The “The Effect of Turmeric Extract Administration on the Histopathological Features of the Liver in DMBA-Induced White Rats.”
Pengaruh Pemberian Ekstrak Kunyit Terhadap Gambaran Histpatologi Hepar Tikus Putih Yang Diinduksi DMBA
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Agnes Yohalina(1)
Universitas Nusa Cendana
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Efrisca Damanik(2)
Universitas Nusa Cendana
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Sidarta Sagita(3)
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Agnes Yohalina(4*)
(*) Corresponding Author
Abstract
ABSTRACT
Background: Environmental contaminants and hazardous substances are the initiators that cause damage to human organs. DMBA found in motor vehicle pollutants, cigarettes, burning factory fumes can cause liver damage. The liver that is constantly exposed to toxic substances can be damaged. Turmeric with antioxidants and anti-inflammatory can prevent further damage.
Objective: To determine the effect of giving turmeric extract (Curcuma longa) on the liver histopathological picture of male Sprague Dawley rats induced 7,12 Dimethylbenzene α anthracene (DMBA).
Methods: This study used an experimental method with a post only control group design approach. The sample in this study consisted of 30 rats which were divided into 6 groups each consisting of 5 rats. The research data were tested with the Shapiro-Wilk normality test and continued with the non-parametric Kruskall Wallis test.
Results: The kruskall wallis test obtained p value = 0.011 (p> 0.05) indicating a significant difference between the test groups, followed by the Mann Whitney test which showed insignificant differences for the DMBA and turmeric extract groups on the histopathological picture of the liver. However, there was a decrease in the rate of liver damage after giving turmeric
Conclusion: There is a decrease in the average degree of liver damage induced by DMBA after giving turmeric extract but there is no significant difference.
Keywords: DMBA, Turmeric Extract, Liver Histopathology.
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References
Wardani RN, Sakinah EN, Nurdian Y. terhadap Kadar SGOT dan SGPT Tikus Wistar yang Diinduksi DMBA ( The Effect of Ethanolic Extract of Broccoli ( Brassica oleracea ) on SGOT and SGPT of Wistar Rats Induced by DMBA ).2016;4(2):196–9.
Endang Zainal Hasan A, Effend EM, Setiyono A, Sandi B. Kondisi Hati Tikus Betina Akibat Induksi 7,12-Dimethyl Benzalfa Antracene (DMBA) dan Penyembuhan dengan Propolis dan Nanopropolis Indonesia. Fitofarmaka J Ilm Farm.2014;
Ariani D, Muhartono, Mustofa S. Pengaruh pemberian ekstrak Phaleria macrocarpa terhadap gambaran histopatologis hepar tikus Sprague Dawley yang diinduksi 7,12-dymethylbenz(α)anthracene (DMBA). Med J Lampung Univ.2014;3(3):27–34.
Hakim L. Rempah & Herba Kebun-Pekarangan Rumah Masyarakat.2015.
Hartati SY. Khasiat Kunyit Sebagai Obat Tradisional Dan ManfaatLainnya.Vol. 19, Balitro. 2013. p. 5–9.
Badan Pusat Statistik. Statistik Tanaman Biofarnaka Indonesia.2015.
Judul H, Talan MD. Identifikasi Jamur Xerofilik pada Bubuk Kunyit( Curcuma domestica ) di Pasar Ttadisional Kabupaten Timor Tengah Selatan, Nusa Tenggara Timur.2019;
Yuan Shan C, Iskandar Y. Studi Kandungan Kimia Dan Aktivitas Farmakologi Tanaman Kunyit (Curcuma longa L.).Pharmacia.2018;16:547–55.
Universitas A. Profil Tampilan Fisik Dan Kandungan Kurkuminoid Dari Simplisia Temulawak (Curcuma Xanthorrhiza Roxb) Pada Beberapa Metode Pengeringan. J Sains Dan Mat. 2009;17(1):24–32.
Berlian Z, Pane ER, Hartati S, Biologi D, Biologi MP. Efektivitas Kunyit (Curcuma domestica) Sebagai Pereduksi Formalin Pada TahuNone. 2012;1(1):1–14.
Oratmangun sandriania alpius. Pengaruh Kombinasi Fraksi Etil Asetat Buah Pare (Momordica charantia L.) Dan Fraksi Etil Asetat Rimpang Kunyit (Curcuma domestica Val.); Terhadap Fungsi Hati Dan Ginjal Serta Gambaran Histopatologi Pada Tikus Resisten Insulin. Hilos Tensados. 2019;1:1–476.
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