Resistensi Larva Strongyle sp. Terhadap Albendazole pada Kambing Kacang (Capra hircus) di Indonesia
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Natasha Imanuelle(1*)
Student
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Meity M Laut(2)
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Dede Rival Novian(3)
(*) Corresponding Author
Keywords:
Resistence of albendazole, risk factors of nematodiasis, nemathodes, Strongyle sp.
Abstract
Nematodiasis is a disease of livestock which caused by nematode infestation. Nematodes in the digestive tract inhibit livestock productivity and increase mortality in young animal. Generally speaking, control of nematodiasis is done by administering anthelmintic from benzimidazole group. Albendazole is the most commonly used anthelmintic. However, continuous use of albendazole in ruminants leads to the development of resistance. The present study aims to not only investigate and evaluate Strongyle sp. larvae resistance to albendazole in Indonesia but also to determine the incident rate of albendazole resistance. This study and references were obtained through Google Scholar and PubMed then arranged using Mendeley. The references are scientific journals, scientific articles, Ebooks and proceedings with "keywords" resistance of Strongyle sp. larvae to albendazole. All references were analyzed and evaluated systematically. The result show that the resistence of Strongyle larvae against albendazole occurred in West Java, East Java, and Yogyakarta with the results of the resistence test was 67%to 89%; 77% and 83%. This results shows that the ability of the drug to treat nematodiasis is no longer optimal. The risk factors of strongyle larvae resistence to albendazole are administering sntihelmintic from the same group continously with inapropriate dose and the ability of worms to develop resistence genes against albendazole.
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References
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Besier RB, dan Love SCJ. 2003. Anthelmintic resistance in sheep nematodes in Australia: The need for new approaches. Australian Journal of Experimental Agriculture. 43(12): 1383–1391.
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Domke AVM, Chartier C, Gjerde B, Höglund J, Leine N, Vatn S, dan Stuen S. 2012. Prevalence of anthelmintic resistance in gastrointestinal nematodes of sheep and goats in Norway. Parasitology Research.111(1):185–193.
Emery DL, Hunt PW, dan Le Jambre LF. 2016. Haemonchus contortus: the then and now, and where to from here? International Journal for Parasitology. 46(12):755–769.
Fangidae PY, Nururrozi A, Yanuartono SI. 2019. Penanganan enteritis pada kambing peranakan ettawa akibat nematodiasis dan koksidiosis. Laporan Kasus. 8(2):225–237.
Gárcia CMB, Sprenger LK, Ortiz EB, dan Molento MB. 2016. First report of multiple anthelmintic resistance in nematodes of sheep in colombia. Anais Da Academia Brasileira de Ciencias. 88(1):397–402.
Garg R, Kumar RR, Yadav CL, dan Banerjee PS. 2007. Duration of anthelmintic effect of three formulations of ivermectin (oral, Injectable and pour-on) against multiple anthelmintic-resistant haemonchus contortus in sheep. Veterinary Research Communications. 31(6):749–755.
Geurden T, Chartier C, Fanke J, di Regalbono AF, Traversa D, von Samson-Himmelstjerna G, Demeler J, Vanimisetti HB, Bartram DJ, dab Denwood, MJ. 2015. Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe. International Journal for Parasitology: Drugs and Drug Resistance. 5(3):163–171.
González-Garduño R, Gives PM, dan Torres-Hernández G. 2013. Variability in the fecal egg count and the parasitic burden of hair sheep after grazing in nematode infected paddocks. Pesquisa Veterinaria Brasileira. 33(4):469–475.
Haryuningtyas D, Beriajaya, Gray GD. 2001. Resistensi antelmintik golongan benzimidazole pada kambing dan domba di indonesia. Seminar Nasional Teknologi Peternakan dan Veteriner :509–518.
Haryuningtyas D. 2005. Deteksi mutasi pada gen tubulin β isotipe-1 cacing haemonchus contortus isolat resisten terhadap benzimidazole dengan single strand conformation polymorphism. JITV. 10(3):200–207.
Indradji M, Yuwono E, Indrasanti D, Samsi M, Hastuti S, Hr A, dan Budi H. 2017. Studi kasus tingkat infeksi cacing pada peternakan kambing boer di kabupaten banyumas. Prosiding Seminar Teknologi dan Agribisnis Peternakan:375–378.
Kaplan RM, dan Vidyashankar AN. 2012. An inconvenient truth: Global worming and anthelmintic resistance. Veterinary Parasitology. 186(1–2):70–78.
Kenyon F, McBean D, Greer AW, Burgess CGS, Morrison AA, Bartley DJ, Bartley Y, Devin L, Nath M, dan Jackson F. 2013. A comparative study of the effects of four treatment regimes on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland. International Journal for Parasitology: Drugs and Drug Resistance. 3(3): 77–84.
