Review : Porcine Epidemic Diarrhea pada Anak Babi
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Korbinianus Feribertus Rinca(1)
Universitas Nusa Cendana
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I Putu Cahyadi Putra(2*)
Universitas Udayana
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Ni Wayan Helpina Widyasanti(3)
Universitas Udayana
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Aletha Yuliana Mandala(4)
Universitas Nusa Cendana
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Mariana Febrilianti Resilinda Putri(5)
Universitas Nusa Cendana
(*) Corresponding Author
Keywords:
Piglets, porcine epidemic diarrhea, a review
Abstract
Porcine Epidemic Diarrhea (PED) is a disease caused by the Porcine epidemic diarrhea virus (PEDV). This article aims to provide knowledge about epidemiology, virus characteristics, transmission, pathogenesis and clinical symptoms, anatomical pathology, histopathology, diagnosis, prevention, and control of PEDs. The method used was reviewing articles that have been published in non-reputable and reputable international journals in the last 15 years, which were searched using Google Scholar, Crossref, and Sciencedirect. This review shows PEDs have spread both directly and indirectly to various continents such as Europe, America, and Asia but have never been reported in Indonesia. PED disease attacks all ages of pigs, but the highest mortality rate occurs in piglets with the intestine as the predilection organ for the virus. Anatomical pathology lesions on PED show the form of thinning in the small intestine of infected animal but no bleeding is observed. In addition, the histopathological lesions were observed for intestinal inflammation or enteritis. Diagnosis of the disease can be carried out microscopically, macroscopically, molecularly, and serologically. Prevention can be achieved through the introduction of biosecurity, alternative therapies, and administration of vaccines. Based on the review results, it can be concluded that PEDs have spread to various parts of the world causing high mortality in piglets due to effacement and inflammation of the small intestine. It is hoped that the article review will provide knowledge about PEDs for pig farmers.
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References
Alonso, C., Goede, D. P., Morrison, R. B., Davies, P. R., Rovira, A., and Marthaler, D. G. (2014). Evidence Of Infectivity of Airborne Porcine Epidemic Diarrhoea Virus and Detection of Airborne Viral RNA At Long Distances From Infected Herds. Veterinary Research. 45(1):1–5.
Baek, G, W., Kang, B. K., Park, S. J., , C. S., Oh, J. S., Chai, Y. G., Park, B. K., and Moon, H. J. (2010). The Correlation and Accuracy of Glucose Levels Between Interstitial Fluid and Venous Plasma by Continuous Glucose Monitoring System. Korean Diabetes Journal. 34(6): 350–358.
Bowman, A. S., Krogwold, R. A., Price, T., Davis, M., Moeller, S. J. (2015). Investigating the Introduction of Porcine Epidemic Diarrhea Virus Into An Ohio Swine Operation. BMC Veterinary Research. 11(1) : 381-387.
Carvajal, A., Argüello, H., Martínez-Lobo, F. J., Costillas, S., Miranda, R., De Nova, P. J. G., and Rubio P. 2015. Porcine Epidemic Diarrhoea: New Insights Into An Old Disease. Porcine Health Management. 1:121-128.
Chen, J., Liu, X., Shi, D., Shi, H., Zhang, X., and Feng, L. (2012). Complete Genome Sequence of A Porcine Epidemic Diarrhea Virus Variant. Journal of Virology. 86 (24) :34081-34084.
Chen, J., Wang, C., Shi, H., Qiu, H., Liu, S., and Chen, X. (2010). Molecular Epidemiology of Porcine Epidemic Diarrhoea Virus in China. Archives of Virology. 155 (9) :1471–1476.
Chen, Q., Gauger, P., Stafne, M., Thomas, J., Arruda, P., and Burrough, E. (2015). Pathogenicity and Pathogenesis of A United States Porcine Deltacoronavirus Cell Culture Isolate in 5-Day-Old Neonatal Piglets. Virology. 482:51–59.
Chen, X., Zhang, X. X., Li, C., Wang, H., Wang, H., Meng, X. Z., Ma, J., Ni, H. B., Zhang, X., Qi, Y., and Sun, D. (2019). Epidemiology of Porcine Epidemic Diarrhea Virus Among Chinese Pig Populations: A Meta-Analysis. Microbial Pathogenesis. 129:43–49.
Collin, E. A., Anbalagan, S., Okda, F., Batman, R., Nelson, E., and Hause, B. M. (2015). An Inactivated Vaccine Made from A U.S. Field Isolate of Porcine Epidemic Disease Virus is Immunogenic in Pigs As Demonstrated By A Dose-Titration. BMC Veterinary Research. 11 (1) :621-629.
Dee, S., Clement, T., Schelkopf, A., Nerem, J., Knudsen, D., and Christopher-Hennings, J. (2014). An Evaluation of Contaminated Complete Feed As A Vehicle for Porcine epidemic Diarrhoea Virus Infection of Naive Pigs Following Consumption Via Natural Feeding Behaviour: Proof of Concept. BMC Veterinary Research. 10 (1) :1761-1769.
Dhamayanti, N. P. I., and Nurjanah, D. (2020). A Review On Coronaviruses : The Agent to Animals and Human. Wartazoa. 30 (1) : 1-14.
Diel, D. G., Lawson, S., Okda, F., Singrey, A., Clement, T., Fernandes, M. H., Christopher-Hennings, J., and Nelson, E. A. (2016). Porcine Epidemic Diarrhea Virus: An Overview of Current Virological and Serological Diagnostic Methods. Virus Research. 226:60–70.
