Bioaktivitas Metabolit Sekunder dari Genus Dipterocarpus
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Halena A. Nalle(1)
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Theodore Y. K. Lulan(2*)
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Philiphi de Rozari(3)
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Antonius R. B. Ola(4)
(*) Corresponding Author
Keywords:
Chemical compounds, Biological activities, Dipterocarpus
Abstract
Research has been conducted with the title "Literature Study of Secondary Metabolites and Bioactivity of Plants Genus Dipterocarpus". The method used is a descriptive method with the aim of being to find out the active compounds in the genus plant dipterocarpus and to know the ability of the bioactivity of genus plants dipterocarpus. Based on the results of the study, bioactivity of secondary metabolites from planst of the genus dipterocarpus namely antidiabetic, antiplasmodial, antibacterial, antioxidant, anticlasses, cytotoxic, anticholinesterase, antiproliferation, anti-inflammatory and antimicrobial. Very strong biosaltivity indicated by the ethyl acetate faction plant D. Intricatus Sagai Antioxidant IC50 Nialial is 0.075 μg / mL. While very weak bioacchables are shown extract methanol stem plant D. Costatus as cytotoxic with ic50 value 973 ± 14.57 μg / mL.
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References
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19. Surapinit, Serm., Jonkolnee Jong-Aramruang, Pongpun Siripong, Suttira Khumkratok Dan Santi Tip-Pyang. 2014. Dipterostilbenosides A And B, Oligostilbene Glycosides From Dipterocarpus Tuberculatus. Natural Product Communications, Vol. 9, Hal. 1323-1326.
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21. Salleh, Wan Mohd Nuzul Hakimi Wan., Shamsul Khamis, Muhammad Nurakmal Abdul Rahman Dan Mohd Azlan Nafiah. 2020. Chemical Composition And Biological Activities Of Dipterocarpus Cornatus Dyer Essential Oil. Zeitschrift Fur Naturforschung - Section C Journal Of Biosciences, Vol. 75, Hal. 171-175.
22. Chen, Chao Jun., Rong Jiang, Gang Wang, Rui Hua Jiao, Chompoonuch Tancharoen, Kanokorn Sudto, Sranya Vajarothai, Supa Hannongbua, Hui Ming Ge Dan Ren Xiang Tan. 2014. Oligostilbenoids With Acetylcholinesterase Inhibitory Activity From Dipterocarpus Alatus. Planta Medica, Vol. 80, Hal. 1641-1646.
23. Yang, Woo Seok., Byoung-Hee Lee, Shi Hyoung Kim, Han Gyung Kim, Young-Su Yi, Khin Myo Htwe, Young-Dong Kim, Ki Dong Yoon, Sungyoul Hong, Woo-Shin Lee Dan Jae Youl Cho. 2013. Dipterocarpus Tuberculatus Ethanol Extract Strongly Suppresses In Vitro Macrophage-Mediated Inflamatory Responses And In Vivo Acute Gastritis. Journal Of Ethnopharmacological, Vol. 146, Hal. 873-880.
24. Sutjaritvorakul, T., Whalley, A. J. S., Sihanonth, P Dan Roengsumran, S. 2011. Antimicrobial Activity From Endophytic Fungi Isolated From Plant Leaves In Dipterocarpus Forest An Viengsa District Nan Province, Thailand. Journal Of Agricultural Tecnology, Vol. 7, Hal. 115-121.
2. Alrasyid H, Marfuah, Wijaya Kusuma dan Hendarsyah. 1991. Vamedicum Dipterocarpaceae. Balai Penelitian dan Pengembangan Hutan, Departemen Kehutanan, Jakarta.
3. Lulan, Theodore Y. K., Sri Fatmawati, Mardi Santoso Dan Taslim Ersam. 2020. Α-Viniferin As A Potential Antidiabetic And Antiplasmodial Extracted From Dipterocarpus Littoralis. Heliyon, Vol. 6.
4. Smirnova, Iriana E. Anastasiya V. Petrova, Oxana B. Kazakova, El’za M. Minnibaeva, Alexandra A. Fedorova, Loc Tran Van, Chien Tran Van, Ninh Pham Thi, Thao Tran Thi Phuong, Dong Nguyen Thi And Ha Thi Thu Nguyen. 2019. Synthesis Of Dammarenolic Acid Derivatives With A Potent Α-Glucosidase Inhibitory Activity. Medicinal Chemistry Research.