Klauck V, Pazinato R, Lopes LS, Cucco DC, De lima HL, Volpato A, Radavelli WM, Stefani LCM, Da silva AS. 2014. Trichostrongylus and Haemonchus anthelmintic resistance in naturally infected sheep from Southern Brazil. An Acad Bras Ciênc. 86:777-784
Mahmilia F, dan Tarigan A. 2013. Karakteristik Morfologi Dan Performans Kambing Kacang , Kambing Boer Dan Persilangannya. Lokakarya Nasional Kambing Potong.
Miguel, Stig MT, Janina D, Heidi LE. 2014. Field efficacy of four anthelmintics and confirmation of drug-resistant nematodes by controlled efficacy test and pyrosequencing on a sheep and goat farm in Denmark. Veterinary Parasitology. 206:208-215
Muktar RS, Muhammad H, Muhammad H. Yudaha F, Winarudin, Zakharia HM. 2016. Perkembangan dan gambaran anatomis larva infektif (L3) Hamonchus contortus yang dibiakkan denganvermicullite. Jurnal Medika Veterinaria. 10(1):62-66.
Mukti T, Oka IBM, dan Dwinata IM. 2016. Prevalensi cacing nematoda saluran pencernaan pada kambing peranakan ettawa di kecamatan siliragung, kabupaten banyuwangi. Indonesia Medicus Veterinus. 5(4): 330–336.
Nofyan E, Kamal M, dan Rosdiana I. 2010. Identitas jenis telur cacing parasit usus pada ternak sapi (Bos sp) dan kerbau (Bubalus sp) di Rumah potong hewan palembang. Jurnal Penelitian Sains Edisi Khusus Juni, 10: 6–11.
Nunes RL, dos Santos LL, Bastianetto E, de Oliveira DAA, dan Brasil BSAF. 2013. Frequency of benzimidazole resistance in Haemonchus contortus populations isolated from buffalo, goat and sheep herds. Revista Brasileira de Parasitologia Veterinaria. 22(4): 548–553.
Oyeduntan AA, dan Emmanuel CU. 2015. Effectiveness evaluation of levamisole, albendazole, ivermectin, and vernonia amygdalina in west african dwarf goats. Parasitology Research 2015:1-6.
Preston SJM, Sandeman M, Gonzalez J, dan Piedrafita D. 2014. Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going? Journal of Immunology Research. 2014(1):1-12
Purwaningsih P, Noviyanti N, dan Sambodo P. 2017. Infestasi cacing saluran pencernaan pada kambing kacang peranakan ettawa di kelurahan amban kecamatan manokwari barat kabupaten manokwari provinsi papua barat. Jurnal Ilmiah Peternakan Terpadu. 5(1):8-12.
Puspitasari S, Farajallah A, Sulistiawati E, Muladno. 2016. Effectiveness of ivermectin and albendazole against haemonchus contortus in sheep in west java, indonesia. Tropical Life Sciences Research. 27(2):135–144.
Ramos F, Portella LP, Rodrigues FS, Reginato CZ, Pötter L, Cezar AS, Sangioni LA, dan Vogel FSF. 2016. Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil. International Journal for Parasitology: Drugs and Drug Resistance. 6(1):93–101.
Renaldy Y, Hartono M, dan Departement SS. 2019. Prevalensi cacing saluran pencernaan kambing saburai pada kelompok ternak di kecamatan gedong tataan kabupaten pesawaran. Journal of Chemical Information and Modeling. 53(9):1689–1699.
Riviere JE, dan Papich MG. 2018. Veterinary Pharmacology and Therapeutics Tenth Edition. USA: Wiley Blackwell. pp:1037.
Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, dan Upcroft P. 2002. Resistance to antiparasitic drugs: The role of molecular diagnosis. International Journal for Parasitology. 32(5): 637–653.
Sasongko ND, Adhim F, dan Zalizar L. 2019. Efficacy of anthelmintic towards gastrointestinal nematode infection in thin-tailed sheep at smallholder farms in Sukomulyo Village, Malang Regency. IOP Conference Series: Earth and Environmental Science. 247(1):1-6.
Supriyanto. 2017. Pengaruh pemberian albendazole terhadap helminthiasis sapi potong. Veterinari Parasitology: 8-18.
Winarso A. 2019. Resistensi anthelmintika: perspektif peternakan lahan kering nusa tenggara timur. Prosiding Seminar Nasional VII Fakultas Kedokteran Hewan Universitas Nusa Cendana :107–114.
Yanuartono Y, Indarjulianto S, Nururrozi A, Raharjo S, dan Purnamaningsih H. 2019. Resistensi cacing nematoda gastrointestinal terhadap golongan macrocyclic lactone pada ternak ruminansia. Ternak Tropika Journal of Tropical Animal Production. 20(2):84–99.
