Sintesis Turunan Diarilpentanoid dari Sinamaldehida
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Reinner Ishaq Lerrick(1*)
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Karolina T. Sanit(2)
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Imanuel Gauru(3)
(*) Corresponding Author
Keywords:
Cinnamaldehyde, Diphenylpentanoid, Aldol condensation
Abstract
Synthesis of 1,5-Diphenylpenta-2,4-dien-1-one from local cinnamaldehyde has been done. Through aldol condensation reaction submission of local cinnamaldehyde with acetophenone in the presence of KOH resulted in 57% yellow oil confirmed as the desired product by GMMS analysis.
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References
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2. Syam, S., Abdelwahab, S. I., Al-Mamary, M. A., and Mohan, S. 2012. Synthesis Of Chalcones with Anticancer Activities. Molecules. 17 : 6179-6195.
3. S. M. Mohd Faudzi,, S. W. Leong, F. Abas, M. F. F. Mohd Aluwi, K. Rullah, K..W. Lam, S. Ahmad, C. L. Tham, K. Shaari, and N. H. Lajis., Med. Chem. Commun., 2015,6, 1069-1080.
4. Kashyap, S.J., Garg, V.K., Dudhe, R., Sharma, P. K., dan Kumar, N. 2011. Synthesis and In-Vitro Antioxidant Activity of Subtituted Chalcone Derivatives. International Journal of Drug Formulation and Research. 4 (2) : 324-336.
5. Doan, T. N., dan Tran, D. T. 2011. Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones. Scientific Research. 2 : 282-288.
6. Kamble, V. M., Hatnapure, G. D., Keche, A. P., Biradjar, S., Patil, S.G., Tale, R. H., Rodge, A. H., Turkar, S.S., & Gour, K. 2011. Synthesis and Biological Evaluation Of a Novel Series of Metoxylated Chalcone as Antioxidant and Anti-microbial Agents. Journal of Chemical and Pharmaceutical Research Research. 3 (6) : 639-648.
7. Tiwari, B., Pratapwar, A. S., Tapas, A. R., Butle, S. R., and Vatkar, B. S. 2010. Synthesis and Antimirobial Activity of Some Chalcone Derivatives. International Journal of ChemTech Research. 2 (1) : 499-503.
8. Rao, Y.K., Fang, S., Tzeng, Y. 2004. Differential Effects of Synthesized 2’-oxygenate Chalcone Derivatives: Modulation of Human Cell Cycle Phase Distribution. Bioorganic and Medicinal Chemistry.12(10): 2679-2686.
9. Azizah, Y., Hanapi, A., dan Adi, T. K. 2015. Synthesis Of 3-(4-Hydroxy-3 Metoxyphenil)-1-Phenyl-2-Propen-1-On and its Antioxidant Activity Assay Using DPPH. Jurnal ALCHEMY. 4 (1) : 67-72.
Published
2022-06-22
How to Cite
Lerrick, R., Sanit, K., & Gauru, I. (2022). Sintesis Turunan Diarilpentanoid dari Sinamaldehida. Chemistry Notes, 4((1), 20-30. https://doi.org/10.35508/cn.v4i(1).8134
Section
Articles
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