Perbandingan Onset, Durasi Anestesi Dan Masa Pemulihan Dari Pemberian Kombinasi Anestesi Acepromasin-Propofol-Ketamin Dan Midazolam-Propofol-Ketamin Pada Anjing Lokal
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Dalmasia Trisna Dhiu(1*)
Universitas Nusa Cendana
-
Tri Utami(2)
Universitas Nusa Cendana
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Nemay Anggadewi Ndaong(3)
Universitas Nusa Cendana
(*) Corresponding Author
Keywords:
onset, duration, anaesthesia
Abstract
This study aims to determine and compare the onset, duration and recovery period between the use of a combination of Acepromazine-Propofol-Ketamine and a combination of Midazolam-Propofol-Ketamine as an anesthetic drug in local dogs. Dogs are grouped into two treatment groups consisting of 3 local male dogs. Before the anesthetic agent was injected, each group was given premedication atropine sulfate at a dose of 0.02 mg / kg BW IM and 10 minutes later an induction of anesthesia was given. In treatment group 1, acepromazine (0.2 mg / kg BB) IV was administered, propofol (4 mg / kg BB) IV, and ketamine (4 mg / kg BW) IV. Group II was given anesthesia midazolam (0.2 mg / kg BB) IV, propofol (4 mg / kg BW) IV, and ketamine (4 mg / kg BW) IV. Observation and measurement of the onset, duration and recovery period were carried out after the animal was induced with an anesthetic agent. The results of the study obtained the following data: KI group produced an average onset of 94 seconds, duration of 30 minutes and recovery period of 30.33 minutes. KII produces an onset of 45.33 seconds, duration of 17.66 minutes and recovery time of 16 minutes. Based on the results of the study it can be concluded that the combination of midazolam-propofol-ketamine has a faster onset, duration and recovery period compared to the combination of acepromasizine-propofol-ketamine in local male dog.
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References
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Christopher., Lordan, A., Pizzi, L., dan Thoma, Brandi. 2013, US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis, Am Health Drug Benefit. 6(4):171-175.
Clarke, K.W., Trim, C.M. dan Hall, L.W. 2014, Veterinary Anaesthesia, 11th ed. London: Saunders Elsevier.
Cullen, L.K. 1997, Lecture Notes on Veterinary Anesthesia, Murdoch University, Australia.
Dehkordi, M.E., Razavi, S.S. dan Momenzadeh S. 2010, A Comparison between Sedative Effect of Propofol-Fentanyl and Propofol-Midazolam Combinations in Microlaryngeal Surgerie, Shahid Beheshti University of Medical Sciences Iran Iranian, Journal of Pharmaceutical Research, 11 (1): 287-294
Dharmajono. 2003, P3K Anjing dan Kucing, Jakarta: Penebar Swadaya.
Dharmayudha, A.A.G.O. dan Gorda, I.W. 2012, Perbandingan Anestesi Xylazin-Ketamin Hidroklorida dengan Anestesi Tiletamin-Zolazepam terhadap Frekuensi Denyut Jantung dan Pulsus Anjing Lokal. Buletin Veteriner Udayana: 4(1):9-15
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Fathoni, F. 2008, ‘Studi Kadar Serum Glutamat Piruvat Transminase, Serum Glutamat Oksaloasetat Transminase dan Total Protein pada Serum Darah Anjing Kampung (Canis Familiaris) Usia 3 dan 6 Bulan’, Skripsi, SKH., Institut Pertanian Bogor, Bogor.
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Kaban, I.K.B. 2013, Pengaruh Acepromazine sebagai Preanestesi dan Sebagai Campuran Anestetika Ketamin terhadap Onset dan Durasi Anestesi pada Kucing, Skripsi SKH., Fakultas Kedokteran Hewan. Universitas Gadjah Mada, Yogyakarta.
Kanto, J. dan Allonen, H. 1983, Pharmacokinetics and the Sedative Effect of Midazolam, Int J Clin Pharmacol Ther Toxicol, Sep;21(9):460-3
Katzung, BG. 1998, Farmakologi Dasar dan Klinik, 6th ed, EGC, Jakarta.
Lumb dan Jones. 1984, Veterinary Anasthesia, 2nd ed, Blackwell Publishing, USA.
Lumb, M.V. dan Jones, E.W. 2007, Veterinary Anesthesia and Analgesia, 4th ed, Blackwell Publishing, USA.
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McKelvey, D. dan Hollingshead, K.W. 2003, Veterinary Anesthesia and Analgesia, 3rd ed, Mosby, USA.
Miller, M.E. 1993, Anatomi of the Dog, W. B. Saunder Company, Philadelphia London New York St. Louis Sydney Toronto.
Muslihun. 1954, Manusia dan Hewan Piaraan, 1st ed, PT. Pembangunan, Jakarta.
