Efek Penggunaan Terapi Plasma Konvalesen pada Proses Pengobatan Pasien COVID-19
-
Rambu Bangi Lokat(1*)
Universitas Nusa Cendana
-
Magdarita Riwu(2)
Universitas Nusa Cendana
-
Efrisca M. Br. Damanik(3)
Universitas Nusa Cendana
-
Elisabeth Levina Sari Setianingrum(4)
Universitas Nusa Cendana
(*) Corresponding Author
Kata Kunci:
Plasma konvalesen, pasien Covid-19, efek terapi
Abstrak
Latar Belakang : Tingginya angka kejadian Covid-19 di Indonesia maupun dunia, membuat pemerintah dan segala institusi kesehatan terus bergerak untuk mencari pengobatan Covid-19. Pengobatan Covid-19 sampai saat ini masih terus diupayakan untuk memberikan terapi yang terbaik bagi pasien Covid-19, dalam upaya tersebut diberikan juga salah satu terapi tambahan yaitu terapi plasma konvalesen untuk pasien Covid-19. Kemanjuran dan keamanan penggunaan plasma konvalesen saat ini masih kurang bukti pasti, sehingga perlunya study literature untuk melihat hasil penelitian yang sudah ada untuk ditelaah.
Tujuan Penelitian : Mengetahui efek apa saja yang dihasilkan dari penggunaan terapi plasma konvalesen pada proses pengobatan pasien Covid-19.
Metode : Jenis penelitian ini merupakan penelitian literature review yang menggunakan data sekunder. Pencarian literature melalui database PubMed dan Google Scholar yang kemudian dilakukan seleksi sesuai kriteria inklusi yang ditetapkan untuk dilakukan review. Data hasil pencarian didapatkan 26 jurnal yang sesuai dengan topik penelitian yang terbit dalam tahun 2020-2021. Semua hasil penelitian yang terdapat dalam jurnal disusun dalam tabel ekstraksi data. Hasil literature review dianalisis menggunakan topik yang sesuai dengan tujuan literature review berdasarkan temuan dari jurnal.
Hasil : Hasil review dari 26 jurnal dalam penggunaan plasma konvalesen, didapatkan 16 jurnal menunjukkan efek yang positif dalam penggunaan plasma konvalesen dan terdapat juga penggunaan plasma konvalesen yang memberi efek negatif dalam 10 jurnal hasil review.
Kesimpulan : Literature review yang dilakukan pada 26 jurnal dalam penelitian ini dapat diambil kesimpulan bahwa efek yang terjadi pada penggunaan terapi plasma konvalesen bisa berupa efek positif yaitu adanya perbaikan gejala klinis pasien dan efek negatif berupa efek samping terapi dan kurangnya peranan terapi plasma konvalesen.
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Referensi
1. WHO. Naming the coronavirus disease (COVID-19) and the virus that causes it Tersedia : https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it, diakses tanggal 12 Mei 2021
2. WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data. Tersedia : https://covid19.who.int/, diakses tanggal 6 Juni 2021
3. COVID-19 NTT Tersedia : http://covid19.nttprov.go.id/home, diakses tanggal 5 Juni 2021
4. Burhan E, Susanto AD, Nasution SA, Ginanjar E, Pitoyo CW, Susilo A, et al. PEDOMAN TATALAKSANA COVID-19 Edisi 3 TIM EDITOR Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi dan Terap. 2020. 88–89 p.
5. Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA - J Am Med Assoc. 2020;323(16):1582–9.
6. Li L, Zhang W, Hu Y, Tong X, Zheng S, Yang J, et al. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients with Severe and Life-threatening COVID-19: A Randomized Clinical Trial. JAMA - J Am Med Assoc. 2020 Aug 4;324(5):460–70.
7. Kementerian Kesehatan Republik Indonesia. Terapi Plasma Konvalesen, Harapan Baru Tangani COVID-19. Tersedia : https://www.kemkes.go.id/article/view/20090900001/terapi-plasma-konvalesen-harapan-baru-tangani-covid-19.html, diakses tanggal 15 Mei 2021
8. Sastroasmoro S, Ismael S. Dasar-dasar metode penelitian klinis. 2nd ed. Jakarta: CV Sagung Seto; 2002.
9. Ahn JY, Sohn Y, Lee SH, Cho Y, Hyun JH, Baek YJ, et al. Use of convalescent plasma therapy in two covid-19 patients with acute respiratory distress syndrome in Korea. J Korean Med Sci. 2020;35(14):2–9.
10. Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A. 2020;117(17):9490–6.
11. Ye M, Fu D, Ren Y, Wang F, Wang D, Zhang F, et al. Treatment with convalescent plasma for COVID ‐ 19 patients in Wuhan , China.
