PERBANDINGAN KADAR GLUTATION TEREDUKSI (GSH) PADA KEHAMILAN NORMAL DAN KEHAMILAN PREEKLAMPSIA DI RSUD. PROF. DR. W.Z. JOHANNES KUPANG
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Keywords

Kehamilan, Preeklampsia, GSH

How to Cite

Ly, E., Amat, A., & Wungouw, H. (2019). PERBANDINGAN KADAR GLUTATION TEREDUKSI (GSH) PADA KEHAMILAN NORMAL DAN KEHAMILAN PREEKLAMPSIA DI RSUD. PROF. DR. W.Z. JOHANNES KUPANG. Cendana Medical Journal (CMJ), 7(1), 132-138. Retrieved from https://ejurnal.undana.ac.id/CMJ/article/view/1497

Abstract

Angka Kematian Ibu di Indonesia mencapai 305 per 100.000KH dengan 25% dintaranya disebabkan oleh preeklampsia. Salah satu teori penyebab preeklampsia adalah stres oksdatif yang menyebabkan kerusakan sel endotel pembuluh darah. Stres oksidatif ditandai dengan peningkatan radikal bebas dan penurunan antioksidan. Glutation tereduksi (GSH) merupakan salah satu antioksidan endogen tubuh. Tujuan penelitian ini untuk mengetahui perbandingan kadar GSH pada kehamilan normal dan kehamilan preeklampsia  di RSUD Prof. Dr. W.Z. Johannes Kupang Tahun 2018. Metode penelitian yang digunakan adalah Observasional Analitik dengan pendekatan cross sectional. Teknik sampling menggunakan teknik consecutive sampling dengan hasil 30 sampel darah vena pada kehamilan normal dan 30 sampel darah vena pada kehamilan preeklampsia. Kadar GSH pada sampel darah diuji menggunakan Spektrofotometri. Hasil rerata dan median kadar GSH pada kehamilan preeklampsia lebih rendah dibandingan rerata dan median kadar GSH pada kehamilan normal. Pada kehamilan preeklampsia rerata kadar GSH yaitu 1,875 nmol/ml dengan median 1,2 nmol/ml lebih rendah dibandingkan pada kehamilan normal rerata kadar GSH yaitu 3,612 nmol/ml dengan median 1,8  nmol/ml Berdasarkan uji Mann Whitney didapatkan nilai p= 0,010 (<0,05) yang berarti terdapat perbedaan kadar GSH yang signifikan pada kehamilan normal dibandingkan dengan kehamilan preeklampsia. Kesimpulan dari penelitian ini kadar GSH pada kehamilan normal lebih tinggi daripada kehamilan preeklampsia.

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