Do, T. D., Nguyen, T. T., Srijangwad, P., and Roongroje, T. (2011). Genetic Characterization of Porcine Epidemic Diarrhea Virus (PEDV) Isolates from Southern Vietnam During 2009–2010 Outbreaks. Thai Journal Veterinary Medicine. 41 (1) :55–64.
EFSA AHAW (EFSA Panel On Animal Health And Welfare). (2014). Scientific Opinion On Porcine Epidemic Diarrhoea And Emerging Pig Deltacoronavirus. EFSA J. 12:387.
Fehr, A. R., and Perlman, S. (2015). Coronaviruses: An Overview off Their Replication and Pathogenesis. Nature Public Health Emergency Collection, 1282 : 1–23.
Gerber, P. F., and Opriessnig, T. (2015). Detection of Immunoglobulin (Ig) A Antibodies Against Porcine Epidemic Diarrhea Virus (PEDV) in Fecal and Serum Samples. Methodsx. 2:368–373.
Gong, L., Lin, Y., Qin, J., Li, Q., Xue, C., and Cao, Y. (2018). Neutralizing Antibodies Against Porcine Epidemic Diarrhea Virus Block Virus Attachment and Internalization. Virology Journal. 15(1) : 1331-1339.
Grasland, B., Bigault, L., Bernard, C., Quenault, H., Toulouse, O., and Fablet. (2015). Complete Genome Sequence of A Porcine Epidemic Diarrhea S Gene Indel Strain Isolated in France in December 2014. Genome announcements. 3 (3) :E00535.
Guo, J., Fang, L., Ye, X., Chen, J., Xu, S., Zhu, X., Miao, Y., Wang, D., and Xiao, S. (2019). Evolutionary and Genotypic Analyses of Global Porcine Epidemic Diarrhea Virus Strains. Transboundary and Emerging Diseases.. 66 (1) :111–118.
Hanke, D., Jenckel, M., Petrov, A., Ritzmann, M., Stadler, J., and Akimkin, V. (2015). Comparison of Porcine Epidemic Diarrhea Viruses From Germany and The United States, 2014. Emerging Infectious Diseases. 21(3): 493–496.
Hesse, D., Suddith, A., Breazeale, B., Fuller, A., Concannon, C., and Anderson. (2014). Oral/Nasal Inoculation Of Four-Week-Old Pigs With PEDV: Tissue Tropism,Shedding, Carriage, Antibody Response, And Aerosol Transmission. Proc 23rd International Pig Veterinary Society Congress. Cancun, Mexico, May 12, 2015. Pp : 1-17.
Jang, G., Lee, D., Shin, S., Lim, J., Won, H., Eo, Y., Kim, C., and Lee, C. (2023). Porcine epidemic diarrhea virus: An update overview of virus epidemiology, vaccines, and control strategies in South Korea. Journal of Veterinary Science, 24(4).
Jasna, P. R., Tamaš, P., Diana, L., Doroteja, M., Jelena, Živoslav, P. G., and Sava, L. (2017). First Detection and Clinical Presentation of Porcine Epidemic Diarrhea Virus (PEDV) in Serbia. Acta Veterinaria. 67 (3) : 383-396.
Ji, C. M., Wang, B., Zhou, J., and Huang, Y. W. (2018). Aminopeptidase-N-Independent Entry Of Porcine Epidemic Diarrhea Virus Into Vero or Porcine Small Intestine Epithelial Cells. Virology. 517 : 16–23.
Jung, K., and Saif, L. J. (2015). Porcine Epidemic Diarrhoea Virus Infection: Etiology, Epidemiology, Pathogenesis and Immunoprophylaxis. The Veterinary Journal. 204 (2) :134–143.
Jung, K., Saif, L. J., and Wang, Q. (2020). Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control. Virus research, 286, 198045.
Jung, K., Wang, Q., Scheuer, K. A., Lu, Z., Hang, Y., and Saif, L. J. (2014). Pathology of US Porcine Epidemic Diarrhea Virus Strain PC21A in Gnotobiotic Pigs. Emerging Infectious Diseases. 20(4): 662–665.
Karte, C., Platje, N., Bullermann, J. Bullermann, J., Beer, M., Hoper, D., and Blome, S. (2020). Re-emergence of porcine epidemic diarrhea virus in a piglet-producing farm in northwestern Germany in 2019. BMC Vet Res 16, 329.
Kim, Y. K., Cho, Y. Y., and An, B. H. (2016). Molecular Characterization Of The Spike And ORF3 Genes Of Porcine Epidemic Diarrhea Virus In The Philippines. Archives of Virology. 161 (5) :1323–1328.
Kim, Y., and Lee, C. (2014). Porcine Epidemic Diarrhea Virus Induces Caspase-Independent Apoptosis Through Activation of Mitochondrial Apoptosis-Inducing Factor. Virology. 460–461:180–193.
Kim, Y., Yang, M., Goyal, S. M., Cheeran, M. C., and Torremorell, M. (2017). Evaluation of Biosecurity Measures to Prevent Indirect Transmission of Porcine Epidemid Diarrhea Virus. BMC Veterinary Research. 13 (1) :891-899.
Kipar, A., and Meli, M. L. (2015). Feline Infectious Peritonitis: Still An Enigma?. Veterinary Pathology. 51(2):505-26.