12. Mohammed H, Hama-ali HH, Nasraddin S, Muhammad K, Amin K, Othman S, et al. Severe refractory COVID-19 patients responding to convalescent plasma ; A case series. Ann Med Surg. Tersedia : https://doi.org/10.1016/j.amsu.2020.06.018
13. Huang S, Shen C, Xia C, Huang X, Fu Y, Tian L. A Retrospective Study on the Effects of Convalescent Plasma Therapy in 24 Patients Diagnosed with COVID-19 Pneumonia in February and March 2020 at 2 Centers in. 2020;1–9.
14. Joyner MJ, Marks P, Casadevall A, Joyner MJ, Wright RS, Fairweather D, et al. Early safety indicators of COVID-19 convalescent plasma in 5000 patients Early safety indicators of COVID-19 convalescent plasma in 5000 patients. 2020;130(9):4791–7.
15. Bar KJ, Siegel DL, Tebas P, Bar KJ, Shaw PA, Choi GH, et al. A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia. 2021;131(24):2–10.
16. Ibrahim D, Dulipsingh L, Zapatka L, Hussain, Eadie R, Crowell R, et al. Factors Associated with Good Patient Outcomes Following Convalescent Plasma in COVID-19 : A Prospective Phase II Clinical Trial. Infect Dis Ther. Tersedia : https://doi.org/10.1007/s40121-020-00341-2
17. Hu X, Hu C, Jiang D, Zuo Q, Li Y, Wang Y, et al. Effectiveness of Convalescent Plasma Therapy for COVID-19 Patients in. 2020;(December):1–12.
18. Gemİcİ A, Bİlgen H, Erdoğan C, Kansu A, Olmuşçelİk O. A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma. 2020;1781–5.
19. Allahyari A, Seddigh-Shamsi M, Mahmoudi M, Jamehdar SA, Amini M, Mozdourian M, et al. Efficacy and safety of convalescent plasma therapy in severe COVID-19 patients with acute respiratory distress syndrome. 2020;(January).
20. Avendaño-solá C, Duarte RF, Group C-S, Avendaño-solá C, Ramos-martínez A, Muñez-rubio E, et al. convalescent plasma in patients hospitalized with COVID-19 pneumonia A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumonia. 2021;131(20).
21. Avendaño-Solà C, Ramos-Martínez A, Muñez-Rubio E, Ruiz-Antorán B, Molina RM de, Torres F, et al. Convalescent Plasma for COVID-19 : A multicenter , randomized clinical trial Authors : Affiliations : 2020;
22. Li L, Tong X, Chen H, He R, Lv Q, Yang R, et al. Original research. 2020;1–8.
23. O’Donnell MR, Grinsztejn B, Cummings MJ, Justman JE, Lamb MR, Eckhardt CM, et al. A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. J Clin Invest. 2021;131(13):1–9.
24. Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T. Convalescent plasma in the management of moderate covid-19 in adults in India : open label phase II multicentre randomised controlled trial ( PLACID Trial ). :1–10.
25. Zhang B, Liu S, Tan T, Huang W, Dong Y, Chen L. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- research that is available on the COVID-19 resource centre - including this Treatment With Convalescent Plasma. 2020;(January).
26. Dai W, Wu J, Li T, Shen J, Pang R, Luo T, et al. Clinical outcomes for COVID ‐ 19 patients with diabetes mellitus treated with convalescent plasma transfusion in Wuhan , China.
27. Kurtz P, Righy C, Gadelha M, Bozza FA, Higa LM, Castilho L, et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19 : An Observational Study. 2021;8(January):1–9.
28. Rogers R, Shehadeh F, Mylona EK, Rich J, Neill M, Touzard-romo F, et al. Convalescent Plasma for Patients With Severe Coronavirus Disease 2019 ( COVID-19 ): A Matched Cohort Study. 2021;2019.
29. AlQahtani M, Abdulrahman A, Almadani A, Alali SY, Al Zamrooni AM, Hejab AH, et al. Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease. Sci Rep [Internet]. 2021;11(1):1–8. Tersedia : https://doi.org/10.1038/s41598-021-89444-5
30. Korley FK, Durkalski-Mauldin V, Yeatts SD, Schulman K, Davenport RD, Dumont LJ, et al. Early Convalescent Plasma for High-Risk Outpatients with Covid-19. N Engl J Med. 2021;385(21):1951–60.
31. Siminovich V, Pratx burgos L, Scibona P, Beruto M, Vallone M, Vazques C, et al. A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia. 2021;619–29.