Nain, V., Kumar, A. , Jit , S., Sukhbir, S. dan Peshin, P. K. 2010, Evaluation of Aceromazine, Diazepam and Midazolam as a Sedatives in Buffalo Calves, Indian Journal of Veterinary Research, 19 (2):22-36
Nugraha, N.N.K. 2007, ‘Gambaran Darah Anjing Kampung Jantan (Canis Familiaris) Umur 3 sampai 7 Bulan’, Skripsi. SKH, Institut Pertanian Bogor, Bogor.
Plumb, D.C. 2005, Veterinary Drug Handbook, 5th ed, Blackwell Publishing, USA.
. 2008, Veterinary Drug Handbook. 6th ed, Blackwell Publishing, USA.
Quandt, J. 2013, Analgesia, Anesthesia, and Chemical Restraint in the Emergent Small Animal Patient, Veterinary of North America Small Animal Practice, 43(4): 41-53.
Sardjana, I.K.W. 2003, Penggunaan Zoletil dan Ketamin untuk Anestesia pada Felidae, Berk. Penel. Hayati, 9:37-40.
Sardjana, I.K.W. dan D. Kusumawati. 2004, Anestesi Veterinary, 1st ed, Gadjah Mada University Press, Yogyakarta.
Sinatra, R.S., Jahra, J.S. dan Watkings-Pitchford, J.M. 2011, The Essence Of Analgesia and Analgesics, Cambridge University Press, New York.
Smith, B.J. dan Mangkoewidjojo. 1988, Pemeliharaan, Pembiakan dan Penggunaan Hewan Percobaan di Daerah Tropis, Universitas Indonesia Press, Jakarta.
Steve, C, Haskins, John, P. Farer, T.B. 1986, Xylazine and Ketamine in Dogs, Am. J. Vet. Res: 636-64
Stoelting, Hiller. 1999, Pharmacologi and Physiologi in Anesthesic Practice, 1st Ed. Philadelphia: William and Wilkins; 2006: 514-54
Sudisma, I.G.N. 2011, ‘Keterpilihan dan Kebakuan Dosis Anestesi Ketamin dan Propofol Menggunakan Metode Gravimetrik pada Anjing’, Tesis, MSc., Institut Pertanian Bogor, Bogor.
Sudisma, I.G.N., Widodo, S., Sajuthi, D. dan Soehartono, H. 2012, Anestesi Infus Gravimetrik Ketamin dan Propofol pada Anjing, Jurnal Veteriner, 13(2): 189-198
Swarayana, I.M.I. 2015,’Pemeliharaan Status Teranestesi dengan Kombinasi Xilasin Ketamin secara Subkutan pada Anjing’, Tesis, MSc., Universitas Udayana, Bali.
Tranquili, W. J., Thurmon, J. L. dan Grim, K. A. 2007, Veterinary Anesthesia and Analgesia, 4 th ed, Ames, Blackwell.
Untung, O. 1997, Merawat dan Memelihara Anjing, Ed, 6th ed, PT. Penebar Swadaya, Jakarta.
Welsh, L. 2009, Anaesthesia for Veterinary Nurses, 2nd ed, Blackwell Publishing Ltd, USA.
Winarto, D. 2009, ‘Pengaruh Pemberian Ketamin Dosis Induksi dan Analgesi terhadap Kapasitas Fagositosis Makrofag Intraperitoneal Mencit Balb/C yang Terpapar Lipopolisakarida’, Tesis, MSc., Fakultas Kedokteran. Universitas Diponegoro, Semarang.
Yudaniayanti., Triaksoro, I. S., Nusdianto, G., dan Djoko. 2012, Analisis Gas darah pada kucing yang mengalami laparohisteretomi dengan anestesi xylasin-ketamin dan xylasin-propofol, J Vet Udayana, 12(1):13-18.
Zunilda, D. dan Elysabeth. 2007, Anestetik Umum, 5th ed, Jakarta.
Andriastuti, M., Kartika, D. dan WR, A.A. 2016, Perbandingan Efektivitas dan Keamanan Kombinasi Ketamin/Midazolam Dibandingkan Ketamin Tunggal sebagai Sedasi pada Anak, Sari Pediatri, 18(3).
Becker, M. dan Beglinger, R. 1982, Ketamine and Myocardial Contractility in the Cat. Veterinary Anaesthesia and Analgesia, 10(1):232-238.
Bower, J. dan Youngs, D. 1990, The Health of Your Dog, The Crowood Press. London.
Brearley, J. C.,Kellagher, R. E. B. dan Hall, L.W. 1998, Propofol Anaesthesia in Cats, Journal Of Animal Practice, 28(5)
Bryant, S. 2010, Anesthesia for Veterinary Technicians, 4th Ed. Wiley-Blackwell Publishing.USA.