Lee, D. H., Jeon, Y. S., Park, C. K., Kim, S. J., Lee, D. S., An, L. C. (2015b). Immunoprophylactic Effect of Chicken Egg Yolk Antibody (Igy) Against A Recombinant S1 Domain of the
Porcine Epidemic Diarrhea Virus Spike Protein in Piglets. Archives of Virology. 160 (9):
2197–2207
Lee, J. H., Song, D. S., Jeong, H. K., Shon, J. H., Park, B. K., and Joo, H. S. (2015c). Experimental Inoculation With PEDV In Sparrows and Mice. Prociding 23rd International Pig Veterinary Society Congress. Cancun, Mexico; May 12, 2015
Lee, S., and Lee, C. (2014a). Outbreak-Related Porcine Epidemic Diarrhea Virus Strains Similar to US Strains, South Korea, 2013. Emerging Infectious Diseases. 20 (7) :1223–1226.
Lee, S., Kim, Y., and Lee, C. (2015a). Isolation and Characterization of A Korean Porcine Epidemic Diarrhea Virus Strain KNU-141112. Virus Research. 208:215–224.
Lee, S., Ko, D. H., Kwak, S. K., Lim, C. H., Moon, S. U., and Lee, D. S. (2014b). Reemergence of Porcine Epidemic Diarrhea Virus on Jeju Island. Korean Journal of Veterinary Research. 54 (4) :185–188.
Li, W., Li, H., Liu, Y., Pan, Y., Deng, F., and Song, Y. (2012). New Variants of Porcine Epidemic Diarrhea Virus, China, 2011. Emerging Infectious Diseases. 18 (8) :1350–1353.
Liang W, Zhou D, Geng C, Yang K, Duan Z, Guo R, Liu W, Yuan F, Liu Z, Gao T, Zhao L, Yoo D, Tian Y. (2020). Isolation and evolutionary analyses of porcine epidemic diarrhea virus in Asia. PeerJ 8:e10114
Lowe, J., Gauger, P., Harmon, K., Zhang, J., Connor, J., and Yeske, P., Loula, T., Levis, I., Dufresne, L., and Main, R. (2014). Role of Transportation in Spread Of Porcine Epidemic Diarrhoea Virus Infection,United States. Emerging Infectious Diseases. 20 (5) :872-874.
Ma, Y., Xueyah, Y., Liang X., Lou F., Oglesbee, M., and Krakowka. (2015). Origin,
Evolution, and Virulence Of Porcine Delta coronaviruses in the United States.
Mbio. 60 (2) :E00064.
Madson, D. M., Arruda, P. H., Magstadt, D. R., Burrough, E. R.., Hoang, H., Sun, D., and Yoon, K. J. (2015). Characterization of Porcine Epidemic Diarrhea Virus Isolate US/Iowa/18984/2013 Infection In 1‐Day‐Old Cesarean‐Derived Colostrum‐Deprived Piglets. Veterinary Pathology. 53 (1) : 44–52.
Madson, D. M., Magstadt, D. R., Arruda, P. H., Hoang, H., Sun, D., and Bower. L. P. (2014). Pathogenesis of Porcine Epidemic Diarrhoea Virus Isolate (US/Iowa/18984/ 2013) In 3-Week-Old Weaned Pigs. Veterinary Microbiology. 174(1-2):60-68.
Marthaler, D., Jiang, Y., Otterson, T., Goyal, S., Rossow, K., and Collins, J. (2013). Complete Genome Sequence of Porcine Epidemic Diarrhea Virus Strain USA/Colorado/2013 from The United States. Genome Announcements. 1(4) :E00555-13.
Niederwerder, M. C., Nietfeld, J. C., Bai, J., Peddireddi, L., Breazeale, B., Anderson, J., and Hesse, R. A. (2016). Tissue Localization, Shedding, Virus Carriage, Antibody Response, and Aerosol Transmission of Porcine Epidemic Diarrhea Virus Following Inoculation of 4‐Week‐Old Feeder Pigs. Journal Of Veterinary Diagnostic Investigation. 28 (6) :671–678.
OIE. (2020). World Animal Health Information System (WAHIS): Jul-Dec. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/
Opressnig, T. (2016). Porcine Epidemic Diarrhea (PED) in Europe and Strategies to Control Outbreaks. The Japanese Journal Of Veterinary Research. 64 (1) : 35–38.
Pan, Y., Tian, X., Li, W., Zhou, Q., Wang, D., Bi, Y., Chen, F., and Song, Y. (2012). Isolation and Characterization of A Variant Porcine Epidemic Diarrhea Virus in China. Virology Journal. 9: 195–204.
Park, C. K., Lee, K. and K., Lee, C. (2011). PED Past, Present, and Future. Asian Pig Veterinary Society Congress. 19–20.
Park, J. E., and Shin, H. J. (2014). Porcine Epidemic Diarrhoea Virus Infects and Replicates in Porcine Alveolar Macrophages. Virus Research. 191:143–152.
Pizzurro, F., Cito, F., Zaccaria, G., Spedicato, M., Cerella, A., Orsini, M., Forzan, M., D’Alterio, N., Lorusso, A., and Marcacci, M. (2018). Outbreak of Porcine Epidemic Diarrhoea Virus (PEDV) in Abruzzi Region, Central-Italy. Veterinary Medicine and Science. 4 (2) : 73-79.
Puranaveja, S., Poolperm, P., Lertwatcharasarakul, P., Kesdaengsakonwut, S., Boonsoongnern, A., Urairong, K., Kitikoon, P., Choojai, P., Kedkovid, R., Teankum, K., Thanawongnuwech, R. (2009). Chinese-like strain of porcine epidemic diarrhea virus, Thailand. Emerg Infect Dis. 15:1112–1115.
Qian, S., Zhang, W., Jia, X., Sun, Z., Zhang, Y., Xiao, Y., and Li, Z. (2019). Isolation and Identification of Porcine Epidemic Diarrhea Virus and Its Effect on Host Natural Immune Response. Frontier in Microbiology. 10: 2272.