Zajac AM, dan Gipson TA. 2000. Multiple anthelmintic resistance in a goat herd. Veterinary Parasitology. 87(2–3): 163–172.
Badan Pusat Statistik Indonesia. 2019. Produksi Daging Kambing Menurut Provinsi 2009 sampai 2019. Jakarta: Badan Pusat Statistik Indonesia
Belina D, Abdurahman G, SM, dan AE. 2017. Gastrointestinal nematodes in ruminants : the parasite burden, associated risk factors and anthelmintic utilization practices in selected districts of east and west hararghe, ethiopia. Journal of Veterinary Science and Tech. 8(2):1-8.
Besier RB, dan Love SCJ. 2003. Anthelmintic resistance in sheep nematodes in Australia: The need for new approaches. Australian Journal of Experimental Agriculture. 43(12): 1383–1391.
Dewi DA, Martindah E, Sawitri DH, Wardhana AH, Ekawasti F. 2017. Deteksi larva cacing nematoda sebelum dan sesudah pengobatan pada beberapa bangsa domba. Prosiding Seminar Nasional Teknologi Peternakan dan Veteriner 2017:363–370.
Domke AVM, Chartier C, Gjerde B, Höglund J, Leine N, Vatn S, dan Stuen S. 2012. Prevalence of anthelmintic resistance in gastrointestinal nematodes of sheep and goats in Norway. Parasitology Research.111(1):185–193.
Emery DL, Hunt PW, dan Le Jambre LF. 2016. Haemonchus contortus: the then and now, and where to from here? International Journal for Parasitology. 46(12):755–769.
Fangidae PY, Nururrozi A, Yanuartono SI. 2019. Penanganan enteritis pada kambing peranakan ettawa akibat nematodiasis dan koksidiosis. Laporan Kasus. 8(2):225–237.
Gárcia CMB, Sprenger LK, Ortiz EB, dan Molento MB. 2016. First report of multiple anthelmintic resistance in nematodes of sheep in colombia. Anais Da Academia Brasileira de Ciencias. 88(1):397–402.
Garg R, Kumar RR, Yadav CL, dan Banerjee PS. 2007. Duration of anthelmintic effect of three formulations of ivermectin (oral, Injectable and pour-on) against multiple anthelmintic-resistant haemonchus contortus in sheep. Veterinary Research Communications. 31(6):749–755.
Geurden T, Chartier C, Fanke J, di Regalbono AF, Traversa D, von Samson-Himmelstjerna G, Demeler J, Vanimisetti HB, Bartram DJ, dab Denwood, MJ. 2015. Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe. International Journal for Parasitology: Drugs and Drug Resistance. 5(3):163–171.
González-Garduño R, Gives PM, dan Torres-Hernández G. 2013. Variability in the fecal egg count and the parasitic burden of hair sheep after grazing in nematode infected paddocks. Pesquisa Veterinaria Brasileira. 33(4):469–475.
Haryuningtyas D, Beriajaya, Gray GD. 2001. Resistensi antelmintik golongan benzimidazole pada kambing dan domba di indonesia. Seminar Nasional Teknologi Peternakan dan Veteriner :509–518.
Haryuningtyas D. 2005. Deteksi mutasi pada gen tubulin β isotipe-1 cacing haemonchus contortus isolat resisten terhadap benzimidazole dengan single strand conformation polymorphism. JITV. 10(3):200–207.
Indradji M, Yuwono E, Indrasanti D, Samsi M, Hastuti S, Hr A, dan Budi H. 2017. Studi kasus tingkat infeksi cacing pada peternakan kambing boer di kabupaten banyumas. Prosiding Seminar Teknologi dan Agribisnis Peternakan:375–378.
Kaplan RM, dan Vidyashankar AN. 2012. An inconvenient truth: Global worming and anthelmintic resistance. Veterinary Parasitology. 186(1–2):70–78.
Kenyon F, McBean D, Greer AW, Burgess CGS, Morrison AA, Bartley DJ, Bartley Y, Devin L, Nath M, dan Jackson F. 2013. A comparative study of the effects of four treatment regimes on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland. International Journal for Parasitology: Drugs and Drug Resistance. 3(3): 77–84.
Klauck V, Pazinato R, Lopes LS, Cucco DC, De lima HL, Volpato A, Radavelli WM, Stefani LCM, Da silva AS. 2014. Trichostrongylus and Haemonchus anthelmintic resistance in naturally infected sheep from Southern Brazil. An Acad Bras Ciênc. 86:777-784
Mahmilia F, dan Tarigan A. 2013. Karakteristik Morfologi Dan Performans Kambing Kacang , Kambing Boer Dan Persilangannya. Lokakarya Nasional Kambing Potong.