32. Bennett-Guerrero E, Romeiser JL, Talbot LR, Ahmed T, Mamone LJ, Singh SM, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial∗. Crit Care Med. 2021;1015–25.
33. Yoon H, Bartash R, Gendlina I, Rivera J, Nakouzi A, Bortz RH, et al. Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC. JCI Insight. 2021;6(4):1–14.
34. Yan M, Retna Indah S, Sefrina W, Made Ayu Lely S, Irmansyah. Uji Klinis Pemberian Plasma Konvalesen sebagai Terapi Tambahan Covid-19. Lap. KEMENKES RI Jakarta; 2020.
35. Transfusion Related Acute Lung Injury (TRALI) | FDA Tersedia : https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/transfusion-related-acute-lung-injury-trali, diakses tanggal 21 Desember 2022
36. Gharbharan A, Jordans CCE, Geurtsvankessel C, den Hollander JG, Karim F, Mollema FPN, et al. Convalescent Plasma for COVID-19. A randomized clinical trial. medRxiv. 2020;1–16.
37. WHO recommends against the use of convalescent plasma to treat COVID-19 Tersedia : https://www.who.int/news/item/07-12-2021-who-recommends-against-the-use-of-convalescent-plasma-to-treat-covid-19, diakses tanggal 22 Desember 2021
2. WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data. Tersedia : https://covid19.who.int/, diakses tanggal 6 Juni 2021
3. COVID-19 NTT Tersedia : http://covid19.nttprov.go.id/home, diakses tanggal 5 Juni 2021
4. Burhan E, Susanto AD, Nasution SA, Ginanjar E, Pitoyo CW, Susilo A, et al. PEDOMAN TATALAKSANA COVID-19 Edisi 3 TIM EDITOR Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi dan Terap. 2020. 88–89 p.
5. Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA - J Am Med Assoc. 2020;323(16):1582–9.
6. Li L, Zhang W, Hu Y, Tong X, Zheng S, Yang J, et al. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients with Severe and Life-threatening COVID-19: A Randomized Clinical Trial. JAMA - J Am Med Assoc. 2020 Aug 4;324(5):460–70.
7. Kementerian Kesehatan Republik Indonesia. Terapi Plasma Konvalesen, Harapan Baru Tangani COVID-19. Tersedia : https://www.kemkes.go.id/article/view/20090900001/terapi-plasma-konvalesen-harapan-baru-tangani-covid-19.html, diakses tanggal 15 Mei 2021
8. Sastroasmoro S, Ismael S. Dasar-dasar metode penelitian klinis. 2nd ed. Jakarta: CV Sagung Seto; 2002.
9. Ahn JY, Sohn Y, Lee SH, Cho Y, Hyun JH, Baek YJ, et al. Use of convalescent plasma therapy in two covid-19 patients with acute respiratory distress syndrome in Korea. J Korean Med Sci. 2020;35(14):2–9.
10. Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A. 2020;117(17):9490–6.
11. Ye M, Fu D, Ren Y, Wang F, Wang D, Zhang F, et al. Treatment with convalescent plasma for COVID ‐ 19 patients in Wuhan , China.
12. Mohammed H, Hama-ali HH, Nasraddin S, Muhammad K, Amin K, Othman S, et al. Severe refractory COVID-19 patients responding to convalescent plasma ; A case series. Ann Med Surg. Tersedia : https://doi.org/10.1016/j.amsu.2020.06.018
13. Huang S, Shen C, Xia C, Huang X, Fu Y, Tian L. A Retrospective Study on the Effects of Convalescent Plasma Therapy in 24 Patients Diagnosed with COVID-19 Pneumonia in February and March 2020 at 2 Centers in. 2020;1–9.
14. Joyner MJ, Marks P, Casadevall A, Joyner MJ, Wright RS, Fairweather D, et al. Early safety indicators of COVID-19 convalescent plasma in 5000 patients Early safety indicators of COVID-19 convalescent plasma in 5000 patients. 2020;130(9):4791–7.
15. Bar KJ, Siegel DL, Tebas P, Bar KJ, Shaw PA, Choi GH, et al. A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia. 2021;131(24):2–10.
16. Ibrahim D, Dulipsingh L, Zapatka L, Hussain, Eadie R, Crowell R, et al. Factors Associated with Good Patient Outcomes Following Convalescent Plasma in COVID-19 : A Prospective Phase II Clinical Trial. Infect Dis Ther. Tersedia : https://doi.org/10.1007/s40121-020-00341-2
17. Hu X, Hu C, Jiang D, Zuo Q, Li Y, Wang Y, et al. Effectiveness of Convalescent Plasma Therapy for COVID-19 Patients in. 2020;(December):1–12.