Ren, X., Suo, S., and Jang, Y. S. (2011). Development of A Porcine Epidemic Diarrhea Virus M Protein-Based ELISA for Virus Detection. Biotechnology Letters. 33 (2) :215–220.
Sasaki, Y., Alvarez, J., Sekiguchi, S., Sueyoshi, M., Otake, S., and Perez, A. (2016). Epidemiological Factors Associated to Spread of Porcine Epidemic Diarrhea in Japan. Preventive Veterinary Medicine. 123:161–167.
Sato, T., Takeyama, N., Katsumata, A., Tuchiya, K., Kodama, T., and Kusanagi, K. (2011).
Mutations in the Spike Gene of Porcine Epidemic Diarrhea Virus Associated
With Growth Adaptation in Vitro and Attenuation of Virulence In Vivo. Virus
Genes. 43 (1) :72–78.
Schumacher, L. L., Cochrane, R. A., Huss, A. R., Gebhardt, J. T., Woodworth, J. C., Stark, C. R., Jones, C. K., Bai, J., Main, R. G., Chen, Q., Zhang, J., Gauger, P. C., Derouchey, J. M,. Goodband, R. D., Tokach, M. D., and Dritz, S. S. (2018). Feed Batch Sequencing to Decrease the Risk of Porcine Epidemic Diarrhea Virus (PEDV) Cross-Contamination During Feed Manufacturing. Journal of Animal Science. 96 (11) :4562-4570.
Schumacher, L. L., Huss, A. R., Cochrane, R. A., Stark, C. R., Woodworth, J. C., Bai, J., Poulsen, E. G., Chen, Q., Main, R. G., Zhang, J., Gauger, P. C., Ramirez, A., Derscheid, R. J., Magstadt, D. M., Dritz, S. S., and Jones, C. K. (2017). Characterizing the Rapid Spread of Porcine Epidemic Diarrhea Virus (PEDV) Through An Animal Food Manufacturing Facility. Plos One. 12 (11) : E0187309
Schwartz, K., Henry, S., Tokach, L., Potter, M., Davidson, D., and Egnor, C. (2014). Exposing Sows to PEDV to Build Herd Immunity [Internet]. [Cited Agust 11, 2022] Available From :Http://Nationalhogfarmer.Com/Business/Exposing-Sows-Pedv-Build-Herd-Immunity.
Song, D., and Park, B. (2012). Porcine Epidemic Diarrhoea Virus: A Comprehensive Review of Molecular Epidemiology, Diagnosis, and Vaccines. Virus Genes. 44 (2) : 167–175.
Song, D., Moon, H., and Kang, B. (2015). Porcine Epidemic Diarrhea: A Review of Current Epidemiology and Available Vaccines. Clinical and Experimental Vaccine Research. 4 (2) :166–176.
Sozzi, E., Luppi, A., Lelli, D., Martin, A. M., Canelli, E., and Brocchi, E. (2010). Comparison of Enzyme-Linked Immunosorbent Assay and RT-PCR for the Detection of Porcine Epidemic Diarrhoea Virus. Research in Veterinary Science. 88 (1) :166–168.
Stevenson, G. W., Hoang, H., Schwartz, K. J., Burrough, E. B., Sun, D., Madson, D., Cooper, V. L., Pillatzki, A., Gauger, P., and Schmitt, B. J. (2013). Emergence of Porcine Epidemic Diarrhea Virus in The United States: Clinical Signs, Lesions, and Viral Genomic Sequences. Journal of Veterinary Diagnostic Investigation. 25 (5) :649–654.
Sun, R. Q., Cai, R. J., Chen, Y. Q., Liang, P. S., Chen, D. K., and Song, C. X. (2012). Outbreak of Porcine Epidemic Diarrhea in Suckling Piglets, China. Emerging Infectious Diseases. 18 (1) :161–163.
Sun, R., Leng, Z., Dekun, C., and Song, C. (2014). Multiple Factors Contribute to Persistent Porcine Epidemic Diarrhoea Infection in the Field: An Investigation on Porcine Epidemic Diarrhoea Repeated Outbreaks in the Same Herd. Journal of Animal and Veterinary Advances. 13 (6) :410–415.
Theuns, S., Conceição-Neto, N., Christiaens, I., Zeller, M., Desmarets, L. M., and Roukaerts, I. D. Complete Genome Sequence of A Porcine Epidemic Diarrhea Virus From A Novel Outbreak In Belgium, January 2015. Genome announcements.3 (3) :E00506-15.
Tian, Y., Yu, Z., and Cheng, K. (2013). Molecular Characterization and Phylogenetic Analysis of New Variants of the Porcine Epidemic Diarrhea Virus in Gansu, China in 2012. Viruses. 5 (8) :1991–2004.
Turlewicz-Podbielska, H., and Pomorska-Mól, M. (2021). Porcine Coronaviruses: Overview of the State of the Art. Virol. Sin. 36, 833–851.
Wang, J., Zhao, P., and Guo, L. (2013). Porcine Epidemic Diarrhea Virus Variants With High Pathogenicity, China. Emerging Infectious Diseases. 19 (12) : 2048–2049.
Won, H., Lim, J., Noh, Y. H., Yoon, I., and Yoo, H. S. (2020). Efficacy of porcine epidemic diarrhea vaccines: A systematic review and meta-analysis. Vaccines, 8(4), 642.
Woo, P. C. Y., Huang, Yi., Lau, K. P. L., and Yuen, K. W. (2010). Corona Virus Genomics and Bioinformatics Analysis.Viruses. 2 (8) :1804-1820.