Christopher., Lordan, A., Pizzi, L., dan Thoma, Brandi. 2013, US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis, Am Health Drug Benefit. 6(4):171-175.
Clarke, K.W., Trim, C.M. dan Hall, L.W. 2014, Veterinary Anaesthesia, 11th ed. London: Saunders Elsevier.
Cullen, L.K. 1997, Lecture Notes on Veterinary Anesthesia, Murdoch University, Australia.
Dehkordi, M.E., Razavi, S.S. dan Momenzadeh S. 2010, A Comparison between Sedative Effect of Propofol-Fentanyl and Propofol-Midazolam Combinations in Microlaryngeal Surgerie, Shahid Beheshti University of Medical Sciences Iran Iranian, Journal of Pharmaceutical Research, 11 (1): 287-294
Dharmajono. 2003, P3K Anjing dan Kucing, Jakarta: Penebar Swadaya.
Dharmayudha, A.A.G.O. dan Gorda, I.W. 2012, Perbandingan Anestesi Xylazin-Ketamin Hidroklorida dengan Anestesi Tiletamin-Zolazepam terhadap Frekuensi Denyut Jantung dan Pulsus Anjing Lokal. Buletin Veteriner Udayana: 4(1):9-15
Fadhli, C., Syafruddin., Sayuti, A., Asmilia, N., Erwin., dan Frengky. 2016, Perbandingan Onset dan Sedasi Ketamin-Xilazin dan Propofol pada Anjing Jantan Lokal (Canis Familiaris), Jurnal Medika Veterinaria, 10(2):94-96.
Fathoni, F. 2008, ‘Studi Kadar Serum Glutamat Piruvat Transminase, Serum Glutamat Oksaloasetat Transminase dan Total Protein pada Serum Darah Anjing Kampung (Canis Familiaris) Usia 3 dan 6 Bulan’, Skripsi, SKH., Institut Pertanian Bogor, Bogor.
Ganiswara, S. G. 2009, Farmakologi dan Terapi, Balai Penerbit FKUI, Jakarta.
Garcia, P. S., Scott, E. Kolesky., dan Andrew, J. 2010, General Anesthetic Actions on GABA Receptors, Bentham Science Publisher, USA.
Hall, L. W., dan Clark, K. W. 1983, Veterinary Anastesia. 8th ed.The English Language Book Society and Baillere Tindall, London.
Hall, L.W. dan Chambers, J.P. 1987, A Clinical Trial of Propofol Infusion Anaesthesia in Dogs, Journal of Small Animal Practice, 28: 623–637.
Hall, L.W., Clarke, K.W., dan Trim, C.M. 2001, Veterinary Anaesthesia 10th ed, W.B. Saunder, London.
Hartaningsih, N., Dharma, D.M.N. dan Rudyanto, M.D. 1999, Anjing Bali, Pemuliaan dan Pelestaria, Ist ed, Penerbit Kanisius, Yogyakarta.
Hartuti, S.H., Mulyadi, A., dan Triva, M. 2014, Kajian Kesejahteraan Kucing yang Dipelihara pada Beberapa Pet Shop di Wilayah Bekasi Jawa Barat, Jurnal Medika Veterinaria, 8(1):37-42
Hilbery, A.D.R., Waterman, A.E. dan Brouwer, G.J. 1992, Manual of Anaesthesia for Small Animals Practise, 3th ed, British Small Animal Veterinary Association.
Itvatia, A. 2006, ‘Pet and Flower House’, Skripsi SKH, Universitas Diponegoro, Semarang.
Jones, L. M., N. H, Booth., dan L. E. McDonald. 1997, Veterinary Pharmacology and Therapeutics, Oxford and IBH, New Delhi.
Kaban, I.K.B. 2013, Pengaruh Acepromazine sebagai Preanestesi dan Sebagai Campuran Anestetika Ketamin terhadap Onset dan Durasi Anestesi pada Kucing, Skripsi SKH., Fakultas Kedokteran Hewan. Universitas Gadjah Mada, Yogyakarta.
Kanto, J. dan Allonen, H. 1983, Pharmacokinetics and the Sedative Effect of Midazolam, Int J Clin Pharmacol Ther Toxicol, Sep;21(9):460-3
Katzung, BG. 1998, Farmakologi Dasar dan Klinik, 6th ed, EGC, Jakarta.
Lumb dan Jones. 1984, Veterinary Anasthesia, 2nd ed, Blackwell Publishing, USA.
Lumb, M.V. dan Jones, E.W. 2007, Veterinary Anesthesia and Analgesia, 4th ed, Blackwell Publishing, USA.
Lumb, M.V. dan Jones, E.W. 2015, Veterinary Anesthesia and Analgesia, 5th ed, Blackwell Publishing, USA.
