EFFECT OF SAMBILOTO EXTRACT (Andrographis paniculata Nees ) ON HISTOPATHOLOGICAL DISCUSSION OF WHITE RATS (Rattus norvegicus) HIPERKOLESTEROLEMIA MODELS
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Lorenza Abatan(1*)
Universitas Nusa Cendana
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Derri Tallo Manafe(2)
2Departemen Fisiologi Fakultas Kedokteran dan Kedokteran Hewan Universitas Nusa Cendana
(*) Corresponding Author
Abstract
Introduction: Hypercholesterolemia is a state which can increase free radicals in the body. Sambiloto has antioxidant and anti-inflammation effects that will bind with the free radicals. Methods: This research is a laboratory experimental study with the approach of true experimental design post-test with control group applied to the treatment and control group. The sampling technique is using randomized probability sampling. Samples divided into 6 groups consisted of normal control group, negative control group, positive control group and 3 groups of applying the extract in several doses. Results: Bivariate analysis results shows there is a significant effect on sambiloto extract giving with the jejunum histopathological image on wistar strain white rats (Rattus norvegicus) exposed to hypercholesteremia model with the significance value of p= 0,001 (p<0,05). Discussion: Administration of Sambiloto extract at a dose of 800 mg/kgBB has a significant effect in repairing damage to the jejunum of white rats due to hypercholesterolemia. Sambiloto has antidislipidemia, antioxidant and anti-inflammatory effects. Andrographolid increases HDL levels by increasing the activity of lecithin cholesterol acyl transferase (LCAT). Conclusion: There is a significant result on sambiloto extract giving with the jejunum histopathological image on wistar strain white rats (Rattus norvegicus) exposed to hypercholesteremia model.
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