Woo, P., Lau, S., Lam, C., Lau, C., Tsang, A., and Lau, J. (2012). Discovery of Seven Novel Mammalian and Avian Coronaviruses in Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alpacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus. Journal of Virology. 32 (7) :3995–4008
Xu, X., Zhang, H., Zhang, Q., Huang, Y., Dong, J., and Liang, Y. (2013). Porcine Epidemic Diarrhea Virus N Protein Prolongs S-Phase Cell Cycle, Induces Endoplasmic Reticulum Stress, And Up-Regulates Interleukin-8 Expression. Veterinary Microbiology. 164 (3-4) :212–221.
Zhang, Y., Chen, Y., Zhou, J., Wang, X., Ma, L., Li, J., Yang, L., Yuan, H., Pang, D., and Ouyang, H. (2022). Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions. Viruses, 14(11), 2434.
Baek, G, W., Kang, B. K., Park, S. J., , C. S., Oh, J. S., Chai, Y. G., Park, B. K., and Moon, H. J. (2010). The Correlation and Accuracy of Glucose Levels Between Interstitial Fluid and Venous Plasma by Continuous Glucose Monitoring System. Korean Diabetes Journal. 34(6): 350–358.
Bowman, A. S., Krogwold, R. A., Price, T., Davis, M., Moeller, S. J. (2015). Investigating the Introduction of Porcine Epidemic Diarrhea Virus Into An Ohio Swine Operation. BMC Veterinary Research. 11(1) : 381-387.
Carvajal, A., Argüello, H., Martínez-Lobo, F. J., Costillas, S., Miranda, R., De Nova, P. J. G., and Rubio P. 2015. Porcine Epidemic Diarrhoea: New Insights Into An Old Disease. Porcine Health Management. 1:121-128.
Chen, J., Liu, X., Shi, D., Shi, H., Zhang, X., and Feng, L. (2012). Complete Genome Sequence of A Porcine Epidemic Diarrhea Virus Variant. Journal of Virology. 86 (24) :34081-34084.
Chen, J., Wang, C., Shi, H., Qiu, H., Liu, S., and Chen, X. (2010). Molecular Epidemiology of Porcine Epidemic Diarrhoea Virus in China. Archives of Virology. 155 (9) :1471–1476.
Chen, Q., Gauger, P., Stafne, M., Thomas, J., Arruda, P., and Burrough, E. (2015). Pathogenicity and Pathogenesis of A United States Porcine Deltacoronavirus Cell Culture Isolate in 5-Day-Old Neonatal Piglets. Virology. 482:51–59.
Chen, X., Zhang, X. X., Li, C., Wang, H., Wang, H., Meng, X. Z., Ma, J., Ni, H. B., Zhang, X., Qi, Y., and Sun, D. (2019). Epidemiology of Porcine Epidemic Diarrhea Virus Among Chinese Pig Populations: A Meta-Analysis. Microbial Pathogenesis. 129:43–49.
Collin, E. A., Anbalagan, S., Okda, F., Batman, R., Nelson, E., and Hause, B. M. (2015). An Inactivated Vaccine Made from A U.S. Field Isolate of Porcine Epidemic Disease Virus is Immunogenic in Pigs As Demonstrated By A Dose-Titration. BMC Veterinary Research. 11 (1) :621-629.
Dee, S., Clement, T., Schelkopf, A., Nerem, J., Knudsen, D., and Christopher-Hennings, J. (2014). An Evaluation of Contaminated Complete Feed As A Vehicle for Porcine epidemic Diarrhoea Virus Infection of Naive Pigs Following Consumption Via Natural Feeding Behaviour: Proof of Concept. BMC Veterinary Research. 10 (1) :1761-1769.
Dhamayanti, N. P. I., and Nurjanah, D. (2020). A Review On Coronaviruses : The Agent to Animals and Human. Wartazoa. 30 (1) : 1-14.
Diel, D. G., Lawson, S., Okda, F., Singrey, A., Clement, T., Fernandes, M. H., Christopher-Hennings, J., and Nelson, E. A. (2016). Porcine Epidemic Diarrhea Virus: An Overview of Current Virological and Serological Diagnostic Methods. Virus Research. 226:60–70.
Do, T. D., Nguyen, T. T., Srijangwad, P., and Roongroje, T. (2011). Genetic Characterization of Porcine Epidemic Diarrhea Virus (PEDV) Isolates from Southern Vietnam During 2009–2010 Outbreaks. Thai Journal Veterinary Medicine. 41 (1) :55–64.
EFSA AHAW (EFSA Panel On Animal Health And Welfare). (2014). Scientific Opinion On Porcine Epidemic Diarrhoea And Emerging Pig Deltacoronavirus. EFSA J. 12:387.
Fehr, A. R., and Perlman, S. (2015). Coronaviruses: An Overview off Their Replication and Pathogenesis. Nature Public Health Emergency Collection, 1282 : 1–23.
Gerber, P. F., and Opriessnig, T. (2015). Detection of Immunoglobulin (Ig) A Antibodies Against Porcine Epidemic Diarrhea Virus (PEDV) in Fecal and Serum Samples. Methodsx. 2:368–373.
Gong, L., Lin, Y., Qin, J., Li, Q., Xue, C., and Cao, Y. (2018). Neutralizing Antibodies Against Porcine Epidemic Diarrhea Virus Block Virus Attachment and Internalization. Virology Journal. 15(1) : 1331-1339.
Grasland, B., Bigault, L., Bernard, C., Quenault, H., Toulouse, O., and Fablet. (2015). Complete Genome Sequence of A Porcine Epidemic Diarrhea S Gene Indel Strain Isolated in France in December 2014. Genome announcements. 3 (3) :E00535.