5. Le, Hong Thia., Thao Nguyen Luu, Huynh Mah Thu Nguyen, Dang Hoai Trang Nguyen, Pham Tan Quoc Le, Ngoc Nam Trinh, Van Son Le, Hoang Dung Nguyen Dan Hong Thien Van. 2021. Antibakcterial, Antioxidant And Cytotoxic Activities Of Different Fractions Of Acetone Extract From Flowers Of Dipterocarpus Intricatus Dyer (Dipterocarpaceae).Plant Science Today, Vol. 8(2), Hal. 273-277.
6. Aziz, Abdul. 2015. Karakteristik Populasi Dan Potensi Bioprospeksi Keruing Gunung (Dipterocarpus Retusus Bl.) Di Taman Nasional Gunung Rinjani, Provinsi NTB. Sekolah Pascasarjana Institut Pertanian Bogor.
7. Zain, Wan Zuraida Wan Mohd., Norizan Ahmad, Nor Hazana Norizan Dan Nur Ainaa Atikah Mohd Nazri. 2011. The Evaluation Of Antioxidant, Antibacterial And Structural Identification Activity Of Trimer Resveratrol From Malaysia’s Dipterocarpaceae. Australian Journal Of Basic And Apploed Science, Vol. 5, Hal. 926-929.
8. Samad, Shamaa Abdul Dan W. Sadin De Silva. 2021. Phytochemical Analysis And Antibacterial Efficacy Of Extracts Of Dipterocarpus Zeylanicus. International Journal Of Health And Life-Sciences, Vol. 6, No. 3, Hal. 35-53.
9. Zain, Wan Zuraida Wan Mohd., Notizan Ahmat Dan Che Puteh Osman. 2018. Antioxidant Activities Of Oligostilbenoids The Stem Bark Of Dipterocarpus Verrucosus, Dipterocarpus Crinitus And Dipterocarpus Cornatus. International Journal Of Engineering And Technology, Vol. 7, Hal. 409-414.
10. Yongram, Chawalit., Bunleu Sungthong, Pleonthip Puthongking Dan Natthida Weerapreeyakul. 2019. Chemical Composition, Antioxidant And Cytotoxicity Activities Of Leaves Bark, Twigs And Oleo-Resin Of Dipterocarpus Alatus. Molecules, Vol 24.
11. Biswas, Diptanu., T. Shivraj Douda Dan Narayanswamy Lachmanan Gowrishankar. 2016. Hepatoprotective And Antioxidant Activity Of Ethanol Extract Of Dipterocarpus Turbinatus (Dipterocarpaceae) From Tripura. Journal Of Natural Remedies, Vol. 16, Hal. 100-107.
12. Senathilake, K.S., E. H. Karunanayake, S. R. Samarakoon, K. H. Tennekoon, E. D. De Silva, Dan A. Adhikari. 2017. Oleonolic Acid From Antifilaria Triterpene Saponins Of Dipterocarpus Zeylanicus Induces Oxidative Stress And Apoptosis In Filarial Parasite Setaria Digitata In Vitro. Journal Experimental Parasitology, Vol. 177, Hal. 13-21.
13. Muhtadi, Euis H. Hakim, Yana M. Syah, Lia D. Juliawaty, Sjamsul A. Achmad Dan Jalifah Latip. 2001. Lima Senyawa Fenolik Dari Kulit Batang Dipterocarpus Elongates (Dipterocarpaceae) Dan Sifat Sitotoksiknya Terhadap Sel Murin Leukimia P-388.
14. Muhtadi, Euis H. Hakim, Lia D. Juliawaty, Yana M. Syah, Sjamsul A. Achmad, Jalifah Latip Dan Emilio L. Ghisalberti. 2006. Cytotoxic Resveratrol Oligomers From The Tree Bark Of Dipterocarpus Hasseltii. Fitoterapi, Vol. 77, Hal. 550-555.