Miguel, Stig MT, Janina D, Heidi LE. 2014. Field efficacy of four anthelmintics and confirmation of drug-resistant nematodes by controlled efficacy test and pyrosequencing on a sheep and goat farm in Denmark. Veterinary Parasitology. 206:208-215
Muktar RS, Muhammad H, Muhammad H. Yudaha F, Winarudin, Zakharia HM. 2016. Perkembangan dan gambaran anatomis larva infektif (L3) Hamonchus contortus yang dibiakkan denganvermicullite. Jurnal Medika Veterinaria. 10(1):62-66.
Mukti T, Oka IBM, dan Dwinata IM. 2016. Prevalensi cacing nematoda saluran pencernaan pada kambing peranakan ettawa di kecamatan siliragung, kabupaten banyuwangi. Indonesia Medicus Veterinus. 5(4): 330–336.
Nofyan E, Kamal M, dan Rosdiana I. 2010. Identitas jenis telur cacing parasit usus pada ternak sapi (Bos sp) dan kerbau (Bubalus sp) di Rumah potong hewan palembang. Jurnal Penelitian Sains Edisi Khusus Juni, 10: 6–11.
Nunes RL, dos Santos LL, Bastianetto E, de Oliveira DAA, dan Brasil BSAF. 2013. Frequency of benzimidazole resistance in Haemonchus contortus populations isolated from buffalo, goat and sheep herds. Revista Brasileira de Parasitologia Veterinaria. 22(4): 548–553.
Oyeduntan AA, dan Emmanuel CU. 2015. Effectiveness evaluation of levamisole, albendazole, ivermectin, and vernonia amygdalina in west african dwarf goats. Parasitology Research 2015:1-6.
Preston SJM, Sandeman M, Gonzalez J, dan Piedrafita D. 2014. Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going? Journal of Immunology Research. 2014(1):1-12
Purwaningsih P, Noviyanti N, dan Sambodo P. 2017. Infestasi cacing saluran pencernaan pada kambing kacang peranakan ettawa di kelurahan amban kecamatan manokwari barat kabupaten manokwari provinsi papua barat. Jurnal Ilmiah Peternakan Terpadu. 5(1):8-12.
Puspitasari S, Farajallah A, Sulistiawati E, Muladno. 2016. Effectiveness of ivermectin and albendazole against haemonchus contortus in sheep in west java, indonesia. Tropical Life Sciences Research. 27(2):135–144.
Ramos F, Portella LP, Rodrigues FS, Reginato CZ, Pötter L, Cezar AS, Sangioni LA, dan Vogel FSF. 2016. Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil. International Journal for Parasitology: Drugs and Drug Resistance. 6(1):93–101.
Renaldy Y, Hartono M, dan Departement SS. 2019. Prevalensi cacing saluran pencernaan kambing saburai pada kelompok ternak di kecamatan gedong tataan kabupaten pesawaran. Journal of Chemical Information and Modeling. 53(9):1689–1699.
Riviere JE, dan Papich MG. 2018. Veterinary Pharmacology and Therapeutics Tenth Edition. USA: Wiley Blackwell. pp:1037.
Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, dan Upcroft P. 2002. Resistance to antiparasitic drugs: The role of molecular diagnosis. International Journal for Parasitology. 32(5): 637–653.
Sasongko ND, Adhim F, dan Zalizar L. 2019. Efficacy of anthelmintic towards gastrointestinal nematode infection in thin-tailed sheep at smallholder farms in Sukomulyo Village, Malang Regency. IOP Conference Series: Earth and Environmental Science. 247(1):1-6.
Supriyanto. 2017. Pengaruh pemberian albendazole terhadap helminthiasis sapi potong. Veterinari Parasitology: 8-18.
Winarso A. 2019. Resistensi anthelmintika: perspektif peternakan lahan kering nusa tenggara timur. Prosiding Seminar Nasional VII Fakultas Kedokteran Hewan Universitas Nusa Cendana :107–114.
Yanuartono Y, Indarjulianto S, Nururrozi A, Raharjo S, dan Purnamaningsih H. 2019. Resistensi cacing nematoda gastrointestinal terhadap golongan macrocyclic lactone pada ternak ruminansia. Ternak Tropika Journal of Tropical Animal Production. 20(2):84–99.
Zajac AM, dan Gipson TA. 2000. Multiple anthelmintic resistance in a goat herd. Veterinary Parasitology. 87(2–3): 163–172.
Published
2023-03-31
How to Cite
Imanuelle, N., Laut, M., & Novian, D. (2023). Resistensi Larva Strongyle sp. Terhadap Albendazole pada Kambing Kacang (Capra hircus) di Indonesia. Jurnal Veteriner Nusantara, 6(1), 128-142. https://doi.org/10.35508/jvn.v6i1.2791
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Articles
Copyright (c) 2023 Natasha Imanuelle, Meity M Laut, Dede Rival Novian
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