Guo, J., Fang, L., Ye, X., Chen, J., Xu, S., Zhu, X., Miao, Y., Wang, D., and Xiao, S. (2019). Evolutionary and Genotypic Analyses of Global Porcine Epidemic Diarrhea Virus Strains. Transboundary and Emerging Diseases.. 66 (1) :111–118.
Hanke, D., Jenckel, M., Petrov, A., Ritzmann, M., Stadler, J., and Akimkin, V. (2015). Comparison of Porcine Epidemic Diarrhea Viruses From Germany and The United States, 2014. Emerging Infectious Diseases. 21(3): 493–496.
Hesse, D., Suddith, A., Breazeale, B., Fuller, A., Concannon, C., and Anderson. (2014). Oral/Nasal Inoculation Of Four-Week-Old Pigs With PEDV: Tissue Tropism,Shedding, Carriage, Antibody Response, And Aerosol Transmission. Proc 23rd International Pig Veterinary Society Congress. Cancun, Mexico, May 12, 2015. Pp : 1-17.
Jang, G., Lee, D., Shin, S., Lim, J., Won, H., Eo, Y., Kim, C., and Lee, C. (2023). Porcine epidemic diarrhea virus: An update overview of virus epidemiology, vaccines, and control strategies in South Korea. Journal of Veterinary Science, 24(4).
Jasna, P. R., Tamaš, P., Diana, L., Doroteja, M., Jelena, Živoslav, P. G., and Sava, L. (2017). First Detection and Clinical Presentation of Porcine Epidemic Diarrhea Virus (PEDV) in Serbia. Acta Veterinaria. 67 (3) : 383-396.
Ji, C. M., Wang, B., Zhou, J., and Huang, Y. W. (2018). Aminopeptidase-N-Independent Entry Of Porcine Epidemic Diarrhea Virus Into Vero or Porcine Small Intestine Epithelial Cells. Virology. 517 : 16–23.
Jung, K., and Saif, L. J. (2015). Porcine Epidemic Diarrhoea Virus Infection: Etiology, Epidemiology, Pathogenesis and Immunoprophylaxis. The Veterinary Journal. 204 (2) :134–143.
Jung, K., Saif, L. J., and Wang, Q. (2020). Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control. Virus research, 286, 198045.
Jung, K., Wang, Q., Scheuer, K. A., Lu, Z., Hang, Y., and Saif, L. J. (2014). Pathology of US Porcine Epidemic Diarrhea Virus Strain PC21A in Gnotobiotic Pigs. Emerging Infectious Diseases. 20(4): 662–665.
Karte, C., Platje, N., Bullermann, J. Bullermann, J., Beer, M., Hoper, D., and Blome, S. (2020). Re-emergence of porcine epidemic diarrhea virus in a piglet-producing farm in northwestern Germany in 2019. BMC Vet Res 16, 329.
Kim, Y. K., Cho, Y. Y., and An, B. H. (2016). Molecular Characterization Of The Spike And ORF3 Genes Of Porcine Epidemic Diarrhea Virus In The Philippines. Archives of Virology. 161 (5) :1323–1328.
Kim, Y., and Lee, C. (2014). Porcine Epidemic Diarrhea Virus Induces Caspase-Independent Apoptosis Through Activation of Mitochondrial Apoptosis-Inducing Factor. Virology. 460–461:180–193.
Kim, Y., Yang, M., Goyal, S. M., Cheeran, M. C., and Torremorell, M. (2017). Evaluation of Biosecurity Measures to Prevent Indirect Transmission of Porcine Epidemid Diarrhea Virus. BMC Veterinary Research. 13 (1) :891-899.
Kipar, A., and Meli, M. L. (2015). Feline Infectious Peritonitis: Still An Enigma?. Veterinary Pathology. 51(2):505-26.
Lee, D. H., Jeon, Y. S., Park, C. K., Kim, S. J., Lee, D. S., An, L. C. (2015b). Immunoprophylactic Effect of Chicken Egg Yolk Antibody (Igy) Against A Recombinant S1 Domain of the
Porcine Epidemic Diarrhea Virus Spike Protein in Piglets. Archives of Virology. 160 (9):
2197–2207
Lee, J. H., Song, D. S., Jeong, H. K., Shon, J. H., Park, B. K., and Joo, H. S. (2015c). Experimental Inoculation With PEDV In Sparrows and Mice. Prociding 23rd International Pig Veterinary Society Congress. Cancun, Mexico; May 12, 2015
Lee, S., and Lee, C. (2014a). Outbreak-Related Porcine Epidemic Diarrhea Virus Strains Similar to US Strains, South Korea, 2013. Emerging Infectious Diseases. 20 (7) :1223–1226.
Lee, S., Kim, Y., and Lee, C. (2015a). Isolation and Characterization of A Korean Porcine Epidemic Diarrhea Virus Strain KNU-141112. Virus Research. 208:215–224.
Lee, S., Ko, D. H., Kwak, S. K., Lim, C. H., Moon, S. U., and Lee, D. S. (2014b). Reemergence of Porcine Epidemic Diarrhea Virus on Jeju Island. Korean Journal of Veterinary Research. 54 (4) :185–188.
Li, W., Li, H., Liu, Y., Pan, Y., Deng, F., and Song, Y. (2012). New Variants of Porcine Epidemic Diarrhea Virus, China, 2011. Emerging Infectious Diseases. 18 (8) :1350–1353.