18. Gemİcİ A, Bİlgen H, Erdoğan C, Kansu A, Olmuşçelİk O. A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma. 2020;1781–5.
19. Allahyari A, Seddigh-Shamsi M, Mahmoudi M, Jamehdar SA, Amini M, Mozdourian M, et al. Efficacy and safety of convalescent plasma therapy in severe COVID-19 patients with acute respiratory distress syndrome. 2020;(January).
20. Avendaño-solá C, Duarte RF, Group C-S, Avendaño-solá C, Ramos-martínez A, Muñez-rubio E, et al. convalescent plasma in patients hospitalized with COVID-19 pneumonia A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumonia. 2021;131(20).
21. Avendaño-Solà C, Ramos-Martínez A, Muñez-Rubio E, Ruiz-Antorán B, Molina RM de, Torres F, et al. Convalescent Plasma for COVID-19 : A multicenter , randomized clinical trial Authors : Affiliations : 2020;
22. Li L, Tong X, Chen H, He R, Lv Q, Yang R, et al. Original research. 2020;1–8.
23. O’Donnell MR, Grinsztejn B, Cummings MJ, Justman JE, Lamb MR, Eckhardt CM, et al. A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. J Clin Invest. 2021;131(13):1–9.
24. Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T. Convalescent plasma in the management of moderate covid-19 in adults in India : open label phase II multicentre randomised controlled trial ( PLACID Trial ). :1–10.
25. Zhang B, Liu S, Tan T, Huang W, Dong Y, Chen L. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- research that is available on the COVID-19 resource centre - including this Treatment With Convalescent Plasma. 2020;(January).
26. Dai W, Wu J, Li T, Shen J, Pang R, Luo T, et al. Clinical outcomes for COVID ‐ 19 patients with diabetes mellitus treated with convalescent plasma transfusion in Wuhan , China.
27. Kurtz P, Righy C, Gadelha M, Bozza FA, Higa LM, Castilho L, et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19 : An Observational Study. 2021;8(January):1–9.
28. Rogers R, Shehadeh F, Mylona EK, Rich J, Neill M, Touzard-romo F, et al. Convalescent Plasma for Patients With Severe Coronavirus Disease 2019 ( COVID-19 ): A Matched Cohort Study. 2021;2019.
29. AlQahtani M, Abdulrahman A, Almadani A, Alali SY, Al Zamrooni AM, Hejab AH, et al. Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease. Sci Rep [Internet]. 2021;11(1):1–8. Tersedia : https://doi.org/10.1038/s41598-021-89444-5
30. Korley FK, Durkalski-Mauldin V, Yeatts SD, Schulman K, Davenport RD, Dumont LJ, et al. Early Convalescent Plasma for High-Risk Outpatients with Covid-19. N Engl J Med. 2021;385(21):1951–60.
31. Siminovich V, Pratx burgos L, Scibona P, Beruto M, Vallone M, Vazques C, et al. A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia. 2021;619–29.
32. Bennett-Guerrero E, Romeiser JL, Talbot LR, Ahmed T, Mamone LJ, Singh SM, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial∗. Crit Care Med. 2021;1015–25.
33. Yoon H, Bartash R, Gendlina I, Rivera J, Nakouzi A, Bortz RH, et al. Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC. JCI Insight. 2021;6(4):1–14.
34. Yan M, Retna Indah S, Sefrina W, Made Ayu Lely S, Irmansyah. Uji Klinis Pemberian Plasma Konvalesen sebagai Terapi Tambahan Covid-19. Lap. KEMENKES RI Jakarta; 2020.
35. Transfusion Related Acute Lung Injury (TRALI) | FDA Tersedia : https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/transfusion-related-acute-lung-injury-trali, diakses tanggal 21 Desember 2022
36. Gharbharan A, Jordans CCE, Geurtsvankessel C, den Hollander JG, Karim F, Mollema FPN, et al. Convalescent Plasma for COVID-19. A randomized clinical trial. medRxiv. 2020;1–16.
37. WHO recommends against the use of convalescent plasma to treat COVID-19 Tersedia : https://www.who.int/news/item/07-12-2021-who-recommends-against-the-use-of-convalescent-plasma-to-treat-covid-19, diakses tanggal 22 Desember 2021
Diterbitkan
2023-05-04
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Lokat, R., Riwu, M., Damanik, E. M., & Setianingrum, E. (2023). Efek Penggunaan Terapi Plasma Konvalesen pada Proses Pengobatan Pasien COVID-19. Cendana Medical Journal, 11(1), 149-159. https://doi.org/10.35508/cmj.v11i1.10722
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