McKelvey, D. dan Hollingshead, K.W. 2003, Veterinary Anesthesia and Analgesia, 3rd ed, Mosby, USA.
Miller, M.E. 1993, Anatomi of the Dog, W. B. Saunder Company, Philadelphia London New York St. Louis Sydney Toronto.
Muslihun. 1954, Manusia dan Hewan Piaraan, 1st ed, PT. Pembangunan, Jakarta.
Nain, V., Kumar, A. , Jit , S., Sukhbir, S. dan Peshin, P. K. 2010, Evaluation of Aceromazine, Diazepam and Midazolam as a Sedatives in Buffalo Calves, Indian Journal of Veterinary Research, 19 (2):22-36
Nugraha, N.N.K. 2007, ‘Gambaran Darah Anjing Kampung Jantan (Canis Familiaris) Umur 3 sampai 7 Bulan’, Skripsi. SKH, Institut Pertanian Bogor, Bogor.
Plumb, D.C. 2005, Veterinary Drug Handbook, 5th ed, Blackwell Publishing, USA.
. 2008, Veterinary Drug Handbook. 6th ed, Blackwell Publishing, USA.
Quandt, J. 2013, Analgesia, Anesthesia, and Chemical Restraint in the Emergent Small Animal Patient, Veterinary of North America Small Animal Practice, 43(4): 41-53.
Sardjana, I.K.W. 2003, Penggunaan Zoletil dan Ketamin untuk Anestesia pada Felidae, Berk. Penel. Hayati, 9:37-40.
Sardjana, I.K.W. dan D. Kusumawati. 2004, Anestesi Veterinary, 1st ed, Gadjah Mada University Press, Yogyakarta.
Sinatra, R.S., Jahra, J.S. dan Watkings-Pitchford, J.M. 2011, The Essence Of Analgesia and Analgesics, Cambridge University Press, New York.
Smith, B.J. dan Mangkoewidjojo. 1988, Pemeliharaan, Pembiakan dan Penggunaan Hewan Percobaan di Daerah Tropis, Universitas Indonesia Press, Jakarta.
Steve, C, Haskins, John, P. Farer, T.B. 1986, Xylazine and Ketamine in Dogs, Am. J. Vet. Res: 636-64
Stoelting, Hiller. 1999, Pharmacologi and Physiologi in Anesthesic Practice, 1st Ed. Philadelphia: William and Wilkins; 2006: 514-54
Sudisma, I.G.N. 2011, ‘Keterpilihan dan Kebakuan Dosis Anestesi Ketamin dan Propofol Menggunakan Metode Gravimetrik pada Anjing’, Tesis, MSc., Institut Pertanian Bogor, Bogor.
Sudisma, I.G.N., Widodo, S., Sajuthi, D. dan Soehartono, H. 2012, Anestesi Infus Gravimetrik Ketamin dan Propofol pada Anjing, Jurnal Veteriner, 13(2): 189-198
Swarayana, I.M.I. 2015,’Pemeliharaan Status Teranestesi dengan Kombinasi Xilasin Ketamin secara Subkutan pada Anjing’, Tesis, MSc., Universitas Udayana, Bali.
Tranquili, W. J., Thurmon, J. L. dan Grim, K. A. 2007, Veterinary Anesthesia and Analgesia, 4 th ed, Ames, Blackwell.
Untung, O. 1997, Merawat dan Memelihara Anjing, Ed, 6th ed, PT. Penebar Swadaya, Jakarta.
Welsh, L. 2009, Anaesthesia for Veterinary Nurses, 2nd ed, Blackwell Publishing Ltd, USA.
Winarto, D. 2009, ‘Pengaruh Pemberian Ketamin Dosis Induksi dan Analgesi terhadap Kapasitas Fagositosis Makrofag Intraperitoneal Mencit Balb/C yang Terpapar Lipopolisakarida’, Tesis, MSc., Fakultas Kedokteran. Universitas Diponegoro, Semarang.
Yudaniayanti., Triaksoro, I. S., Nusdianto, G., dan Djoko. 2012, Analisis Gas darah pada kucing yang mengalami laparohisteretomi dengan anestesi xylasin-ketamin dan xylasin-propofol, J Vet Udayana, 12(1):13-18.
Zunilda, D. dan Elysabeth. 2007, Anestetik Umum, 5th ed, Jakarta.
Published
2021-02-19
How to Cite
Dhiu, D., Utami, T., & Ndaong, N. (2021). Perbandingan Onset, Durasi Anestesi Dan Masa Pemulihan Dari Pemberian Kombinasi Anestesi Acepromasin-Propofol-Ketamin Dan Midazolam-Propofol-Ketamin Pada Anjing Lokal. Jurnal Veteriner Nusantara, 4(1), 10. https://doi.org/10.35508/jvn.v4i1.6044
Section
Articles
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