Liang W, Zhou D, Geng C, Yang K, Duan Z, Guo R, Liu W, Yuan F, Liu Z, Gao T, Zhao L, Yoo D, Tian Y. (2020). Isolation and evolutionary analyses of porcine epidemic diarrhea virus in Asia. PeerJ 8:e10114
Lowe, J., Gauger, P., Harmon, K., Zhang, J., Connor, J., and Yeske, P., Loula, T., Levis, I., Dufresne, L., and Main, R. (2014). Role of Transportation in Spread Of Porcine Epidemic Diarrhoea Virus Infection,United States. Emerging Infectious Diseases. 20 (5) :872-874.
Ma, Y., Xueyah, Y., Liang X., Lou F., Oglesbee, M., and Krakowka. (2015). Origin,
Evolution, and Virulence Of Porcine Delta coronaviruses in the United States.
Mbio. 60 (2) :E00064.
Madson, D. M., Arruda, P. H., Magstadt, D. R., Burrough, E. R.., Hoang, H., Sun, D., and Yoon, K. J. (2015). Characterization of Porcine Epidemic Diarrhea Virus Isolate US/Iowa/18984/2013 Infection In 1‐Day‐Old Cesarean‐Derived Colostrum‐Deprived Piglets. Veterinary Pathology. 53 (1) : 44–52.
Madson, D. M., Magstadt, D. R., Arruda, P. H., Hoang, H., Sun, D., and Bower. L. P. (2014). Pathogenesis of Porcine Epidemic Diarrhoea Virus Isolate (US/Iowa/18984/ 2013) In 3-Week-Old Weaned Pigs. Veterinary Microbiology. 174(1-2):60-68.
Marthaler, D., Jiang, Y., Otterson, T., Goyal, S., Rossow, K., and Collins, J. (2013). Complete Genome Sequence of Porcine Epidemic Diarrhea Virus Strain USA/Colorado/2013 from The United States. Genome Announcements. 1(4) :E00555-13.
Niederwerder, M. C., Nietfeld, J. C., Bai, J., Peddireddi, L., Breazeale, B., Anderson, J., and Hesse, R. A. (2016). Tissue Localization, Shedding, Virus Carriage, Antibody Response, and Aerosol Transmission of Porcine Epidemic Diarrhea Virus Following Inoculation of 4‐Week‐Old Feeder Pigs. Journal Of Veterinary Diagnostic Investigation. 28 (6) :671–678.
OIE. (2020). World Animal Health Information System (WAHIS): Jul-Dec. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/
Opressnig, T. (2016). Porcine Epidemic Diarrhea (PED) in Europe and Strategies to Control Outbreaks. The Japanese Journal Of Veterinary Research. 64 (1) : 35–38.
Pan, Y., Tian, X., Li, W., Zhou, Q., Wang, D., Bi, Y., Chen, F., and Song, Y. (2012). Isolation and Characterization of A Variant Porcine Epidemic Diarrhea Virus in China. Virology Journal. 9: 195–204.
Park, C. K., Lee, K. and K., Lee, C. (2011). PED Past, Present, and Future. Asian Pig Veterinary Society Congress. 19–20.
Park, J. E., and Shin, H. J. (2014). Porcine Epidemic Diarrhoea Virus Infects and Replicates in Porcine Alveolar Macrophages. Virus Research. 191:143–152.
Pizzurro, F., Cito, F., Zaccaria, G., Spedicato, M., Cerella, A., Orsini, M., Forzan, M., D’Alterio, N., Lorusso, A., and Marcacci, M. (2018). Outbreak of Porcine Epidemic Diarrhoea Virus (PEDV) in Abruzzi Region, Central-Italy. Veterinary Medicine and Science. 4 (2) : 73-79.
Puranaveja, S., Poolperm, P., Lertwatcharasarakul, P., Kesdaengsakonwut, S., Boonsoongnern, A., Urairong, K., Kitikoon, P., Choojai, P., Kedkovid, R., Teankum, K., Thanawongnuwech, R. (2009). Chinese-like strain of porcine epidemic diarrhea virus, Thailand. Emerg Infect Dis. 15:1112–1115.
Qian, S., Zhang, W., Jia, X., Sun, Z., Zhang, Y., Xiao, Y., and Li, Z. (2019). Isolation and Identification of Porcine Epidemic Diarrhea Virus and Its Effect on Host Natural Immune Response. Frontier in Microbiology. 10: 2272.
Ren, X., Suo, S., and Jang, Y. S. (2011). Development of A Porcine Epidemic Diarrhea Virus M Protein-Based ELISA for Virus Detection. Biotechnology Letters. 33 (2) :215–220.
Sasaki, Y., Alvarez, J., Sekiguchi, S., Sueyoshi, M., Otake, S., and Perez, A. (2016). Epidemiological Factors Associated to Spread of Porcine Epidemic Diarrhea in Japan. Preventive Veterinary Medicine. 123:161–167.
Sato, T., Takeyama, N., Katsumata, A., Tuchiya, K., Kodama, T., and Kusanagi, K. (2011).
Mutations in the Spike Gene of Porcine Epidemic Diarrhea Virus Associated
With Growth Adaptation in Vitro and Attenuation of Virulence In Vivo. Virus
Genes. 43 (1) :72–78.
Schumacher, L. L., Cochrane, R. A., Huss, A. R., Gebhardt, J. T., Woodworth, J. C., Stark, C. R., Jones, C. K., Bai, J., Main, R. G., Chen, Q., Zhang, J., Gauger, P. C., Derouchey, J. M,. Goodband, R. D., Tokach, M. D., and Dritz, S. S. (2018). Feed Batch Sequencing to Decrease the Risk of Porcine Epidemic Diarrhea Virus (PEDV) Cross-Contamination During Feed Manufacturing. Journal of Animal Science. 96 (11) :4562-4570.