15. Muhtadi, Euis H. Hakim, Yana M. Syah, Lia D. Juliawaty, Laily bin Din dan Jalifah Latip. 2007. Resveratrol Oligome Compounds from The Tree Bark Of Dipterocarpus Retusus Blume and Cytotoxic Effect Against Murine Leukaemia P388. Pharmacon, Vol. 8, Hal. 6-12.
16. Muhtadi, Dkk. 2008. Pemisahan Senyawa- Senyawa Yang Bersifat Sitotoksik Terhadap Sel Murin Leukimia P388 Dari Ekstrak Metanol Kulit Batang Dipterocarpus Confertus Sloot (Dipterocarpus).
17. Ashton, P.S. 1983. Dipterocarpaceae. In C.G.G.J. Van Steenis [ed.], Flora Malesiana, Series 1, Spermatophyta. Martinus Nijhoff Publisers,The Hague, Vol. 9, 391-436.
18. Khiev, Piseth., Ok-Kyoung Kwon, Hyuk-Hwan Song, Sei-Ryang Oh, Kyung-Seop Ahn, Hyeong-Kyu Lee Dan Young-Won Chin. 2012. Cytotoxic Terpenes From The Stems Of Dipterocarpus Obtusifolius Collected In Combadia. Chemical And Pharmaceutical Bulletin, Vol. 60, Hal. 955-961.
19. Surapinit, Serm., Jonkolnee Jong-Aramruang, Pongpun Siripong, Suttira Khumkratok Dan Santi Tip-Pyang. 2014. Dipterostilbenosides A And B, Oligostilbene Glycosides From Dipterocarpus Tuberculatus. Natural Product Communications, Vol. 9, Hal. 1323-1326.
20. Nguyen, Sinh Troung. Nghia Minh Do, Phuc Hong Vo, Mai Thi Thanh Nguyen, Nhan Trung Nguyen, Hai Xuan Nguyen, Kiet Dinh Truong, And Phuc Van Pham. 2020. Selective Cytotoxicity Of Some Plant Extracts Against Hepatocellular Carcinoma Cells But Not Mesenchymal Stem Cells: A Pilot Screening. Medicine Biology.
21. Salleh, Wan Mohd Nuzul Hakimi Wan., Shamsul Khamis, Muhammad Nurakmal Abdul Rahman Dan Mohd Azlan Nafiah. 2020. Chemical Composition And Biological Activities Of Dipterocarpus Cornatus Dyer Essential Oil. Zeitschrift Fur Naturforschung - Section C Journal Of Biosciences, Vol. 75, Hal. 171-175.
22. Chen, Chao Jun., Rong Jiang, Gang Wang, Rui Hua Jiao, Chompoonuch Tancharoen, Kanokorn Sudto, Sranya Vajarothai, Supa Hannongbua, Hui Ming Ge Dan Ren Xiang Tan. 2014. Oligostilbenoids With Acetylcholinesterase Inhibitory Activity From Dipterocarpus Alatus. Planta Medica, Vol. 80, Hal. 1641-1646.
23. Yang, Woo Seok., Byoung-Hee Lee, Shi Hyoung Kim, Han Gyung Kim, Young-Su Yi, Khin Myo Htwe, Young-Dong Kim, Ki Dong Yoon, Sungyoul Hong, Woo-Shin Lee Dan Jae Youl Cho. 2013. Dipterocarpus Tuberculatus Ethanol Extract Strongly Suppresses In Vitro Macrophage-Mediated Inflamatory Responses And In Vivo Acute Gastritis. Journal Of Ethnopharmacological, Vol. 146, Hal. 873-880.
24. Sutjaritvorakul, T., Whalley, A. J. S., Sihanonth, P Dan Roengsumran, S. 2011. Antimicrobial Activity From Endophytic Fungi Isolated From Plant Leaves In Dipterocarpus Forest An Viengsa District Nan Province, Thailand. Journal Of Agricultural Tecnology, Vol. 7, Hal. 115-121.
Published
2021-12-19
How to Cite
Nalle, H., Lulan, T. Y., de Rozari, P., & Ola, A. R. (2021). Bioaktivitas Metabolit Sekunder dari Genus Dipterocarpus. Chemistry Notes, 3(2), 1-11. https://doi.org/10.35508/cn.v3i2.6078
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