BIOMARKER SEBAGAI UPAYA DIAGNOSIS MOLEKULER DAN IDENTIFIKASI DINI KANKER PROSTAT
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Imberd Rionard Liunima(1*)
Universitas Negeri Semarang
(*) Corresponding Author
Keywords:
Biomarker, Diagnosis, Molekuler, Prognosis, Kanker Prostat
Abstract
Biomarker memainkan peran penting dalam deteksi, diagnosis, dan prognosis kanker prostat. Biomarker ini dapat digunakan untuk mengidentifikasi biomarker spesifik dalam sampel biologis, mendiagnosis kanker, dan memprediksi hasil pengobatan. Tujuan dari artikel ini untuk membahas biomarker sebagai upaya deteksi dini, diagnosis, dan prognosis kanker prostat, Penelitian ini menggunakan metode tinjauan literatur, memanfaatkan sumber dari jurnal akademik di antaranya: PubMed (n:23), MPDI (n:56) dan Elsevier (n:8) tahun 2010-2024.
Beberapa biomarker telah diidentifikasi untuk deteksi dini diagnosis, kanker prostat, antara lain: DNA, RNA, perubahan epigenetik, protein, metabolit, sel, lamin, galektin, antigen karbohidrat, virus, dan lipid. Biomarker ini dapat digunakan untuk mengidentifikasi biomarker spesifik dalam sampel biologis, mendiagnosis kanker prostat, dan memprediksi hasil pengobatan. Penelitian lebih lanjut diperlukan untuk mengembangkan biomarker yang lebih efektif dan meningkatkan diagnosis dan pengobatan kanker prostat.
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References
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Kamińska, Katarzyna, Ewelina Nalejska, Marta Kubiak, Joanna Wojtysiak, Łukasz Żołna, Janusz Kowalewski, and Marzena Anna Lewandowska. 2019. “Prognostic and Predictive Epigenetic Biomarkers in Oncology.” Molecular Diagnosis and Therapy 23(1):83–95. doi: 10.1007/s40291-018-0371-7.
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Mbeje, Mandisa, Jeyalakshmi Kandhavelu, Clement Penny, Mmamoletla Kgoebane-Maseko, Zodwa Dlamini, and Rahaba Marima. 2023. “In Silico Bioinformatics Analysis on the Role of Long Non-Coding RNAs as Drivers and Gatekeepers of Androgen-Independent Prostate Cancer Using LNCaP and PC-3 Cells.” Current Issues in Molecular Biology 45(9):7257–74. doi: 10.3390/cimb45090459.
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Passaro, Antonio, Maise Al Bakir, Emily G. Hamilton, Maximilian Diehn, Fabrice André, Sinchita Roy-Chowdhuri, Giannis Mountzios, Ignacio I. Wistuba, Charles Swanton, and Solange Peters. 2024. “Cancer Biomarkers: Emerging Trends and Clinical Implications for Personalized Treatment.” Cell 187(7):1617–35. doi: 10.1016/j.cell.2024.02.041.
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