Schumacher, L. L., Huss, A. R., Cochrane, R. A., Stark, C. R., Woodworth, J. C., Bai, J., Poulsen, E. G., Chen, Q., Main, R. G., Zhang, J., Gauger, P. C., Ramirez, A., Derscheid, R. J., Magstadt, D. M., Dritz, S. S., and Jones, C. K. (2017). Characterizing the Rapid Spread of Porcine Epidemic Diarrhea Virus (PEDV) Through An Animal Food Manufacturing Facility. Plos One. 12 (11) : E0187309
Schwartz, K., Henry, S., Tokach, L., Potter, M., Davidson, D., and Egnor, C. (2014). Exposing Sows to PEDV to Build Herd Immunity [Internet]. [Cited Agust 11, 2022] Available From :Http://Nationalhogfarmer.Com/Business/Exposing-Sows-Pedv-Build-Herd-Immunity.
Song, D., and Park, B. (2012). Porcine Epidemic Diarrhoea Virus: A Comprehensive Review of Molecular Epidemiology, Diagnosis, and Vaccines. Virus Genes. 44 (2) : 167–175.
Song, D., Moon, H., and Kang, B. (2015). Porcine Epidemic Diarrhea: A Review of Current Epidemiology and Available Vaccines. Clinical and Experimental Vaccine Research. 4 (2) :166–176.
Sozzi, E., Luppi, A., Lelli, D., Martin, A. M., Canelli, E., and Brocchi, E. (2010). Comparison of Enzyme-Linked Immunosorbent Assay and RT-PCR for the Detection of Porcine Epidemic Diarrhoea Virus. Research in Veterinary Science. 88 (1) :166–168.
Stevenson, G. W., Hoang, H., Schwartz, K. J., Burrough, E. B., Sun, D., Madson, D., Cooper, V. L., Pillatzki, A., Gauger, P., and Schmitt, B. J. (2013). Emergence of Porcine Epidemic Diarrhea Virus in The United States: Clinical Signs, Lesions, and Viral Genomic Sequences. Journal of Veterinary Diagnostic Investigation. 25 (5) :649–654.
Sun, R. Q., Cai, R. J., Chen, Y. Q., Liang, P. S., Chen, D. K., and Song, C. X. (2012). Outbreak of Porcine Epidemic Diarrhea in Suckling Piglets, China. Emerging Infectious Diseases. 18 (1) :161–163.
Sun, R., Leng, Z., Dekun, C., and Song, C. (2014). Multiple Factors Contribute to Persistent Porcine Epidemic Diarrhoea Infection in the Field: An Investigation on Porcine Epidemic Diarrhoea Repeated Outbreaks in the Same Herd. Journal of Animal and Veterinary Advances. 13 (6) :410–415.
Theuns, S., Conceição-Neto, N., Christiaens, I., Zeller, M., Desmarets, L. M., and Roukaerts, I. D. Complete Genome Sequence of A Porcine Epidemic Diarrhea Virus From A Novel Outbreak In Belgium, January 2015. Genome announcements.3 (3) :E00506-15.
Tian, Y., Yu, Z., and Cheng, K. (2013). Molecular Characterization and Phylogenetic Analysis of New Variants of the Porcine Epidemic Diarrhea Virus in Gansu, China in 2012. Viruses. 5 (8) :1991–2004.
Turlewicz-Podbielska, H., and Pomorska-Mól, M. (2021). Porcine Coronaviruses: Overview of the State of the Art. Virol. Sin. 36, 833–851.
Wang, J., Zhao, P., and Guo, L. (2013). Porcine Epidemic Diarrhea Virus Variants With High Pathogenicity, China. Emerging Infectious Diseases. 19 (12) : 2048–2049.
Won, H., Lim, J., Noh, Y. H., Yoon, I., and Yoo, H. S. (2020). Efficacy of porcine epidemic diarrhea vaccines: A systematic review and meta-analysis. Vaccines, 8(4), 642.
Woo, P. C. Y., Huang, Yi., Lau, K. P. L., and Yuen, K. W. (2010). Corona Virus Genomics and Bioinformatics Analysis.Viruses. 2 (8) :1804-1820.
Woo, P., Lau, S., Lam, C., Lau, C., Tsang, A., and Lau, J. (2012). Discovery of Seven Novel Mammalian and Avian Coronaviruses in Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alpacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus. Journal of Virology. 32 (7) :3995–4008
Xu, X., Zhang, H., Zhang, Q., Huang, Y., Dong, J., and Liang, Y. (2013). Porcine Epidemic Diarrhea Virus N Protein Prolongs S-Phase Cell Cycle, Induces Endoplasmic Reticulum Stress, And Up-Regulates Interleukin-8 Expression. Veterinary Microbiology. 164 (3-4) :212–221.
Zhang, Y., Chen, Y., Zhou, J., Wang, X., Ma, L., Li, J., Yang, L., Yuan, H., Pang, D., and Ouyang, H. (2022). Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions. Viruses, 14(11), 2434.
Published
2026-10-15
How to Cite
Rinca, K., Cahyadi Putra, I., Widyasanti, N. W., Mandala, A., & Putri, M. F. (2026). Review : Porcine Epidemic Diarrhea pada Anak Babi. Jurnal Veteriner Nusantara, 9(2), 105-117. https://doi.org/10.35508/jvn.v9i2.30705
Section
Review
Copyright (c) 2026 Korbinianus Feribertus Rinca, I Putu Cahyadi Putra, Ni Wayan Helpina Widyasanti, Aletha Yuliana Mandala, Mariana Febrilianti Resilinda Putri
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