, nutritional and implications for infant formulas. The Journal of Pediatrics, 173: 54-59.
Ng TB, Chi R, Cheung F, Wong JH, Wang Y, Tsz D, Ip M, Chi D, Wan C & Xia J. 2015a. Antiviral activities of whey proteins. Appl Microbial Biotechnol, 99 (17): 6997–7008.
McGregor R & Poppit SD. 2013. Milk protein for improved metabolic health: a review of the evedence. Nutritional Metabolic, 10 (46) :1-13.
Oda H, Wakabayashi H, Yamauchi K & Abe F. 2014. Lactoferrin and bifidobacteria. BioMetals, 27 (5): 915-922.
Ostan NK, Yu RH, Ng D, Lai CCL, Pogoutse AK, Sarpe V et al., 2017. Lactoferrin binding protein B-a bi-funcional bacterial receptor protein. PLoS Pathogens, 13 (3): 100-224.
Ozer BH & Kirmaci NA. 2010. Functional milks and dairy beverages. Journal of Dairy Techonology, 63 (1): 1-15.
Paesano R, Berlutti F, Pietropaoli M, Pantanella F, Pacifici E, Goolsbee W & Valenti P. 2010. Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. Biometals,23 (3): 411-417.
Phaniendra A, Jestadi DB & Periyasamy L. 2015. Free radicals: properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry, 30 (1): 11-26.
Pietrantoni A, Dofrelli E, Tinari A, Ammendolia MG, Puzelli S, Fabiani C, Donatelli I, & Superti F. 2010. Bovine lactoferrin inhibits Influenza A virus induced programmed cell death in vitro. BioMetals, 23(3): 465-75.
Rezk M, Kandil M, Dawood R, Shaheen AE & Allam A. 2015. Oral lactoferrin versus ferrous sulphate and ferrous fumerate for the treatment of iron deficiency anemia during pregnancy. Journal of Advanced Nutritional and Human Metabolism, 2012: 1-5.
Safitri MF & Swarastuti A. 2013. Kualitas Kefir Berdasarkan Konsentrasi Kefir Grain. Jurnal Aplikasi Teknologi Pangan, 2 (2): 87-92.
Shimojima K, Isidor B, Le Caignec C, Kondo A, Sakata S, Ohno K, & Yamamoto T. 2011. A new microdeletion syndrome of 5q31.3 characterized by severe developmental delays, distinctive facial features, and delayed myelination. American Journal of Medical Genetics, Part A, 155 (4): 732-736.
Sinha M, Kaushik S, Kaur P, Sharma S & Singh TP. 2013. Antimicrobial Lactoferrin Peptides : The Hidden Players in the Protective Function of a Multifunctional Protein. Internasional Journal of Peptides, 2013: 1-12.
Siqueiros-cendón T, Arévalo-gallegos S, Iglesias-figueroa BF & Abril I. 2014. Immunomodulatory effects of lactoferrin. Nature Publishing Group, 35 (5): 557–566.
Taha F, Mehrez MA, Sitohy M, Dawood AGIA, Hamid MMA, Kilany WH. 2010. Effectiveness of esterified whey proteins fractions against Egyptian lethal avian influenza A (H5N1). Virololy Journal, 7(1): 330-333.
Uniacke-Lowe T, Huppertz T & Fox PF. 2010. Equine milk proteins: Chemistry, structure and nutritional significance. In International Dairy Journal, 20 (9): 609-629.
Van der Strate BWA, Beljaars L, Molema G, Harmsen MC, Meijer DKF. 2001. Antiviral activities of lactoferrin. Antiviral Research, 52
Vogel HJ. 2012. Lactoferrin a birds eye view. Biochemistry and Biology, 90 (3): 233-244.
Wakabayashi H, Oda H, Yamauchi K & Abe F. 2014. Lactoferrin for prevention of common viral infections. Journal of Infection and Chemotherapy, 20 (11): 666–671.
Wang B, Timilsena YP, Blanch E & Adhikari B. 2017b. Characteristics of bovine lactoferrin powders produced though spray and freeze drying processes. International Journal of Biological Macromolecules, 95: 985-994.
Wang B, Timilsena YP, Blanch E & Adhikari B. 2017c. Drying and denaturation characteristics of three forms of bovine lactoferrin. Drying Technology, 5: 606-615.
Yamamoto H, Ura Y, Tanemura M, Koyama A, Takano S, Uematsu J et al. 2010.
Efek penghambatan laktoferin sapi pada manusia infeksi virus parainfluenza tipe 2. J. Ilmu Kesehatan, 54: 613-617.
Yamanaka A, Mulyatno KC, Susilowati H, Hendrianto E, Utsumi T, Amin M, Lusida MI, Soegijanto S & Konishi E. 2010. Prevalence of antibodies to japanese encephalitis virus among pigs in Bali and East Java, Indonesia. Japanese Journal of Infectious Diseases, 63 (1): 58-60.
Yasuhara-Bell J & Lu Y. 2010. Marine compounds and their antiviral activities. In Antiviral Research, 86 (3): 231-240.
Zhang L, Luan RS, Jiang F, Rui LP, Liu M, Li YX, Yin ZD & Luo HM. 2012. Epidemiological characteristics of Japanese encephalitis in Guizhou Province, China, 1971-2009. Biomedical and Environmental Sciences, 25 (3): 297-304.
Zheng B, Wang X, Liu Y, Li Y, Long S, Gu C, Ye J, Xie S & Cao S. 2019. Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I—NF-ĸB signaling pathway. Veterinary Microbiology, 238: 108-430.
Zheng Y, Li M, Wang H & Liang G. 2012. Japanese encephalitis and Japanese encephalitis virus in mainland China. In Reviews in Medical Virology, 22 (5): 301-322.
Published
2024-11-20
How to Cite
Awa, D., Detha, A., & Saputra, A. (2024). Studi Literatur Potensi Antivirus Laktoferin Susu Kuda Terhadap Virus Japenese Encephalitis. Jurnal Veteriner Nusantara, 7(2), 218-227. https://doi.org/10.35508/jvn.v7i2.2455
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Articles
Copyright (c) 2024 Diana Rambu Naha Ana Awa, Annytha I.R Detha, Agus Saputra
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